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Stx11 syntaxin 11 [ Mus musculus (house mouse) ]

Gene ID: 74732, updated on 2-Nov-2024

Summary

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Official Symbol
Stx11provided by MGI
Official Full Name
syntaxin 11provided by MGI
Primary source
MGI:MGI:1921982
See related
Ensembl:ENSMUSG00000039232 AllianceGenome:MGI:1921982
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5830405C08Rik
Summary
Predicted to enable SNAP receptor activity and SNARE binding activity. Acts upstream of or within cellular response to type II interferon and leukocyte degranulation. Located in phagocytic vesicle. Is expressed in appendicular skeleton; brain; heart; and pancreas. Used to study familial hemophagocytic lymphohistiocytosis 4. Human ortholog(s) of this gene implicated in familial hemophagocytic lymphohistiocytosis 4. Orthologous to human STX11 (syntaxin 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in spleen adult (RPKM 7.1), lung adult (RPKM 6.6) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Stx11 in Genome Data Viewer
Location:
10 A2; 10 4.54 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (12813961..12840242, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (12938217..12964498, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene utrophin Neighboring gene cofilin-1 pseudogene Neighboring gene RIKEN cDNA B230208H11 gene Neighboring gene STARR-seq mESC enhancer starr_25804 Neighboring gene STARR-positive B cell enhancer ABC_E2928 Neighboring gene nuclear encoded tRNA leucine 3 (anticodon TAA) Neighboring gene STARR-positive B cell enhancer mm9_chr10:12683331-12683631 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:12684154-12684263 Neighboring gene STARR-positive B cell enhancer mm9_chr10:12716948-12717249 Neighboring gene STARR-positive B cell enhancer ABC_E5119 Neighboring gene predicted gene, 57557 Neighboring gene splicing factor 3b, subunit 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Dynamic palmitoylation of STX11 controls injury-induced fatty acid uptake to promote muscle regeneration. Wang J, et al. Dev Cell, 2024 Feb 5. PMID 38198890
  2. A novel immunoregulatory role for NK-cell cytotoxicity in protection from HLH-like immunopathology in mice. Sepulveda FE, et al. Blood, 2015 Feb 26. PMID 25525117
  3. Syntaxin 11 is required for NK and CD8⁺ T-cell cytotoxicity and neutrophil degranulation. D'Orlando O, et al. Eur J Immunol, 2013 Jan. PMID 23042080, Free PMC Article
  4. Syntaxin 11 binds Vti1b and regulates late endosome to lysosome fusion in macrophages. Offenhäuser C, et al. Traffic, 2011 Jun. PMID 21388490
  5. Syntaxin 11 regulates the stimulus-dependent transport of Toll-like receptor 4 to the plasma membrane by cooperating with SNAP-23 in macrophages. Kinoshita D, et al. Mol Biol Cell, 2019 Apr 15. PMID 30811271, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Patients and mice with deficiency in the SNARE protein SYNTAXIN-11 have a secondary B cell defect.
    Title: Patients and mice with deficiency in the SNARE protein SYNTAXIN-11 have a secondary B cell defect.
  2. Dynamic palmitoylation of STX11 controls injury-induced fatty acid uptake to promote muscle regeneration.
    Title: Dynamic palmitoylation of STX11 controls injury-induced fatty acid uptake to promote muscle regeneration.
  3. Findings suggest that stx11 regulates the stimulus-dependent transport of TLR4 to the plasma membrane by cooperating with SNAP-23 in macrophages. Our results clarify the regulatory mechanisms underlying intracellular transport of TLR4 and have implications for microbial pathogenesis and immune responses.
    Title: Syntaxin 11 regulates the stimulus-dependent transport of Toll-like receptor 4 to the plasma membrane by cooperating with SNAP-23 in macrophages.
  4. required for NK and CD8+ T cell cytotoxicity and neutrophil degranulation
    Title: Syntaxin 11 is required for NK and CD8⁺ T-cell cytotoxicity and neutrophil degranulation.
  5. Distinct severity of HLH in both human and murine mutants with complete loss of cytotoxic effector PRF1, RAB27A, and STX11.
    Title: Distinct severity of HLH in both human and murine mutants with complete loss of cytotoxic effector PRF1, RAB27A, and STX11.
  6. Blockade of inhibitory receptors on T cells in Stx11-deficient mice converted nonfatal disease course into fatal HLH, identifying T-cell exhaustion as an important factor for determination of disease severity in hemophagocytic lymphohistiocytosis.
    Title: Hemophagocytic lymphohistiocytosis in syntaxin-11-deficient mice: T-cell exhaustion limits fatal disease.
  7. Results suggest that by regulating the availability of Vti1b, Stx11 regulates trafficking steps between late endosomes, lysosomes and the cell surface in macrophages.
    Title: Syntaxin 11 binds Vti1b and regulates late endosome to lysosome fusion in macrophages.
  8. Stx11 were highly expressed at the end of fetal development but downregulated at 4 and 11 weeks in brain, pancreas, and heart.
    Title: Developmental methylation program and concerted expression of Stx11 in mouse tissues.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (3)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNAP receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within T cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cellular response to type II interferon IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cytotoxic T cell degranulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in membrane fusion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within natural killer cell degranulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within natural killer cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neutrophil degranulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle fusion to presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in phagocytic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
syntaxin-11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163590.1 → NP_001157062.1  syntaxin-11

    See identical proteins and their annotated locations for NP_001157062.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AL691505
    Consensus CDS
    CCDS48500.1
    UniProtKB/Swiss-Prot
    Q9D3G5
    UniProtKB/TrEMBL
    Q3TAS3, Q3U5V8
    Related
    ENSMUSP00000132758.2, ENSMUST00000163425.9
    Conserved Domains (2) summary
    pfam00804
    Location:41 → 238
    Syntaxin
    cl22856
    Location:207 → 273
    SNARE; SNARE motif

  2. NM_001163591.1 → NP_001157063.1  syntaxin-11

    See identical proteins and their annotated locations for NP_001157063.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AL691505
    Consensus CDS
    CCDS48500.1
    UniProtKB/Swiss-Prot
    Q9D3G5
    UniProtKB/TrEMBL
    Q3TAS3, Q3U5V8
    Conserved Domains (2) summary
    pfam00804
    Location:41 → 238
    Syntaxin
    cl22856
    Location:207 → 273
    SNARE; SNARE motif

  3. NM_029075.1 → NP_083351.1  syntaxin-11

    See identical proteins and their annotated locations for NP_083351.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK017897, AK153408, BY753247
    Consensus CDS
    CCDS48500.1
    UniProtKB/Swiss-Prot
    Q9D3G5
    UniProtKB/TrEMBL
    Q3TAS3, Q3U5V8
    Related
    ENSMUSP00000046243.6, ENSMUST00000042861.7
    Conserved Domains (2) summary
    pfam00804
    Location:41 → 238
    Syntaxin
    cl22856
    Location:207 → 273
    SNARE; SNARE motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    12813961..12840242 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512886.4 → XP_006512949.1  syntaxin-11 isoform X1

    See identical proteins and their annotated locations for XP_006512949.1

    UniProtKB/Swiss-Prot
    Q9D3G5
    UniProtKB/TrEMBL
    Q3TAS3, Q3U5V8
    Conserved Domains (2) summary
    pfam00804
    Location:41 → 238
    Syntaxin
    cl22856
    Location:207 → 273
    SNARE; SNARE motif

  2. XM_006512887.4 → XP_006512950.1  syntaxin-11 isoform X1

    See identical proteins and their annotated locations for XP_006512950.1

    UniProtKB/Swiss-Prot
    Q9D3G5
    UniProtKB/TrEMBL
    Q3TAS3, Q3U5V8
    Conserved Domains (2) summary
    pfam00804
    Location:41 → 238
    Syntaxin
    cl22856
    Location:207 → 273
    SNARE; SNARE motif

  3. XM_006512888.5 → XP_006512951.1  syntaxin-11 isoform X1

    See identical proteins and their annotated locations for XP_006512951.1

    UniProtKB/Swiss-Prot
    Q9D3G5
    UniProtKB/TrEMBL
    Q3TAS3, Q3U5V8
    Conserved Domains (2) summary
    pfam00804
    Location:41 → 238
    Syntaxin
    cl22856
    Location:207 → 273
    SNARE; SNARE motif
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D3G5.1 GenPept UniProtKB/Swiss-Prot:Q9D3G5

Gene LinkOut

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