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Morc2a microrchidia 2A [ Mus musculus (house mouse) ]

Gene ID: 74522, updated on 2-Nov-2024

Summary

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Official Symbol
Morc2aprovided by MGI
Official Full Name
microrchidia 2Aprovided by MGI
Primary source
MGI:MGI:1921772
See related
Ensembl:ENSMUSG00000034543 AllianceGenome:MGI:1921772
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zcwcc1; 8430403M08Rik
Summary
Enables histone binding activity. Involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate and positive regulation of DNA methylation-dependent heterochromatin formation. Predicted to be located in cytosol; heterochromatin; and nuclear lumen. Predicted to be active in nucleus. Is expressed in gonad; heart; nervous system; and skeletal muscle. Used to study Charcot-Marie-Tooth disease axonal type 2Z. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2Z. Orthologous to human MORC2 (MORC family CW-type zinc finger 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 13.7), CNS E14 (RPKM 13.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Morc2a in Genome Data Viewer
Location:
11 A1; 11 2.56 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (3599132..3640477)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (3649189..3690477)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11951 Neighboring gene STARR-positive B cell enhancer ABC_E6944 Neighboring gene STARR-seq mESC enhancer starr_28362 Neighboring gene taurine upregulated gene 1 Neighboring gene STARR-seq mESC enhancer starr_28363 Neighboring gene nucleolar and spindle associated protein 1 pseudogene Neighboring gene oxysterol binding protein 2 Neighboring gene predicted gene, 51881

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Morc2a p.S87L mutant mice develop peripheral and central neuropathies associated with neuronal DNA damage and apoptosis. Lee GS, et al. Dis Model Mech, 2021 Oct 1. PMID 34695197, Free PMC Article
  2. Morc2a variants cause hydroxyl radical-mediated neuropathy and are rescued by restoring GHKL ATPase. Chung HY, et al. Brain, 2024 Jun 3. PMID 38227798
  3. Cytosolic functions of MORC2 in lipogenesis and adipogenesis. Sánchez-Solana B, et al. Biochim Biophys Acta, 2014 Feb. PMID 24286864, Free PMC Article
  4. Characterization of molecular mechanisms underlying the axonal Charcot-Marie-Tooth neuropathy caused by MORC2 mutations. Sancho P, et al. Hum Mol Genet, 2019 May 15. PMID 30624633
  5. The HUSH complex controls brain architecture and protocadherin fidelity. Hagelkruys A, et al. Sci Adv, 2022 Nov 4. PMID 36332029, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Morc2a variants cause hydroxyl radical-mediated neuropathy and are rescued by restoring GHKL ATPase.
    Title: Morc2a variants cause hydroxyl radical-mediated neuropathy and are rescued by restoring GHKL ATPase.
  2. Morc2a p.S87L mutant mice develop peripheral and central neuropathies associated with neuronal DNA damage and apoptosis.
    Title: Morc2a p.S87L mutant mice develop peripheral and central neuropathies associated with neuronal DNA damage and apoptosis.
  3. We characterized two factors, MORC2A and RESF1, of which RESF1 is a novel molecule in retroelement silencing. Although both factors are recruited to repress provirus, their roles in repression are different. MORC2A appears to function dependent on repressive epigenetic modifications, while RESF1 regulates repressive epigenetic modifications associated with SETDB1
    Title: A CRISPR knockout screen identifies SETDB1-target retroelement silencing factors in embryonic stem cells.
  4. these results demonstrate a cytosolic function of MORC2 in lipogenesis, adipogenic differentiation, and lipid homeostasis by regulating the activity of ACLY.[Morc2]
    Title: Cytosolic functions of MORC2 in lipogenesis and adipogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA damage response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of gene expression, epigenetic ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression, epigenetic ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of DNA methylation-dependent heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA methylation-dependent heterochromatin formation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA methylation-dependent heterochromatin formation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in heterochromatin ISO
Inferred from Sequence Orthology
more info
  
located_in heterochromatin ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear matrix ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
ATPase MORC2A
Names
MORC family CW-type zinc finger protein 2A
zinc finger CW-type coiled-coil domain protein 1
zinc finger, CW-type with coiled-coil domain 1
NP_001152760.1
NP_001350131.1
NP_937805.1
XP_006514934.1
XP_011242077.1
XP_036012945.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159288.2 → NP_001152760.1  ATPase MORC2A isoform 1

    See identical proteins and their annotated locations for NP_001152760.1

    Status: VALIDATED

    Source sequence(s)
    AK173042, AL691413
    Consensus CDS
    CCDS48741.1
    UniProtKB/Swiss-Prot
    Q5QNQ7, Q69ZX6, Q6P547
    Related
    ENSMUSP00000091087.3, ENSMUST00000093389.9
    Conserved Domains (3) summary
    pfam07496
    Location:495 → 542
    zf-CW; CW-type Zinc Finger
    pfam13589
    Location:29 → 169
    HATPase_c_3; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
    cl26464
    Location:624 → 741
    Atrophin-1; Atrophin-1 family

  2. NM_001363202.1 → NP_001350131.1  ATPase MORC2A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL691413
    Consensus CDS
    CCDS48741.1
    UniProtKB/Swiss-Prot
    Q5QNQ7, Q69ZX6, Q6P547
    Related
    ENSMUSP00000094176.4, ENSMUST00000096441.5
    Conserved Domains (3) summary
    pfam07496
    Location:495 → 542
    zf-CW; CW-type Zinc Finger
    pfam13589
    Location:29 → 169
    HATPase_c_3; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
    cl26464
    Location:624 → 741
    Atrophin-1; Atrophin-1 family

  3. NM_198162.2 → NP_937805.1  ATPase MORC2A isoform 2

    See identical proteins and their annotated locations for NP_937805.1

    Status: VALIDATED

    Source sequence(s)
    AL691413, BC059243
    UniProtKB/TrEMBL
    Q6PCN6
    Conserved Domains (4) summary
    PHA03247
    Location:562 → 679
    PHA03247; large tegument protein UL36; Provisional
    pfam07496
    Location:433 → 480
    zf-CW; CW-type Zinc Finger
    pfam17942
    Location:177 → 389
    Morc6_S5; Morc6 ribosomal protein S5 domain 2-like
    cl00075
    Location:1 → 73
    HATPase; Histidine kinase-like ATPase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    3599132..3640477
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243775.4 → XP_011242077.1  ATPase MORC2A isoform X1

    See identical proteins and their annotated locations for XP_011242077.1

    Conserved Domains (4) summary
    PHA03247
    Location:624 → 741
    PHA03247; large tegument protein UL36; Provisional
    cd16931
    Location:18 → 135
    HATPase_MORC-like; Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains
    pfam07496
    Location:495 → 542
    zf-CW; CW-type Zinc Finger
    pfam17942
    Location:239 → 451
    Morc6_S5; Morc6 ribosomal protein S5 domain 2-like

  2. XM_006514871.4 → XP_006514934.1  ATPase MORC2A isoform X1

    See identical proteins and their annotated locations for XP_006514934.1

    Conserved Domains (4) summary
    PHA03247
    Location:624 → 741
    PHA03247; large tegument protein UL36; Provisional
    cd16931
    Location:18 → 135
    HATPase_MORC-like; Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains
    pfam07496
    Location:495 → 542
    zf-CW; CW-type Zinc Finger
    pfam17942
    Location:239 → 451
    Morc6_S5; Morc6 ribosomal protein S5 domain 2-like

  3. XM_036157052.1 → XP_036012945.1  ATPase MORC2A isoform X2

    UniProtKB/TrEMBL
    Q6PCN6
    Conserved Domains (4) summary
    PHA03247
    Location:562 → 679
    PHA03247; large tegument protein UL36; Provisional
    pfam07496
    Location:433 → 480
    zf-CW; CW-type Zinc Finger
    pfam17942
    Location:177 → 389
    Morc6_S5; Morc6 ribosomal protein S5 domain 2-like
    cl00075
    Location:1 → 73
    HATPase; Histidine kinase-like ATPase domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q69ZX6.2 GenPept UniProtKB/Swiss-Prot:Q69ZX6

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