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Unkl unkempt family like zinc finger [ Mus musculus (house mouse) ]

Gene ID: 74154, updated on 2-Nov-2024

Summary

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Official Symbol
Unklprovided by MGI
Official Full Name
unkempt family like zinc fingerprovided by MGI
Primary source
MGI:MGI:1921404
See related
Ensembl:ENSMUSG00000015127 AllianceGenome:MGI:1921404
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1300004G08Rik
Summary
Predicted to enable metal ion binding activity and transferase activity. Predicted to be involved in protein ubiquitination. Predicted to be located in cytosol. Is expressed in ganglia and liver lobe. Orthologous to human UNKL (unk like zinc finger). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 12.9), liver E14.5 (RPKM 10.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Unkl in Genome Data Viewer
Location:
17 A3.3; 17 12.53 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25407336..25453417)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25188361..25234443)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 154 Neighboring gene intestine-critical region regulatory element Neighboring gene proline and glutamate rich with coiled coil 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:25321285-25321526 Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 4 Neighboring gene predicted gene, 52286 Neighboring gene N-acetylglucosamine-1-phosphotransferase, gamma subunit Neighboring gene TSR3 20S rRNA accumulation Neighboring gene BAI1-associated protein 3 Neighboring gene microRNA 3547

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Unkempt is negatively regulated by mTOR and uncouples neuronal differentiation from growth control. Avet-Rochex A, et al. PLoS Genet, 2014 Sep. PMID 25210733, Free PMC Article
  2. The zinc finger/RING domain protein Unkempt regulates cognitive flexibility. Vinsland E, et al. Sci Rep, 2021 Aug 11. PMID 34381067, Free PMC Article
  3. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC102273

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative E3 ubiquitin-protein ligase UNKL

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001197024.1 → NP_001183953.1  putative E3 ubiquitin-protein ligase UNKL isoform 1

    See identical proteins and their annotated locations for NP_001183953.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
    Source sequence(s)
    AK004898, BC059910, CJ068427
    Consensus CDS
    CCDS57058.1
    UniProtKB/Swiss-Prot
    Q5FWH2, Q6RUT6, Q9DBK4
    Related
    ENSMUSP00000039670.6, ENSMUST00000039734.12
    Conserved Domains (3) summary
    pfam00642
    Location:286 → 310
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam13863
    Location:564 → 638
    DUF4200; Domain of unknown function (DUF4200)
    pfam13920
    Location:684 → 721
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

  2. NM_001290736.1 → NP_001277665.1  putative E3 ubiquitin-protein ligase UNKL isoform 3

    See identical proteins and their annotated locations for NP_001277665.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon compared to variant 1. The encoded protein (isoform 3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC130711, BC059910
    Consensus CDS
    CCDS70769.1
    UniProtKB/TrEMBL
    E0CYD7
    Related
    ENSMUSP00000124276.2, ENSMUST00000160896.8
    Conserved Domains (3) summary
    pfam00642
    Location:100 → 124
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cl17238
    Location:498 → 535
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    cl26597
    Location:387 → 448
    DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)

  3. NM_001357876.1 → NP_001344805.1  putative E3 ubiquitin-protein ligase UNKL isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC130711
    Conserved Domains (3) summary
    pfam00642
    Location:286 → 310
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cl17238
    Location:608 → 645
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    cl27210
    Location:495 → 563
    Mnd1; Mnd1 family

  4. NM_001357877.1 → NP_001344806.1  putative E3 ubiquitin-protein ligase UNKL isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC130711
    Consensus CDS
    CCDS70769.1
    UniProtKB/TrEMBL
    E0CYD7
    Conserved Domains (3) summary
    pfam00642
    Location:100 → 124
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cl17238
    Location:498 → 535
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    cl26597
    Location:387 → 448
    DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)

  5. NM_028789.3 → NP_083065.1  putative E3 ubiquitin-protein ligase UNKL isoform 2

    See identical proteins and their annotated locations for NP_083065.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC130711
    Consensus CDS
    CCDS28510.1
    UniProtKB/TrEMBL
    B9EKD9
    Related
    ENSMUSP00000015271.6, ENSMUST00000015271.12
    Conserved Domains (2) summary
    cl17238
    Location:196 → 233
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    cl26597
    Location:85 → 146
    DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    25407336..25453417
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525022.5 → XP_006525085.1  putative E3 ubiquitin-protein ligase UNKL isoform X1

    Conserved Domains (4) summary
    cd00162
    Location:601 → 635
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam00642
    Location:286 → 310
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam18384
    Location:25 → 60
    zf_CCCH_5; Unkempt Zinc finger domain 1 (Znf1)
    cl17238
    Location:599 → 636
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  2. XM_011246684.3 → XP_011244986.1  putative E3 ubiquitin-protein ligase UNKL isoform X2

    See identical proteins and their annotated locations for XP_011244986.1

    UniProtKB/TrEMBL
    E0CYD7
    Conserved Domains (3) summary
    pfam00642
    Location:100 → 124
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cl17238
    Location:498 → 535
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    cl26597
    Location:387 → 448
    DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)

  3. XM_030250117.1 → XP_030105977.1  putative E3 ubiquitin-protein ligase UNKL isoform X7

    UniProtKB/TrEMBL
    B9EKD9
    Conserved Domains (2) summary
    cl17238
    Location:188 → 225
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    cl26597
    Location:77 → 138
    DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)

  4. XM_030250116.1 → XP_030105976.1  putative E3 ubiquitin-protein ligase UNKL isoform X7

    UniProtKB/TrEMBL
    B9EKD9
    Conserved Domains (2) summary
    cl17238
    Location:188 → 225
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    cl26597
    Location:77 → 138
    DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)

  5. XM_030250114.1 → XP_030105974.1  putative E3 ubiquitin-protein ligase UNKL isoform X4

    Conserved Domains (4) summary
    cd00162
    Location:424 → 458
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam00642
    Location:100 → 124
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cl17238
    Location:422 → 459
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    cl26597
    Location:311 → 372
    DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)

  6. XM_030250112.1 → XP_030105972.1  putative E3 ubiquitin-protein ligase UNKL isoform X2

    UniProtKB/TrEMBL
    E0CYD7
    Conserved Domains (3) summary
    pfam00642
    Location:100 → 124
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cl17238
    Location:498 → 535
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    cl26597
    Location:387 → 448
    DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)

  7. XM_030250113.2 → XP_030105973.1  putative E3 ubiquitin-protein ligase UNKL isoform X4

    Conserved Domains (4) summary
    cd00162
    Location:424 → 458
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam00642
    Location:100 → 124
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cl17238
    Location:422 → 459
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    cl26597
    Location:311 → 372
    DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)

  8. XM_030250111.2 → XP_030105971.1  putative E3 ubiquitin-protein ligase UNKL isoform X2

    UniProtKB/TrEMBL
    E0CYD7
    Conserved Domains (3) summary
    pfam00642
    Location:100 → 124
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cl17238
    Location:498 → 535
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    cl26597
    Location:387 → 448
    DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)

  9. XM_017317696.2 → XP_017173185.1  putative E3 ubiquitin-protein ligase UNKL isoform X3

    Conserved Domains (4) summary
    cd00162
    Location:552 → 586
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam00642
    Location:228 → 252
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cl17238
    Location:550 → 587
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    cl26597
    Location:439 → 500
    DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)

  10. XM_030250115.2 → XP_030105975.1  putative E3 ubiquitin-protein ligase UNKL isoform X6

    UniProtKB/TrEMBL
    B9EKD9
    Conserved Domains (2) summary
    cl17238
    Location:196 → 233
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    cl26597
    Location:85 → 146
    DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)

  11. XM_036160816.1 → XP_036016709.1  putative E3 ubiquitin-protein ligase UNKL isoform X5

    Conserved Domains (2) summary
    cd16772
    Location:272 → 309
    RING-HC_UNKL; RING finger, HC subclass, found in RING finger protein unkempt-like (UNKL) and similar proteins
    cl26597
    Location:161 → 222
    DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)

  12. XM_006525024.4 → XP_006525087.1  putative E3 ubiquitin-protein ligase UNKL isoform X5

    Conserved Domains (2) summary
    cd16772
    Location:272 → 309
    RING-HC_UNKL; RING finger, HC subclass, found in RING finger protein unkempt-like (UNKL) and similar proteins
    cl26597
    Location:161 → 222
    DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)

  13. XM_017317697.1 → XP_017173186.1  putative E3 ubiquitin-protein ligase UNKL isoform X7

    UniProtKB/TrEMBL
    B9EKD9
    Conserved Domains (2) summary
    cl17238
    Location:188 → 225
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    cl26597
    Location:77 → 138
    DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)

  14. XM_017317698.2 → XP_017173187.1  putative E3 ubiquitin-protein ligase UNKL isoform X7

    UniProtKB/TrEMBL
    B9EKD9
    Conserved Domains (2) summary
    cl17238
    Location:188 → 225
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    cl26597
    Location:77 → 138
    DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)

RNA

  1. XR_003952197.1 RNA Sequence

  2. XR_004939592.1 RNA Sequence

  3. XR_003952198.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5FWH2.2 GenPept UniProtKB/Swiss-Prot:Q5FWH2

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