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Cd200r3 CD200 receptor 3 [ Mus musculus (house mouse) ]

Gene ID: 74603, updated on 2-Nov-2024

Summary

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Official Symbol
Cd200r3provided by MGI
Official Full Name
CD200 receptor 3provided by MGI
Primary source
MGI:MGI:1921853
See related
Ensembl:ENSMUSG00000036172 AllianceGenome:MGI:1921853
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mCD200RLb; 4733401I18Rik; 4833409J19Rik
Summary
Enables signaling receptor activity. Predicted to be involved in regulation of neuroinflammatory response. Located in external side of plasma membrane. Orthologous to several human genes including CD200R1 (CD200 receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in bladder adult (RPKM 2.4) and liver E14.5 (RPKM 0.1) See more
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Genomic context

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See Cd200r3 in Genome Data Viewer
Location:
16 B4- B5; 16 29.25 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (44763959..44878728)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (44943596..45058365)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene lactate dehydrogenase A pseudogene Neighboring gene Cd200 receptor 2 Neighboring gene predicted gene, 53957 Neighboring gene Cd200 receptor 2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7453 Neighboring gene STARR-seq mESC enhancer starr_40912 Neighboring gene predicted gene, 53958 Neighboring gene coiled-coil domain containing 80

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CD200 is a novel p53-target gene involved in apoptosis-associated immune tolerance. Rosenblum MD, et al. Blood, 2004 Apr 1. PMID 14644999
  2. Mast cells and basophils are selectively activated in vitro and in vivo through CD200R3 in an IgE-independent manner. Kojima T, et al. J Immunol, 2007 Nov 15. PMID 17982101
  3. Recombinant CD200 protein does not bind activating proteins closely related to CD200 receptor. Hatherley D, et al. J Immunol, 2005 Aug 15. PMID 16081818
  4. CD200 receptor family members represent novel DAP12-associated activating receptors on basophils and mast cells. Voehringer D, et al. J Biol Chem, 2004 Dec 24. PMID 15471863
  5. CD200 is a ligand for all members of the CD200R family of immunoregulatory molecules. Gorczynski R, et al. J Immunol, 2004 Jun 15. PMID 15187158

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CD200R3 functions as an activating receptor on mast cells and basophils to regulate IgE-independent immune responses in cooperation with an inhibitory receptor CD200R
    Title: Mast cells and basophils are selectively activated in vitro and in vivo through CD200R3 in an IgE-independent manner.
  2. Expression of the immunoregulatory protein CD200 increases as murine dendritic cells undergo apoptosis.
    Title: CD200 is a novel p53-target gene involved in apoptosis-associated immune tolerance.
  3. during parasitic helminth infection, we identified CD200 receptor-like 3 as a transcript highly expressed in basophils and mast cells
    Title: CD200 receptor family members represent novel DAP12-associated activating receptors on basophils and mast cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC123954

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of neuroinflammatory response IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cell surface glycoprotein CD200 receptor 3
Names
CD200 cell surface glycoprotein receptor 3
CD200 cell surface glycoprotein receptor-like 3
CD200 cell surface glycoprotein receptor-like b
CD200 receptor-like 3
CD200RLb
cell surface glycoprotein OX2 receptor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128132.1 → NP_001121604.1  cell surface glycoprotein CD200 receptor 3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001121604.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC124600
    Consensus CDS
    CCDS49856.1
    UniProtKB/TrEMBL
    E9Q7T2
    Related
    ENSMUSP00000110258.4, ENSMUST00000114611.10

  2. NM_001128133.1 → NP_001121605.1  cell surface glycoprotein CD200 receptor 3 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001121605.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
    Source sequence(s)
    AC124600, AK014671
    Consensus CDS
    CCDS49858.1
    UniProtKB/Swiss-Prot
    Q5UKY4
    Related
    ENSMUSP00000110269.4, ENSMUST00000114622.10

  3. NM_027578.1 → NP_081854.1  cell surface glycoprotein CD200 receptor 3 isoform 4 precursor

    See identical proteins and their annotated locations for NP_081854.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences in the coding region and 3' UTR, compared to variant 1. It encodes isoform 4 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC124600
    Consensus CDS
    CCDS49859.1
    UniProtKB/Swiss-Prot
    Q5UKY4
    Related
    ENSMUSP00000132938.2, ENSMUST00000171779.8

  4. NM_029018.4 → NP_083294.2  cell surface glycoprotein CD200 receptor 3 isoform 3 precursor

    See identical proteins and their annotated locations for NP_083294.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses a different 3' terminal exon, compared to variant 1. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC124600, AK040868, AY230199
    Consensus CDS
    CCDS49857.1
    UniProtKB/TrEMBL
    E9Q7T2
    Related
    ENSMUSP00000130480.2, ENSMUST00000164007.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    44763959..44878728
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246035.1 → XP_011244337.1  cell surface glycoprotein CD200 receptor 3 isoform X7

  2. XM_011246032.2 → XP_011244334.1  cell surface glycoprotein CD200 receptor 3 isoform X3

  3. XM_011246030.3 → XP_011244332.1  cell surface glycoprotein CD200 receptor 3 isoform X1

  4. XM_011246031.4 → XP_011244333.1  cell surface glycoprotein CD200 receptor 3 isoform X2

  5. XM_017317153.2 → XP_017172642.1  cell surface glycoprotein CD200 receptor 3 isoform X4

    UniProtKB/TrEMBL
    E9Q7T2

  6. XM_017317152.2 → XP_017172641.1  cell surface glycoprotein CD200 receptor 3 isoform X4

    UniProtKB/TrEMBL
    E9Q7T2

  7. XM_006522674.4 → XP_006522737.1  cell surface glycoprotein CD200 receptor 3 isoform X4

    See identical proteins and their annotated locations for XP_006522737.1

    UniProtKB/TrEMBL
    E9Q7T2
    Related
    ENSMUSP00000110260.3, ENSMUST00000114613.9

  8. XM_017317154.2 → XP_017172643.1  cell surface glycoprotein CD200 receptor 3 isoform X6

    UniProtKB/Swiss-Prot
    Q5UKY4
    Related
    ENSMUSP00000110259.2, ENSMUST00000114612.8

  9. XM_011246033.2 → XP_011244335.1  cell surface glycoprotein CD200 receptor 3 isoform X5

    UniProtKB/TrEMBL
    E9Q7T2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5UKY4.1 GenPept UniProtKB/Swiss-Prot:Q5UKY4

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