U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Chpf chondroitin polymerizing factor [ Mus musculus (house mouse) ]

Gene ID: 74241, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Chpfprovided by MGI
Official Full Name
chondroitin polymerizing factorprovided by MGI
Primary source
MGI:MGI:106576
See related
Ensembl:ENSMUSG00000032997 AllianceGenome:MGI:106576
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D1Bwg1363e; 1700028N03Rik
Summary
Enables N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity and glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity. Acts upstream of or within chondroitin sulfate biosynthetic process. Is active in Golgi apparatus. Is expressed in articular cartilage; cartilage; cerebral cortex; and humerus. Orthologous to human CHPF (chondroitin polymerizing factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in ovary adult (RPKM 121.4), adrenal adult (RPKM 100.6) and 24 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Chpf in Genome Data Viewer
Location:
1 C4; 1 39.14 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (75451213..75456115, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (75474569..75479471, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene GDP-mannose pyrophosphorylase A Neighboring gene STARR-seq mESC enhancer starr_01359 Neighboring gene predicted gene, 53564 Neighboring gene acid-sensing ion channel family member 4 Neighboring gene predicted gene, 32506 Neighboring gene STARR-positive B cell enhancer ABC_E1997 Neighboring gene transmembrane protein 198 Neighboring gene obscurin-like 1 Neighboring gene STARR-seq mESC enhancer starr_01360 Neighboring gene inhibin alpha

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Chondroitin sulfate synthase-2/chondroitin polymerizing factor has two variants with distinct function. Ogawa H, et al. J Biol Chem, 2010 Oct 29. PMID 20729547, Free PMC Article
  2. Involvement of chondroitin sulfate synthase-3 (chondroitin synthase-2) in chondroitin polymerization through its interaction with chondroitin synthase-1 or chondroitin-polymerizing factor. Izumikawa T, et al. Biochem J, 2007 May 1. PMID 17253960, Free PMC Article
  3. Gene network and pathway analysis of mice with conditional ablation of Dicer in post-mitotic neurons. Dorval V, et al. PLoS One, 2012. PMID 22952873, Free PMC Article
  4. MiR-214-3p overexpression-triggered chondroitin polymerizing factor (CHPF) inhibition modulates the ferroptosis and metabolism in colon cancer. Yun ZY, et al. Kaohsiung J Med Sci, 2024 Mar. PMID 38190270
  5. Parkin interacts with Klokin1 for mitochondrial import and maintenance of membrane potential. Kuroda Y, et al. Hum Mol Genet, 2012 Mar 1. PMID 22082830

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MiR-214-3p overexpression-triggered chondroitin polymerizing factor (CHPF) inhibition modulates the ferroptosis and metabolism in colon cancer.
    Title: MiR-214-3p overexpression-triggered chondroitin polymerizing factor (CHPF) inhibition modulates the ferroptosis and metabolism in colon cancer.
  2. CSS2 mainly participated in the extension of chondroitin sulfate
    Title: Chondroitin sulfate synthase-2 is necessary for chain extension of chondroitin sulfate but not critical for skeletal development.
  3. Chondroitin sulfate synthase-2/chondroitin polymerizing factor has two variants with distinct function
    Title: Chondroitin sulfate synthase-2/chondroitin polymerizing factor has two variants with distinct function.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chondroitin sulfate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within chondroitin sulfate biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in chondroitin sulfate biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within chondroitin sulfate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chondroitin sulfate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
chondroitin sulfate synthase 2
Names
N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase II
N-acetylgalactosaminyltransferase 2
chondroitin glucuronyltransferase 2
glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II
NP_001001565.1
NP_001001566.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001565.2 → NP_001001565.1  chondroitin sulfate synthase 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate exon in the coding region and uses a downstream AUG compared to variant 1. The resulting isoform (b) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC115011, BB651806, BC060598, BC071273
    Consensus CDS
    CCDS15075.1
    UniProtKB/Swiss-Prot
    Q6IQX7
    Related
    ENSMUSP00000092412.3, ENSMUST00000094818.4
    Conserved Domains (2) summary
    pfam05679
    Location:100 → 599
    CHGN; Chondroitin N-acetylgalactosaminyltransferase
    cl21608
    Location:32 → 121
    Galactosyl_T; Galactosyltransferase

  2. NM_001001566.3 → NP_001001566.1  chondroitin sulfate synthase 2 isoform a

    See identical proteins and their annotated locations for NP_001001566.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC115011, BC071273
    Consensus CDS
    CCDS15074.1
    UniProtKB/Swiss-Prot
    E9PUB9, Q6IQX7
    Related
    ENSMUSP00000078199.8, ENSMUST00000079205.14
    Conserved Domains (2) summary
    pfam05679
    Location:262 → 761
    CHGN; Chondroitin N-acetylgalactosaminyltransferase
    cl21608
    Location:194 → 283
    Galactosyl_T; Galactosyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    75451213..75456115 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6IQX7.1 GenPept UniProtKB/Swiss-Prot:Q6IQX7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous