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Tspan17 tetraspanin 17 [ Mus musculus (house mouse) ]

Gene ID: 74257, updated on 2-Nov-2024

Summary

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Official Symbol
Tspan17provided by MGI
Official Full Name
tetraspanin 17provided by MGI
Primary source
MGI:MGI:1921507
See related
Ensembl:ENSMUSG00000025875 AllianceGenome:MGI:1921507
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fbxo23; Tm4sf17; 2210021G21Rik
Summary
Enables enzyme binding activity. Involved in protein maturation. Predicted to be active in plasma membrane. Is expressed in brain; ganglia; neural retina; and ventral grey horn. Orthologous to human TSPAN17 (tetraspanin 17). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 15.8), cerebellum adult (RPKM 14.7) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Tspan17 in Genome Data Viewer
Location:
13 B1; 13 29.41 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (54936915..54944588)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (54789102..54796775)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_34592 Neighboring gene predicted gene 16249 Neighboring gene STARR-positive B cell enhancer mm9_chr13:54890539-54890840 Neighboring gene eukaryotic translation initiation factor 4E family member 1B Neighboring gene predicted gene, 40959 Neighboring gene predicted gene, 31188

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Atrogin-1 and MuRF1 regulate cardiac MyBP-C levels via different mechanisms. Mearini G, et al. Cardiovasc Res, 2010 Jan 15. PMID 19850579, Free PMC Article
  2. The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression. Haining EJ, et al. J Biol Chem, 2012 Nov 16. PMID 23035126, Free PMC Article
  3. Appearance of new tetraspanin genes during vertebrate evolution. Garcia-España A, et al. Genomics, 2008 Apr. PMID 18291621
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in establishment of protein localization to organelle ISO
Inferred from Sequence Orthology
more info
  
involved_in protein maturation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of membrane protein ectodomain proteolysis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tetraspanin-17
Names
F-box only protein 23
tetraspan protein SB134
transmembrane 4 superfamily member 17
tspan-17
NP_083117.2
XP_006517477.1
XP_006517478.1
XP_006517480.1
XP_017171106.1
XP_017171107.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028841.3 → NP_083117.2  tetraspanin-17

    See identical proteins and their annotated locations for NP_083117.2

    Status: VALIDATED

    Source sequence(s)
    AI019499, AK008761, BY734818, CD740983
    Consensus CDS
    CCDS26536.1
    UniProtKB/Swiss-Prot
    Q91VI6, Q9D7W4
    UniProtKB/TrEMBL
    Q3TAQ3
    Related
    ENSMUSP00000026993.8, ENSMUST00000026993.14
    Conserved Domains (2) summary
    cd03159
    Location:115 → 235
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:16 → 263
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    54936915..54944588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517414.3 → XP_006517477.1  tetraspanin-17 isoform X1

    See identical proteins and their annotated locations for XP_006517477.1

    UniProtKB/Swiss-Prot
    Q91VI6, Q9D7W4
    Related
    ENSMUSP00000115287.3, ENSMUST00000131692.9
    Conserved Domains (1) summary
    cd03159
    Location:115 → 235
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

  2. XM_006517415.3 → XP_006517478.1  tetraspanin-17 isoform X2

    UniProtKB/Swiss-Prot
    Q91VI6, Q9D7W4
    Conserved Domains (2) summary
    cd03159
    Location:115 → 210
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:18 → 191
    Tetraspannin; Tetraspanin family

  3. XM_017315617.2 → XP_017171106.1  tetraspanin-17 isoform X3

    UniProtKB/TrEMBL
    F6VW20
    Related
    ENSMUSP00000123607.3, ENSMUST00000130568.9
    Conserved Domains (2) summary
    cd03159
    Location:115 → 194
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:18 → 191
    Tetraspannin; Tetraspanin family

  4. XM_006517417.4 → XP_006517480.1  tetraspanin-17 isoform X5

    Conserved Domains (2) summary
    cl02781
    Location:115 → 194
    tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
    pfam00335
    Location:18 → 191
    Tetraspannin; Tetraspanin family

  5. XM_017315618.2 → XP_017171107.1  tetraspanin-17 isoform X4

    UniProtKB/TrEMBL
    E9PWC3
    Related
    ENSMUSP00000131671.2, ENSMUST00000163796.8
    Conserved Domains (1) summary
    cd03159
    Location:49 → 169
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

RNA

  1. XR_382461.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D7W4.1 GenPept UniProtKB/Swiss-Prot:Q9D7W4

Gene LinkOut

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