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Slc9b1 solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1 [ Mus musculus (house mouse) ]

Gene ID: 74446, updated on 17-Aug-2024

Summary

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Official Symbol
Slc9b1provided by MGI
Official Full Name
solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1provided by MGI
Primary source
MGI:MGI:1921696
See related
Ensembl:ENSMUSG00000050150 AllianceGenome:MGI:1921696
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nhedc1; mtsNHE; 1700094G20Rik; 4933424B12Rik; 4933425K02Rik
Summary
Predicted to enable solute:proton antiporter activity. Involved in flagellated sperm motility and regulation of intracellular pH. Located in sperm principal piece. Orthologous to several human genes including SLC9B1 (solute carrier family 9 member B1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 25.1) See more
Orthologs
human all
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Genomic context

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Location:
3 G3; 3 62.55 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (135053754..135103588)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (135347993..135397827)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46826 Neighboring gene 3-hydroxybutyrate dehydrogenase, type 2 Neighboring gene STARR-seq mESC enhancer starr_09056 Neighboring gene solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 Neighboring gene STARR-seq mESC enhancer starr_09057 Neighboring gene STARR-seq mESC enhancer starr_09058 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:135065430-135065659 Neighboring gene CDGSH iron sulfur domain 2 Neighboring gene RIKEN cDNA 4930539J05 gene Neighboring gene STARR-positive B cell enhancer ABC_E1026 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:135101299-135101408 Neighboring gene ubiquitin-conjugating enzyme E2D 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Evolution of Vertebrate Solute Carrier Family 9B Genes and Proteins (SLC9B): Evidence for a Marsupial Origin for Testis Specific SLC9B1 from an Ancestral Vertebrate SLC9B2 Gene. Holmes RS, et al. J Phylogenetics Evol Biol, 2016 Aug. PMID 28868326, Free PMC Article
  2. Immunization with a DNA vaccine of testis-specific sodium-hydrogen exchanger by oral feeding or nasal instillation reduces fertility in female mice. Liu T, et al. Fertil Steril, 2010 Mar 15. PMID 19409551
  3. A novel testis-specific Na+/H+ exchanger is involved in sperm motility and fertility. Liu T, et al. Front Biosci (Elite Ed), 2010 Jan 1. PMID 20036903
  4. Sodium-hydrogen exchanger NHA1 and NHA2 control sperm motility and male fertility. Chen SR, et al. Cell Death Dis, 2016 Mar 24. PMID 27010853, Free PMC Article
  5. Molecular Mechanism Underlying the Action of Zona-pellucida Glycoproteins on Mouse Sperm. Balbach M, et al. Front Cell Dev Biol, 2020. PMID 32984353, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. data revealed that NHA1 and NHA2 function as a key sodium-hydrogen exchanger responsible for sperm motility after leaving the cauda epididymidis.
    Title: Sodium-hydrogen exchanger NHA1 and NHA2 control sperm motility and male fertility.
  2. A novel testis-specific Na+/H+ exchanger, mtsNHE, is involved in sperm motility and fertility.
    Title: A novel testis-specific Na+/H+ exchanger is involved in sperm motility and fertility.
  3. Immunization with a DNA vaccine of testis-specific sodium-hydrogen exchanger (tsNHE) via oral feeding or nasal instillation reduced fertility in female mice.
    Title: Immunization with a DNA vaccine of testis-specific sodium-hydrogen exchanger by oral feeding or nasal instillation reduces fertility in female mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in inorganic cation transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic cation transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of intracellular pH IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within single fertilization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in sperm principal piece IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
sodium/hydrogen exchanger 9B1
Names
NHE domain-containing protein 1
Na(+)/H(+) exchanger-like domain-containing protein 1
Na+/H+ exchanger domain containing 1
sodium/hydrogen exchanger-like domain-containing protein 1
solute carrier family 9 subfamily B member 1
testis specific sodium-hydrogen exchanger

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358057.1 → NP_001344986.1  sodium/hydrogen exchanger 9B1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC104874, AK016917
    Related
    ENSMUST00000160460.8
    Conserved Domains (1) summary
    cl01133
    Location:207 → 355
    Na_H_Exchanger; Sodium/hydrogen exchanger family

  2. NM_028946.4 → NP_083222.2  sodium/hydrogen exchanger 9B1 isoform 1

    See identical proteins and their annotated locations for NP_083222.2

    Status: VALIDATED

    Source sequence(s)
    AC156618, AK029525, AV262918, BX525256
    Consensus CDS
    CCDS17855.2
    UniProtKB/Swiss-Prot
    B5AFL0, Q8C0X2, Q8C1I8, Q8R3N0, Q9CPR9, Q9D400
    UniProtKB/TrEMBL
    G5E8I2
    Related
    ENSMUSP00000077644.6, ENSMUST00000078568.12
    Conserved Domains (1) summary
    cl01133
    Location:207 → 551
    Na_H_Exchanger; Sodium/hydrogen exchanger family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    135053754..135103588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240253.3 → XP_011238555.1  sodium/hydrogen exchanger 9B1 isoform X3

    Conserved Domains (1) summary
    cl01133
    Location:207 → 269
    Na_H_Exchanger; Sodium/hydrogen exchanger family

  2. XM_017319776.1 → XP_017175265.1  sodium/hydrogen exchanger 9B1 isoform X1

    UniProtKB/Swiss-Prot
    B5AFL0, Q8C0X2, Q8C1I8, Q8R3N0, Q9CPR9, Q9D400
    UniProtKB/TrEMBL
    G5E8I2
    Conserved Domains (1) summary
    cl01133
    Location:207 → 551
    Na_H_Exchanger; Sodium/hydrogen exchanger family

  3. XM_017319775.1 → XP_017175264.1  sodium/hydrogen exchanger 9B1 isoform X1

    UniProtKB/Swiss-Prot
    B5AFL0, Q8C0X2, Q8C1I8, Q8R3N0, Q9CPR9, Q9D400
    UniProtKB/TrEMBL
    G5E8I2
    Conserved Domains (1) summary
    cl01133
    Location:207 → 551
    Na_H_Exchanger; Sodium/hydrogen exchanger family

  4. XM_011240251.2 → XP_011238553.1  sodium/hydrogen exchanger 9B1 isoform X1

    See identical proteins and their annotated locations for XP_011238553.1

    UniProtKB/Swiss-Prot
    B5AFL0, Q8C0X2, Q8C1I8, Q8R3N0, Q9CPR9, Q9D400
    UniProtKB/TrEMBL
    G5E8I2
    Conserved Domains (1) summary
    cl01133
    Location:207 → 551
    Na_H_Exchanger; Sodium/hydrogen exchanger family

  5. XM_006502201.3 → XP_006502264.1  sodium/hydrogen exchanger 9B1 isoform X1

    See identical proteins and their annotated locations for XP_006502264.1

    UniProtKB/Swiss-Prot
    B5AFL0, Q8C0X2, Q8C1I8, Q8R3N0, Q9CPR9, Q9D400
    UniProtKB/TrEMBL
    G5E8I2
    Conserved Domains (1) summary
    cl01133
    Location:207 → 551
    Na_H_Exchanger; Sodium/hydrogen exchanger family

  6. XM_011240252.2 → XP_011238554.1  sodium/hydrogen exchanger 9B1 isoform X2

    Conserved Domains (1) summary
    cl01133
    Location:207 → 400
    Na_H_Exchanger; Sodium/hydrogen exchanger family

RNA

  1. XR_867240.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C0X2.1 GenPept UniProtKB/Swiss-Prot:Q8C0X2

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