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Nuak2 NUAK family, SNF1-like kinase, 2 [ Mus musculus (house mouse) ]

Gene ID: 74137, updated on 2-Nov-2024

Summary

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Official Symbol
Nuak2provided by MGI
Official Full Name
NUAK family, SNF1-like kinase, 2provided by MGI
Primary source
MGI:MGI:1921387
See related
Ensembl:ENSMUSG00000009772 AllianceGenome:MGI:1921387
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Snark; Omphk2; mKIAA0537; 1200013B22Rik
Summary
Predicted to enable ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including cellular response to glucose starvation; protein phosphorylation; and regulation of hippo signaling. Is expressed in several structures, including lung; neural ectoderm; nose; paravertebral ganglion; and ventricular layer. Human ortholog(s) of this gene implicated in anencephaly. Orthologous to human NUAK2 (NUAK family kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in large intestine adult (RPKM 25.5), small intestine adult (RPKM 23.1) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Nuak2 in Genome Data Viewer
Location:
1 E4; 1 57.24 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (132243827..132261233)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (132316125..132333488)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02247 Neighboring gene predicted gene, 38446 Neighboring gene predicted pseudogene 7241 Neighboring gene kelch domain containing 8A Neighboring gene STARR-positive B cell enhancer ABC_E2009 Neighboring gene STARR-seq mESC enhancer starr_02251 Neighboring gene predicted gene, 30744 Neighboring gene VISTA enhancer mm505 Neighboring gene RIKEN cDNA F730311O21 gene Neighboring gene STARR-positive B cell enhancer ABC_E7749 Neighboring gene STARR-positive B cell enhancer ABC_E11087 Neighboring gene transmembrane and coiled-coil domains 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Reduced sucrose nonfermenting AMPK-related kinase (SNARK) activity aggravates cancer-induced skeletal muscle wasting. Alves CRR, et al. Biomed Pharmacother, 2019 Sep. PMID 31387190, Free PMC Article
  2. Susceptibility of Snark-deficient mice to azoxymethane-induced colorectal tumorigenesis and the formation of aberrant crypt foci. Tsuchihara K, et al. Cancer Sci, 2008 Apr. PMID 18307533, Free PMC Article
  3. Sucrose nonfermenting AMPK-related kinase (SNARK) regulates exercise-stimulated and ischemia-stimulated glucose transport in the heart. Sun XL, et al. J Cell Biochem, 2019 Jan. PMID 30256437, Free PMC Article
  4. Provision of a voluntary exercise environment enhances running activity and prevents obesity in Snark-deficient mice. Ichinoseki-Sekine N, et al. Am J Physiol Endocrinol Metab, 2009 May. PMID 19276392
  5. The AMPK-related kinase SNARK regulates muscle mass and myocyte survival. Lessard SJ, et al. J Clin Invest, 2016 Feb. PMID 26690705, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GPR65 promotes intestinal mucosal Th1 and Th17 cell differentiation and gut inflammation through downregulating NUAK2.
    Title: GPR65 promotes intestinal mucosal Th1 and Th17 cell differentiation and gut inflammation through downregulating NUAK2.
  2. The MicroRNA miR-696 is regulated by SNARK and reduces mitochondrial activity in mouse skeletal muscle through Pgc1alpha inhibition.
    Title: The MicroRNA miR-696 is regulated by SNARK and reduces mitochondrial activity in mouse skeletal muscle through Pgc1α inhibition.
  3. NUAK2 and RCan2 participate in the p53 mutant pro-tumorigenic network.
    Title: NUAK2 and RCan2 participate in the p53 mutant pro-tumorigenic network.
  4. These results demonstrate that SNARK is highly expressed in the heart and HL1 cardiomyocytes, and that SNARK is phosphorylated in response to ischemia and exercise and functions in the regulation of cardiac glucose transport.
    Title: Sucrose nonfermenting AMPK-related kinase (SNARK) regulates exercise-stimulated and ischemia-stimulated glucose transport in the heart.
  5. A role for SNARK in the maintenance of skeletal muscle mass under cachexia conditions.
    Title: Reduced sucrose nonfermenting AMPK-related kinase (SNARK) activity aggravates cancer-induced skeletal muscle wasting.
  6. Using liver cancer as a model, NUAK2 was identified as an essential mediator of YAP-driven hepatomegaly and tumorigenesis in vivo.
    Title: NUAK2 is a critical YAP target in liver cancer.
  7. Data (including data from studies in knockout and transgenic mice) suggest that Nuak2/Snark is involved in both adipose inflammation and energy metabolism in white/brown adipocytes; Nuak2/Snark appears to regulate thermogenesis in brown adipocytes.
    Title: Sucrose Nonfermenting-Related Kinase Regulates Both Adipose Inflammation and Energy Homeostasis in Mice and Humans.
  8. These findings reveal a critical role for SNARK in myocyte survival and the maintenance of muscle mass with age.
    Title: The AMPK-related kinase SNARK regulates muscle mass and myocyte survival.
  9. NUAK1 and NUAK2 complementarily function in the apical constriction and apico-basal elongation that associate with the dorsolateral hinge point formation in cephalic neural plate during the 5- to 10-somite stages.
    Title: Neural tube defects by NUAK1 and NUAK2 double mutation.
  10. Data show that SNARK is activated by muscle contraction and is a unique mediator of contraction-stimulated glucose transport in skeletal muscle.
    Title: Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to glucose starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to glucose starvation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of hippo signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of hippo signaling ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
NUAK family SNF1-like kinase 2
Names
SNF1/AMP-activated protein kinase
omphalocele kinase 2
NP_001181954.1
NP_001403205.1
NP_083054.1
XP_006529972.1
XP_036009854.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195025.2 → NP_001181954.1  NUAK family SNF1-like kinase 2 isoform A

    See identical proteins and their annotated locations for NP_001181954.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (A) represents the longer transcript and encodes the longer isoform (A).
    Source sequence(s)
    AC160545
    Consensus CDS
    CCDS56642.1
    UniProtKB/Swiss-Prot
    Q80ZW3, Q8BZN4, Q8CIC0, Q9DBV0
    Related
    ENSMUSP00000072039.8, ENSMUST00000072177.14
    Conserved Domains (2) summary
    smart00220
    Location:57 → 315
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:53 → 315
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001416276.1 → NP_001403205.1  NUAK family SNF1-like kinase 2 isoform C

    Status: VALIDATED

    Source sequence(s)
    AC160545

  3. NM_028778.5 → NP_083054.1  NUAK family SNF1-like kinase 2 isoform B

    See identical proteins and their annotated locations for NP_083054.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (B) lacks an in-frame exon in the coding region, compared to variant A. This results in a shorter protein (isoform B), compared to isoform A.
    Source sequence(s)
    AC160545
    Consensus CDS
    CCDS15283.1
    UniProtKB/Swiss-Prot
    Q8BZN4
    Related
    ENSMUSP00000080769.6, ENSMUST00000082125.6
    Conserved Domains (2) summary
    smart00220
    Location:57 → 307
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14161
    Location:53 → 307
    STKc_NUAK2; Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    132243827..132261233
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153961.1 → XP_036009854.1  NUAK family SNF1-like kinase 2 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:1 → 208
    PKc_like; Protein Kinases, catalytic domain

  2. XM_006529909.3 → XP_006529972.1  NUAK family SNF1-like kinase 2 isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:1 → 56
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BZN4.2 GenPept UniProtKB/Swiss-Prot:Q8BZN4

Gene LinkOut

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