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F13a1 coagulation factor XIII, A1 subunit [ Mus musculus (house mouse) ]

Gene ID: 74145, updated on 2-Nov-2024

Summary

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Official Symbol
F13a1provided by MGI
Official Full Name
coagulation factor XIII, A1 subunitprovided by MGI
Primary source
MGI:MGI:1921395
See related
Ensembl:ENSMUSG00000039109 AllianceGenome:MGI:1921395
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
F13a; 1200014I03Rik
Summary
This gene encodes subunit A of the coagulation factor XIII that catalyzes the final step of the blood coagulation pathway. The encoded protein associates with subunit B to form a heterotetrameric proenzyme that undergoes thrombin-mediated proteolysis to generate active factor XIIIa. The transglutaminase activity of factor XIIIa is required for the calcium-dependent crosslinking of fibrin, leading to the formation of a clot. Mice lacking the encoded protein display impaired reproduction and reduced survival due to bleeding episodes, hematothorax, hematoperitoneum and subcutaneous hemorrhage. Additionally, mice lacking the encoded protein exhibit impaired wound healing and inadequate healing of myocardial infarction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Expression
Broad expression in bladder adult (RPKM 12.1), mammary gland adult (RPKM 11.7) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See F13a1 in Genome Data Viewer
Location:
13 A3.3; 13 14.44 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (37051150..37234220, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (36867178..37050244, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38636 Neighboring gene predicted gene, 30177 Neighboring gene neuritin 1 Neighboring gene STARR-seq mESC enhancer starr_34196 Neighboring gene predicted gene, 30489 Neighboring gene STARR-seq mESC enhancer starr_34198 Neighboring gene STARR-seq mESC enhancer starr_34199 Neighboring gene STARR-seq mESC enhancer starr_34200 Neighboring gene predicted gene, 30240 Neighboring gene STARR-seq mESC enhancer starr_34201 Neighboring gene predicted gene, 30549 Neighboring gene Rho GTPase activating protein 20 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Reciprocal stabilization of coagulation factor XIII-A and -B subunits is a determinant of plasma FXIII concentration.
    Title: Reciprocal stabilization of coagulation factor XIII-A and -B subunits is a determinant of plasma FXIII concentration.
  2. Mast cell-derived factor XIIIA contributes to sexual dimorphic defense against group B streptococcal infections.
    Title: Mast cell-derived factor XIIIA contributes to sexual dimorphic defense against group B streptococcal infections.
  3. Elimination of fibrin gamma-chain cross-linking by FXIIIa increases pulmonary embolism arising from murine inferior vena cava thrombi.
    Title: Elimination of fibrin γ-chain cross-linking by FXIIIa increases pulmonary embolism arising from murine inferior vena cava thrombi.
  4. Sustained depletion of FXIII-A by inducing acquired FXIII-B deficiency.
    Title: Sustained depletion of FXIII-A by inducing acquired FXIII-B deficiency.
  5. Assessment of expression and specific activities of transglutaminases TG1, TG2, and FXIII-A during osteoclastogenesis.
    Title: Assessment of expression and specific activities of transglutaminases TG1, TG2, and FXIII-A during osteoclastogenesis.
  6. Factor XIII-A and TG2 regulate resorption, adipogenesis and plasma fibronectin homeostasis in bone and bone marrow.
    Title: Transglutaminases factor XIII-A and TG2 regulate resorption, adipogenesis and plasma fibronectin homeostasis in bone and bone marrow.
  7. Suggest that resident macrophages maintain plasma FXIII-A and exclude the platelet lineage as a major contributor.
    Title: Cre/lox Studies Identify Resident Macrophages as the Major Source of Circulating Coagulation Factor XIII-A.
  8. These findings provide insight into assembly of the fibrinogen/FXIII-A2B2 complex in both physiologic and therapeutic situations.
    Title: The interaction between fibrinogen and zymogen FXIII-A2B2 is mediated by fibrinogen residues γ390-396 and the FXIII-B subunits.
  9. Mast cells have the ability to produce and degrade FXIIIA depending on their chymase expression profile: mast cells expressing chymase degrade FXIIIA, whereas mast cells that do not express chymase mainly produce FXIIIA
    Title: Proteome analysis of mast cell releasates reveals a role for chymase in the regulation of coagulation factor XIIIA levels via proteolytic degradation.
  10. A lack of factor XIII leads to prolonged clotting times, increased signs of inflammation, and elevated bacterial dissemination in streptococcal skin diseases.
    Title: Local activation of coagulation factor XIII reduces systemic complications and improves the survival of mice after Streptococcus pyogenes M1 skin infection.
Submit: New GeneRIF Correction See all GeneRIFs (35)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (6)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-glutamine gamma-glutamyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-glutamine gamma-glutamyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein-glutamine gamma-glutamyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-glutamine gamma-glutamyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blood coagulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in blood coagulation, fibrin clot formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in blood coagulation, fibrin clot formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in blood coagulation, fibrin clot formation ISO
Inferred from Sequence Orthology
more info
  
involved_in blood coagulation, fibrin clot formation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within peptide cross-linking IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptide cross-linking ISO
Inferred from Sequence Orthology
more info
  
involved_in peptide cross-linking ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
coagulation factor XIII A chain
Names
coagulation factor XIII, alpha subunit
coagulation factor XIIIa
protein-glutamine gamma-glutamyltransferase A chain
transglutaminase A chain
NP_001159863.1
NP_083060.2
XP_036014090.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166391.1 → NP_001159863.1  coagulation factor XIII A chain

    See identical proteins and their annotated locations for NP_001159863.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK030914, AK049092, AV249730, BM239113
    Consensus CDS
    CCDS26456.1
    UniProtKB/Swiss-Prot
    Q3TNF9, Q8BH61, Q8BIP2
    UniProtKB/TrEMBL
    Q3V3W7
    Related
    ENSMUSP00000128316.2, ENSMUST00000164727.8
    Conserved Domains (4) summary
    smart00460
    Location:309 → 400
    TGc; Transglutaminase/protease-like homologues
    COG1305
    Location:280 → 408
    YebA; Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones]
    pfam00868
    Location:47 → 164
    Transglut_N; Transglutaminase family
    pfam00927
    Location:519 → 623
    Transglut_C; Transglutaminase family, C-terminal ig like domain

  2. NM_028784.3 → NP_083060.2  coagulation factor XIII A chain

    See identical proteins and their annotated locations for NP_083060.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK049092, AV249730, BM239113
    Consensus CDS
    CCDS26456.1
    UniProtKB/Swiss-Prot
    Q3TNF9, Q8BH61, Q8BIP2
    UniProtKB/TrEMBL
    Q3V3W7
    Related
    ENSMUSP00000048667.9, ENSMUST00000037491.11
    Conserved Domains (4) summary
    smart00460
    Location:309 → 400
    TGc; Transglutaminase/protease-like homologues
    COG1305
    Location:280 → 408
    YebA; Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones]
    pfam00868
    Location:47 → 164
    Transglut_N; Transglutaminase family
    pfam00927
    Location:519 → 623
    Transglut_C; Transglutaminase family, C-terminal ig like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    37051150..37234220 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158197.1 → XP_036014090.1  coagulation factor XIII A chain isoform X1

    Conserved Domains (2) summary
    smart00460
    Location:67 → 158
    TGc; Transglutaminase/protease-like homologues
    pfam00927
    Location:277 → 381
    Transglut_C; Transglutaminase family, C-terminal ig like domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BH61.3 GenPept UniProtKB/Swiss-Prot:Q8BH61

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