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Spata17 spermatogenesis associated 17 [ Mus musculus (house mouse) ]

Gene ID: 74717, updated on 28-Oct-2024

Summary

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Official Symbol
Spata17provided by MGI
Official Full Name
spermatogenesis associated 17provided by MGI
Primary source
MGI:MGI:1921967
See related
Ensembl:ENSMUSG00000026611 AllianceGenome:MGI:1921967
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MSRG-11; 1700065F16Rik; 4930504I07Rik; 4930513F16Rik
Summary
Predicted to enable calmodulin binding activity. Predicted to be involved in establishment of meiotic spindle localization; mitotic cell cycle; and spindle organization. Predicted to be located in cytoplasm. Predicted to be active in spindle pole. Orthologous to human SPATA17 (spermatogenesis associated 17). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in testis adult (RPKM 7.8) and lung adult (RPKM 0.3) See more
Orthologs
human all
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Genomic context

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See Spata17 in Genome Data Viewer
Location:
1 H5; 1 90.23 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (186741811..186947705, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (187009614..187215511, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03363 Neighboring gene DNA segment, Chr 1, Pasteur Institute 1 Neighboring gene proteasome (prosome, macropain) subunit, beta type 4 pseudogene Neighboring gene RIKEN cDNA 1700007P06 gene Neighboring gene STARR-seq mESC enhancer starr_03364 Neighboring gene predicted gene 15509 Neighboring gene STARR-seq mESC enhancer starr_03365 Neighboring gene STARR-positive B cell enhancer ABC_E2596 Neighboring gene G patch domain containing 2 Neighboring gene predicted gene, 51737 Neighboring gene STARR-positive B cell enhancer mm9_chr1:189146346-189146647 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:189172430-189172617 Neighboring gene STARR-seq mESC enhancer starr_03368 Neighboring gene STARR-positive B cell enhancer ABC_E8782 Neighboring gene predicted gene, 37896

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular cloning of MSRG-11 gene related to apoptosis of mouse spermatogenic cells. Deng Y, et al. Acta Biochim Biophys Sin (Shanghai), 2005 Mar. PMID 15756417
  2. Expression and identification of a novel apoptosis gene Spata17 (MSRG-11) in mouse spermatogenic cells. Deng Y, et al. Acta Biochim Biophys Sin (Shanghai), 2006 Jan. PMID 16395525
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Flow cytometry analysis showed that the expression of Spata17 protein in the GC-1 cell line could accelerate GC-1 cell apoptosis [Spata17]
    Title: Expression and identification of a novel apoptosis gene Spata17 (MSRG-11) in mouse spermatogenic cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC107213

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in establishment of meiotic spindle localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
spermatogenesis-associated protein 17
Names
spermatogenesis-related protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028848.3 → NP_083124.1  spermatogenesis-associated protein 17 isoform 1

    See identical proteins and their annotated locations for NP_083124.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK015780
    Consensus CDS
    CCDS15604.1
    UniProtKB/Swiss-Prot
    Q5FWA7, Q8BQE6, Q9D552
    Related
    ENSMUSP00000027908.7, ENSMUST00000027908.13

  2. NM_029067.1 → NP_083343.1  spermatogenesis-associated protein 17 isoform 2

    See identical proteins and their annotated locations for NP_083343.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a distinct 3' coding region and UTR and lacks multiple 3' exons, compared to variant 1. The encoded protein (isoform 2) has a shorter, distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK050925, BC089520
    Consensus CDS
    CCDS48479.1
    UniProtKB/Swiss-Prot
    Q9D552
    Related
    ENSMUSP00000106570.2, ENSMUST00000110945.4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    186741811..186947705 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497207.4 → XP_006497270.1  spermatogenesis-associated protein 17 isoform X1

    See identical proteins and their annotated locations for XP_006497270.1

    UniProtKB/Swiss-Prot
    Q5FWA7, Q8BQE6, Q9D552

  2. XM_036154032.1 → XP_036009925.1  spermatogenesis-associated protein 17 isoform X1

    UniProtKB/Swiss-Prot
    Q5FWA7, Q8BQE6, Q9D552

  3. XM_036154027.1 → XP_036009920.1  spermatogenesis-associated protein 17 isoform X1

    UniProtKB/Swiss-Prot
    Q5FWA7, Q8BQE6, Q9D552

  4. XM_036154036.1 → XP_036009929.1  spermatogenesis-associated protein 17 isoform X2

  5. XM_030243227.1 → XP_030099087.1  spermatogenesis-associated protein 17 isoform X3

    Conserved Domains (1) summary
    COG5022
    Location:102 → 185
    COG5022; Myosin heavy chain [General function prediction only]

  6. XM_006497210.3 → XP_006497273.1  spermatogenesis-associated protein 17 isoform X4

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D552.1 GenPept UniProtKB/Swiss-Prot:Q9D552

Gene LinkOut

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