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Elovl7 ELOVL fatty acid elongase 7 [ Mus musculus (house mouse) ]

Gene ID: 74559, updated on 28-Oct-2024

Summary

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Official Symbol
Elovl7provided by MGI
Official Full Name
ELOVL fatty acid elongase 7provided by MGI
Primary source
MGI:MGI:1921809
See related
Ensembl:ENSMUSG00000021696 AllianceGenome:MGI:1921809
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9130013K24Rik
Summary
Predicted to enable fatty acid elongase activity. Predicted to be involved in fatty acid biosynthetic process and sphingolipid biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Is expressed in 4th ventricle lateral recess; choroid plexus; lateral ventricle choroid plexus; and skin. Orthologous to human ELOVL7 (ELOVL fatty acid elongase 7). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in large intestine adult (RPKM 5.6), kidney adult (RPKM 5.5) and 16 other tissues See more
Orthologs
human all
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Genomic context

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See Elovl7 in Genome Data Viewer
Location:
13 D2.1; 13 59.69 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (108350860..108423643)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (108214326..108287109)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 2 Neighboring gene STARR-positive B cell enhancer mm9_chr13:108943188-108943489 Neighboring gene predicted gene, 52057 Neighboring gene STARR-positive B cell enhancer ABC_E5415 Neighboring gene excision repaiross-complementing rodent repair deficiency, complementation group 8 Neighboring gene STARR-seq mESC enhancer starr_35596 Neighboring gene predicted gene, 32376 Neighboring gene predicted gene, 30747 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:109087570-109087807 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:109087883-109088036 Neighboring gene STARR-positive B cell enhancer mm9_chr13:109106315-109106616 Neighboring gene neuroepithelial cell transforming gene 1 pseudogene Neighboring gene DEP domain containing 1B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Reactivation of androgen receptor-regulated lipid biosynthesis drives the progression of castration-resistant prostate cancer. Han W, et al. Oncogene, 2018 Feb 8. PMID 29059155, Free PMC Article
  2. Production of branched-chain very-long-chain fatty acids by fatty acid elongases and their tissue distribution in mammals. Tanno H, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2021 Jan. PMID 33069870
  3. Impaired epidermal permeability barrier in mice lacking elovl1, the gene responsible for very-long-chain fatty acid production. Sassa T, et al. Mol Cell Biol, 2013 Jul. PMID 23689133, Free PMC Article
  4. The Transcription Factors EBF1 and EBF2 Are Positive Regulators of Myelination in Schwann Cells. Moruzzo D, et al. Mol Neurobiol, 2017 Dec. PMID 27889898
  5. Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil. Lau CG, et al. Mol Reprod Dev, 2014 Nov. PMID 25269881

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Production of branched-chain very-long-chain fatty acids by fatty acid elongases and their tissue distribution in mammals.
    Title: Production of branched-chain very-long-chain fatty acids by fatty acid elongases and their tissue distribution in mammals.
  2. High Elovl7 expression is associated with progression of castration-resistant prostate cancer.
    Title: Reactivation of androgen receptor-regulated lipid biosynthesis drives the progression of castration-resistant prostate cancer.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables fatty acid elongase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fatty acid elongase activity IEA
Inferred from Electronic Annotation
more info
  
enables fatty acid elongase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in fatty acid elongation, monounsaturated fatty acid IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid elongation, monounsaturated fatty acid IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid elongation, polyunsaturated fatty acid IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid elongation, polyunsaturated fatty acid IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid elongation, polyunsaturated fatty acid ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid elongation, saturated fatty acid IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid elongation, saturated fatty acid ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid elongation, saturated fatty acid ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in long-chain fatty-acyl-CoA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sphingolipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in unsaturated fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in very long-chain fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in very long-chain fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in very long-chain fatty acid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
very long chain fatty acid elongase 7
Names
3-keto acyl-CoA synthase Elovl7
ELOVL FA elongase 7
ELOVL family member 7, elongation of long chain fatty acids
elongation of very long chain fatty acids protein 7
elongation of very long chain fatty acids-like 7
very long chain 3-ketoacyl-CoA synthase 7
very long chain 3-oxoacyl-CoA synthase 7
NP_083277.3
XP_006517841.1
XP_036014092.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029001.5 → NP_083277.3  very long chain fatty acid elongase 7

    See identical proteins and their annotated locations for NP_083277.3

    Status: VALIDATED

    Source sequence(s)
    AC161252, AK018616, AK049118, BQ175164
    Consensus CDS
    CCDS36779.1
    UniProtKB/Swiss-Prot
    Q8BX38, Q8BYY8, Q9D2Y9
    Related
    ENSMUSP00000022207.9, ENSMUST00000022207.10
    Conserved Domains (1) summary
    pfam01151
    Location:30 → 269
    ELO; GNS1/SUR4 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    108350860..108423643
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517778.4 → XP_006517841.1  very long chain fatty acid elongase 7 isoform X2

    Conserved Domains (1) summary
    pfam01151
    Location:1 → 182
    ELO; GNS1/SUR4 family

  2. XM_036158199.1 → XP_036014092.1  very long chain fatty acid elongase 7 isoform X1

    Conserved Domains (1) summary
    pfam01151
    Location:1 → 239
    ELO; GNS1/SUR4 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D2Y9.1 GenPept UniProtKB/Swiss-Prot:Q9D2Y9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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