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Pyroxd2 pyridine nucleotide-disulphide oxidoreductase domain 2 [ Mus musculus (house mouse) ]

Gene ID: 74580, updated on 2-Nov-2024

Summary

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Official Symbol
Pyroxd2provided by MGI
Official Full Name
pyridine nucleotide-disulphide oxidoreductase domain 2provided by MGI
Primary source
MGI:MGI:1921830
See related
Ensembl:ENSMUSG00000060224 AllianceGenome:MGI:1921830
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3830409H07Rik; 4833409A17Rik
Summary
Predicted to enable oxidoreductase activity. Predicted to be involved in mitochondrion organization. Predicted to be located in mitochondrial matrix. Orthologous to human PYROXD2 (pyridine nucleotide-disulphide oxidoreductase domain 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in kidney adult (RPKM 27.6), adrenal adult (RPKM 17.2) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Pyroxd2 in Genome Data Viewer
Location:
19 C3; 19 36.56 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (42714296..42741261, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (42725857..42752823, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_46188 Neighboring gene lysyl oxidase-like 4 Neighboring gene predicted gene, 25216 Neighboring gene predicted gene, 19437 Neighboring gene predicted gene 16244 Neighboring gene HPS1, biogenesis of lysosomal organelles complex 3 subunit 1 Neighboring gene heparanase 2 Neighboring gene STARR-seq mESC enhancer starr_46190 Neighboring gene STARR-seq mESC enhancer starr_46192 Neighboring gene STARR-seq mESC enhancer starr_46193 Neighboring gene high mobility group box 3 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity. Wang S, et al. PLoS Genet, 2006 Feb. PMID 16462940, Free PMC Article
  2. Integrating genetic and network analysis to characterize genes related to mouse weight. Ghazalpour A, et al. PLoS Genet, 2006 Aug 18. PMID 16934000, Free PMC Article
  3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrion organization ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrion organization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029011.2 → NP_083287.2  pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2

    See identical proteins and their annotated locations for NP_083287.2

    Status: VALIDATED

    Source sequence(s)
    AK038414, AK160239, CB573340, CX218741
    Consensus CDS
    CCDS37991.1
    UniProtKB/Swiss-Prot
    E9QPD2, Q3U4I7, Q8CAN2, Q9D630
    UniProtKB/TrEMBL
    A0A494BA58
    Related
    ENSMUSP00000075825.4, ENSMUST00000076505.4
    Conserved Domains (2) summary
    COG1233
    Location:33 → 580
    COG1233; Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism]
    cl21454
    Location:35 → 578
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    42714296..42741261 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161713.1 → XP_036017606.1  pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A494BA58
    Conserved Domains (1) summary
    COG1233
    Location:33 → 632
    COG1233; Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism]

  2. XM_036161714.1 → XP_036017607.1  pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A494BA58
    Conserved Domains (1) summary
    COG1233
    Location:33 → 629
    COG1233; Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism]

  3. XM_011247383.4 → XP_011245685.1  pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A494BA58
    Conserved Domains (1) summary
    COG1233
    Location:33 → 583
    COG1233; Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism]

RNA

  1. XR_003952824.2 RNA Sequence

  2. XR_004940178.1 RNA Sequence

  3. XR_877691.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U4I7.3 GenPept UniProtKB/Swiss-Prot:Q3U4I7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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