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Iqce IQ motif containing E [ Mus musculus (house mouse) ]

Gene ID: 74239, updated on 2-Nov-2024

Summary

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Official Symbol
Iqceprovided by MGI
Official Full Name
IQ motif containing Eprovided by MGI
Primary source
MGI:MGI:1921489
See related
Ensembl:ENSMUSG00000036555 AllianceGenome:MGI:1921489
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1023; 1700028P05Rik
Summary
Involved in positive regulation of transcription by RNA polymerase II; protein localization to motile cilium; and regulation of smoothened signaling pathway. Located in ciliary membrane and cytoplasmic side of plasma membrane. Part of plasma membrane protein complex. Orthologous to human IQCE (IQ motif containing E). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 22.3), CNS E18 (RPKM 6.5) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Iqce in Genome Data Viewer
Location:
5 G2; 5 79.2 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (140648308..140688158, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (140662553..140702403, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:141093710-141094027 Neighboring gene STARR-positive B cell enhancer ABC_E11729 Neighboring gene LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Neighboring gene tweety family member 3 Neighboring gene STARR-positive B cell enhancer ABC_E6392 Neighboring gene STARR-positive B cell enhancer ABC_E11307 Neighboring gene BRCA1-associated ATM activator 1 Neighboring gene archaelysin family metallopeptidase 1 Neighboring gene predicted gene, 30745

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. EFCAB7 and IQCE regulate hedgehog signaling by tethering the EVC-EVC2 complex to the base of primary cilia. Pusapati GV, et al. Dev Cell, 2014 Mar 10. PMID 24582806, Free PMC Article
  2. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in limb morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in limb morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to motile cilium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in ciliary membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
part_of plasma membrane protein complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
IQ domain-containing protein E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347517.1 → NP_001334446.1  IQ domain-containing protein E isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame exon and lacks another alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC110253
    Consensus CDS
    CCDS84987.1
    UniProtKB/Swiss-Prot
    Q6PCQ0
    Related
    ENSMUSP00000077050.6, ENSMUST00000077890.12

  2. NM_028833.3 → NP_083109.2  IQ domain-containing protein E isoform 1

    See identical proteins and their annotated locations for NP_083109.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC110253
    Consensus CDS
    CCDS39358.1
    UniProtKB/Swiss-Prot
    Q6PCQ0, Q8CDZ1, Q9D9U3
    Related
    ENSMUSP00000045913.8, ENSMUST00000041783.14
    Conserved Domains (2) summary
    smart00015
    Location:553 → 573
    IQ; Calmodulin-binding motif
    pfam01486
    Location:399 → 476
    K-box; K-box region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    140648308..140688158 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254853.1 → XP_030110713.1  IQ domain-containing protein E isoform X7

    Conserved Domains (2) summary
    COG1196
    Location:167 → 436
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15921
    Location:93 → 693
    CCDC158; Coiled-coil domain-containing protein 158

  2. XM_006504742.4 → XP_006504805.1  IQ domain-containing protein E isoform X4

    Conserved Domains (2) summary
    PHA03247
    Location:448 → 765
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:167 → 436
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  3. XM_036165559.1 → XP_036021452.1  IQ domain-containing protein E isoform X10

    Conserved Domains (3) summary
    PLN03209
    Location:469 → 708
    PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
    smart00015
    Location:451 → 471
    IQ; Calmodulin-binding motif
    COG1196
    Location:167 → 453
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  4. XM_006504741.4 → XP_006504804.1  IQ domain-containing protein E isoform X3

    Conserved Domains (2) summary
    PHA03247
    Location:475 → 792
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:380 → 461
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  5. XM_006504744.4 → XP_006504807.1  IQ domain-containing protein E isoform X5

    Conserved Domains (3) summary
    PLN03209
    Location:514 → 753
    PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
    smart00015
    Location:496 → 516
    IQ; Calmodulin-binding motif
    COG1196
    Location:212 → 498
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  6. XM_006504745.4 → XP_006504808.1  IQ domain-containing protein E isoform X9

    Conserved Domains (2) summary
    smart00015
    Location:553 → 573
    IQ; Calmodulin-binding motif
    COG1196
    Location:212 → 481
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  7. XM_006504740.4 → XP_006504803.1  IQ domain-containing protein E isoform X2

    Conserved Domains (2) summary
    PHA03247
    Location:493 → 805
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:212 → 565
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  8. XM_006504739.4 → XP_006504802.1  IQ domain-containing protein E isoform X1

    Conserved Domains (2) summary
    PHA03247
    Location:493 → 810
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:212 → 565
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  9. XM_006504746.4 → XP_006504809.1  IQ domain-containing protein E isoform X14

    Conserved Domains (2) summary
    PHA03247
    Location:254 → 571
    PHA03247; large tegument protein UL36; Provisional
    TIGR02169
    Location:18 → 241
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  10. XM_030254857.1 → XP_030110717.1  IQ domain-containing protein E isoform X14

    Conserved Domains (2) summary
    PHA03247
    Location:254 → 571
    PHA03247; large tegument protein UL36; Provisional
    TIGR02169
    Location:18 → 241
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  11. XM_036165558.1 → XP_036021451.1  IQ domain-containing protein E isoform X8

    Conserved Domains (2) summary
    smart00015
    Location:496 → 516
    IQ; Calmodulin-binding motif
    COG1196
    Location:212 → 498
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  12. XM_030254859.2 → XP_030110719.1  IQ domain-containing protein E isoform X18

    Conserved Domains (3) summary
    PHA03247
    Location:185 → 502
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:90 → 171
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:61 → 257
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  13. XM_030254858.1 → XP_030110718.1  IQ domain-containing protein E isoform X16

    Conserved Domains (4) summary
    smart00015
    Location:314 → 334
    IQ; Calmodulin-binding motif
    PHA03307
    Location:239 → 512
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:4 → 242
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd22307
    Location:201 → 343
    Adgb_C_mid-like; C-terminal middle region of Androglobins (Adgbs) and related proteins; including permuted globin domain and IQ motif

  14. XM_030254856.1 → XP_030110716.1  IQ domain-containing protein E isoform X13

    Conserved Domains (2) summary
    COG1196
    Location:102 → 371
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15921
    Location:28 → 628
    CCDC158; Coiled-coil domain-containing protein 158

  15. XM_030254855.1 → XP_030110715.1  IQ domain-containing protein E isoform X12

    Conserved Domains (3) summary
    PLN03209
    Location:449 → 688
    PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
    smart00015
    Location:431 → 451
    IQ; Calmodulin-binding motif
    COG1196
    Location:147 → 433
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  16. XM_030254854.1 → XP_030110714.1  IQ domain-containing protein E isoform X11

    Conserved Domains (2) summary
    COG1196
    Location:147 → 416
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15921
    Location:73 → 673
    CCDC158; Coiled-coil domain-containing protein 158

  17. XM_030254852.1 → XP_030110712.1  IQ domain-containing protein E isoform X6

    Conserved Domains (2) summary
    PHA03247
    Location:428 → 745
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:147 → 416
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  18. XM_036165562.1 → XP_036021455.1  IQ domain-containing protein E isoform X16

    Conserved Domains (4) summary
    smart00015
    Location:314 → 334
    IQ; Calmodulin-binding motif
    PHA03307
    Location:239 → 512
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:4 → 242
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd22307
    Location:201 → 343
    Adgb_C_mid-like; C-terminal middle region of Androglobins (Adgbs) and related proteins; including permuted globin domain and IQ motif

  19. XM_036165560.1 → XP_036021453.1  IQ domain-containing protein E isoform X15

    Conserved Domains (3) summary
    PHA03247
    Location:236 → 553
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:141 → 222
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:112 → 308
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  20. XM_006504748.2 → XP_006504811.1  IQ domain-containing protein E isoform X17

    Conserved Domains (2) summary
    PHA03247
    Location:217 → 534
    PHA03247; large tegument protein UL36; Provisional
    TIGR02169
    Location:10 → 204
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PCQ0.1 GenPept UniProtKB/Swiss-Prot:Q6PCQ0

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