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Stra6l STRA6-like [ Mus musculus (house mouse) ]

Gene ID: 74152, updated on 2-Nov-2024

Summary

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Official Symbol
Stra6lprovided by MGI
Official Full Name
STRA6-likeprovided by MGI
Primary source
MGI:MGI:1921402
See related
Ensembl:ENSMUSG00000028327 AllianceGenome:MGI:1921402
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rbpr2; 1300002K09Rik
Summary
Predicted to enable retinol transmembrane transporter activity and signaling receptor activity. Acts upstream of or within establishment of localization in cell; retinol transport; and vitamin A import into cell. Located in plasma membrane. Is expressed in Harderian gland; genitourinary system; gut; and liver. Orthologous to human STRA6LP (STRA6 like, pseudogene). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver adult (RPKM 35.2), liver E18 (RPKM 4.8) and 2 other tissues See more
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Genomic context

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See Stra6l in Genome Data Viewer
Location:
4 B1; 4 24.39 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (45818940..45887010)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (45824293..45887010)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10108 Neighboring gene STARR-seq mESC enhancer starr_10110 Neighboring gene predicted gene 12409 Neighboring gene aldehyde dehydrogenase 1 family, member B1 Neighboring gene insulin-like growth factor binding protein-like 1 Neighboring gene STARR-seq mESC enhancer starr_10113 Neighboring gene STARR-seq mESC enhancer starr_10114 Neighboring gene coiled-coil domain containing 180 Neighboring gene tudor domain containing 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mice Lacking the Systemic Vitamin A Receptor RBPR2 Show Decreased Ocular Retinoids and Loss of Visual Function. Radhakrishnan R, et al. Nutrients, 2022 Jun 8. PMID 35745101, Free PMC Article
  2. The STRA6 receptor is essential for retinol-binding protein-induced insulin resistance but not for maintaining vitamin A homeostasis in tissues other than the eye. Berry DC, et al. J Biol Chem, 2013 Aug 23. PMID 23839944, Free PMC Article
  3. Liver retinol transporter and receptor for serum retinol-binding protein (RBP4). Alapatt P, et al. J Biol Chem, 2013 Jan 11. PMID 23105095, Free PMC Article
  4. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mice Lacking the Systemic Vitamin A Receptor RBPR2 Show Decreased Ocular Retinoids and Loss of Visual Function.
    Title: Mice Lacking the Systemic Vitamin A Receptor RBPR2 Show Decreased Ocular Retinoids and Loss of Visual Function.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

General gene information

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Homology

Clone Names

  • MGC132877, MGC132878

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables retinol transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within retinol transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in vitamin A import into cell IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within vitamin A import into cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
stimulated by retinoic acid gene 6 protein-like
Names
RBP4 receptor 2
STRA6-like protein
retinol-binding protein 4 receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305421.1 → NP_001292350.1  stimulated by retinoic acid gene 6 protein-like isoform 2

    See identical proteins and their annotated locations for NP_001292350.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks an alternate exon in the 5' coding region, and uses a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AK004855, AK045033, AK050152, AL772381
    Consensus CDS
    CCDS80094.1
    UniProtKB/Swiss-Prot
    Q9DBN1
    Related
    ENSMUSP00000103411.2, ENSMUST00000107782.8
    Conserved Domains (1) summary
    pfam14752
    Location:1 → 511
    RBP_receptor; Retinol binding protein receptor

  2. NM_028788.4 → NP_083064.2  stimulated by retinoic acid gene 6 protein-like isoform 1

    See identical proteins and their annotated locations for NP_083064.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform.
    Source sequence(s)
    AK050152, AK050348, AL772381, BY776586
    Consensus CDS
    CCDS18141.1
    UniProtKB/Swiss-Prot
    B1AWX8, Q14DP6, Q14DS9, Q8C7I6, Q9DBN1
    Related
    ENSMUSP00000030011.6, ENSMUST00000030011.6
    Conserved Domains (1) summary
    pfam14752
    Location:14 → 602
    RBP_receptor; Retinol binding protein receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    45818940..45887010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538310.5 → XP_006538373.1  stimulated by retinoic acid gene 6 protein-like isoform X1

    See identical proteins and their annotated locations for XP_006538373.1

    Conserved Domains (1) summary
    pfam14752
    Location:93 → 681
    RBP_receptor; Retinol binding protein receptor

  2. XM_036164494.1 → XP_036020387.1  stimulated by retinoic acid gene 6 protein-like isoform X2

    UniProtKB/Swiss-Prot
    B1AWX8, Q14DP6, Q14DS9, Q8C7I6, Q9DBN1
    Conserved Domains (1) summary
    pfam14752
    Location:14 → 602
    RBP_receptor; Retinol binding protein receptor

  3. XM_006538312.2 → XP_006538375.1  stimulated by retinoic acid gene 6 protein-like isoform X2

    See identical proteins and their annotated locations for XP_006538375.1

    UniProtKB/Swiss-Prot
    B1AWX8, Q14DP6, Q14DS9, Q8C7I6, Q9DBN1
    Related
    ENSMUSP00000103412.2, ENSMUST00000107783.8
    Conserved Domains (1) summary
    pfam14752
    Location:14 → 602
    RBP_receptor; Retinol binding protein receptor

  4. XM_006538311.3 → XP_006538374.1  stimulated by retinoic acid gene 6 protein-like isoform X1

    See identical proteins and their annotated locations for XP_006538374.1

    Conserved Domains (1) summary
    pfam14752
    Location:93 → 681
    RBP_receptor; Retinol binding protein receptor

  5. XM_006538313.2 → XP_006538376.1  stimulated by retinoic acid gene 6 protein-like isoform X3

    See identical proteins and their annotated locations for XP_006538376.1

    UniProtKB/Swiss-Prot
    Q9DBN1
    Conserved Domains (1) summary
    pfam14752
    Location:1 → 511
    RBP_receptor; Retinol binding protein receptor

  6. XM_006538315.2 → XP_006538378.1  stimulated by retinoic acid gene 6 protein-like isoform X3

    See identical proteins and their annotated locations for XP_006538378.1

    UniProtKB/Swiss-Prot
    Q9DBN1
    Conserved Domains (1) summary
    pfam14752
    Location:1 → 511
    RBP_receptor; Retinol binding protein receptor

  7. XM_006538314.3 → XP_006538377.1  stimulated by retinoic acid gene 6 protein-like isoform X3

    See identical proteins and their annotated locations for XP_006538377.1

    UniProtKB/Swiss-Prot
    Q9DBN1
    Conserved Domains (1) summary
    pfam14752
    Location:1 → 511
    RBP_receptor; Retinol binding protein receptor

  8. XM_006538317.4 → XP_006538380.1  stimulated by retinoic acid gene 6 protein-like isoform X4

    Conserved Domains (1) summary
    pfam14752
    Location:1 → 410
    RBP_receptor; Retinol binding protein receptor
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DBN1.1 GenPept UniProtKB/Swiss-Prot:Q9DBN1

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