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Smu1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) [ Mus musculus (house mouse) ]

Gene ID: 74255, updated on 2-Nov-2024

Summary

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Official Symbol
Smu1provided by MGI
Official Full Name
smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)provided by MGI
Primary source
MGI:MGI:1915546
See related
Ensembl:ENSMUSG00000028409 AllianceGenome:MGI:1915546
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bwd; 2600001O03Rik; 2610203K23Rik
Summary
Predicted to be involved in mRNA splicing, via spliceosome and regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in nuclear speck. Predicted to be part of U2-type precatalytic spliceosome. Is expressed in several structures, including central nervous system; genitourinary system; liver; otocyst; and retina. Orthologous to human SMU1 (SMU1 DNA replication regulator and spliceosomal factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 30.9), placenta adult (RPKM 27.4) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Smu1 in Genome Data Viewer
Location:
4 A5; 4 20.46 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (40735649..40757885, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (40735649..40757885, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1272 Neighboring gene predicted gene 6297 Neighboring gene DnaJ heat shock protein family (Hsp40) member A1 Neighboring gene microRNA 207 Neighboring gene STARR-positive B cell enhancer ABC_E7962 Neighboring gene STARR-positive B cell enhancer ABC_E4617 Neighboring gene STARR-seq mESC enhancer starr_09993 Neighboring gene presenilin enhancer gamma secretase subunit, pseudogene Neighboring gene predicted gene, 34213 Neighboring gene UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 Neighboring gene STARR-seq mESC enhancer starr_09997 Neighboring gene STARR-positive B cell enhancer ABC_E11234 Neighboring gene microRNA 5123

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification and analysis of genes from the mouse otic vesicle and their association with developmental subprocesses through in situ hybridization. Powles N, et al. Dev Biol, 2004 Apr 1. PMID 15031102
  2. Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. Grebien F, et al. Nat Chem Biol, 2015 Aug. PMID 26167872, Free PMC Article
  3. Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development. Combes AN, et al. Dev Dyn, 2009 May. PMID 19334288, Free PMC Article
  4. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article
  5. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of U2-type precatalytic spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of U2-type precatalytic spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of precatalytic spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
WD40 repeat-containing protein SMU1
Names
smu-1 suppressor of mec-8 and unc-52 protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021535.4 → NP_067510.3  WD40 repeat-containing protein SMU1

    See identical proteins and their annotated locations for NP_067510.3

    Status: VALIDATED

    Source sequence(s)
    AK145982, AK163758, AK168813, BY036103
    Consensus CDS
    CCDS18050.1
    UniProtKB/Swiss-Prot
    Q3UKJ7, Q6PFR6, Q8BMY4, Q9D1I8, Q9JJ70
    Related
    ENSMUSP00000030117.5, ENSMUST00000030117.5
    Conserved Domains (5) summary
    smart00668
    Location:40 → 90
    CTLH; C-terminal to LisH motif
    COG4598
    Location:102 → 218
    HisP; ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]
    cd00200
    Location:205 → 512
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:219 → 262
    7WD40; WD40 repeat [structural motif]
    pfam17814
    Location:7 → 36
    LisH_TPL; LisH-like dimerisation domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    40735649..40757885 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UKJ7.2 GenPept UniProtKB/Swiss-Prot:Q3UKJ7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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