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Asz1 ankyrin repeat, SAM and basic leucine zipper domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 74068, updated on 14-Nov-2024

Summary

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Official Symbol
Asz1provided by MGI
Official Full Name
ankyrin repeat, SAM and basic leucine zipper domain containing 1provided by MGI
Primary source
MGI:MGI:1921318
See related
Ensembl:ENSMUSG00000010796 AllianceGenome:MGI:1921318
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gasz; ORF3; 4933400N19Rik
Summary
Involved in male meiotic nuclear division; retrotransposon silencing; and spermatogenesis. Located in pi-body. Is expressed in several structures, including central nervous system; genitourinary system; and limb mesenchyme. Orthologous to human ASZ1 (ankyrin repeat, SAM and basic leucine zipper domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in bladder adult (RPKM 3.4), testis adult (RPKM 3.0) and 1 other tissue See more
Orthologs
human all
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Genomic context

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See Asz1 in Genome Data Viewer
Location:
6 A2; 6 8.09 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (18050963..18109060, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (18050964..18109061, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene suppression of tumorigenicity 7 Neighboring gene STARR-seq mESC enhancer starr_15259 Neighboring gene STARR-positive B cell enhancer mm9_chr6:17726341-17726642 Neighboring gene predicted gene, 52895 Neighboring gene STARR-seq mESC enhancer starr_15260 Neighboring gene STARR-seq mESC enhancer starr_15261 Neighboring gene STARR-seq mESC enhancer starr_15263 Neighboring gene wingless-type MMTV integration site family, member 2 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene NSA2 ribosome biogenesis homolog pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Disruption of piRNA machinery by deletion of ASZ1/GASZ results in the expression of aberrant chimeric transcripts in gonocytes. Ikeda S, et al. J Reprod Dev, 2022 Apr 1. PMID 35095021, Free PMC Article
  2. GASZ and mitofusin-mediated mitochondrial functions are crucial for spermatogenesis. Zhang J, et al. EMBO Rep, 2016 Feb. PMID 26711429, Free PMC Article
  3. The nuage mediates retrotransposon silencing in mouse primordial ovarian follicles. Lim AK, et al. Development, 2013 Sep. PMID 23924633, Free PMC Article
  4. Identification of Gasz, an evolutionarily conserved gene expressed exclusively in germ cells and encoding a protein with four ankyrin repeats, a sterile-alpha motif, and a basic leucine zipper. Yan W, et al. Mol Endocrinol, 2002 Jun. PMID 12040005
  5. Mouse TEX14 is required for embryonic germ cell intercellular bridges but not female fertility. Greenbaum MP, et al. Biol Reprod, 2009 Mar. PMID 19020301, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Disruption of piRNA machinery by deletion of ASZ1/GASZ results in the expression of aberrant chimeric transcripts in gonocytes.
    Title: Disruption of piRNA machinery by deletion of ASZ1/GASZ results in the expression of aberrant chimeric transcripts in gonocytes.
  2. GASZ interacts with itself at the outer membrane of mitochondria and promotes mitofusion in a mitofusin/MFN-dependent manner. GASZ contains a functional mitochondrial targeting signal .
    Title: GASZ and mitofusin-mediated mitochondrial functions are crucial for spermatogenesis.
  3. Data reveal a potential role of GASZ during embryonic germ cell development and provide a powerful in vitro system for dissecting the molecular pathways in early germ cell formation during embryogenesis.
    Title: GASZ promotes germ cell derivation from embryonic stem cells.
  4. GASZ is essential for meiosis and suppression of retrotransposon expression in the male germ cells.
    Title: GASZ is essential for male meiosis and suppression of retrotransposon expression in the male germline.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in germ cell development NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in male meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulatory ncRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transposable element silencing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in pi-body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in pi-body IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1
Names
germ cell-specific ankyrin, SAM and basic leucine zipper domain containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023729.3 → NP_076218.3  ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1

    See identical proteins and their annotated locations for NP_076218.3

    Status: VALIDATED

    Source sequence(s)
    AF459789, BB020038, BC058859, BG088136
    Consensus CDS
    CCDS19929.1
    UniProtKB/Swiss-Prot
    G3X8S0, Q6PD92, Q8VD46, Q9JKQ7
    Related
    ENSMUSP00000010940.5, ENSMUST00000010940.11
    Conserved Domains (6) summary
    cd09521
    Location:273 → 333
    SAM_ASZ1; SAM domain of ASZ1 subfamily
    cd00204
    Location:77 → 202
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:83 → 179
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:47 → 99
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:168 → 222
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:151 → 179
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    18050963..18109060 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505176.3 → XP_006505239.1  ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006505239.1

    Conserved Domains (3) summary
    cd09521
    Location:124 → 184
    SAM_ASZ1; SAM domain of ASZ1 subfamily
    sd00045
    Location:2 → 30
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:4 → 85
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_006505178.3 → XP_006505241.1  ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006505241.1

    Conserved Domains (3) summary
    cd09521
    Location:124 → 184
    SAM_ASZ1; SAM domain of ASZ1 subfamily
    sd00045
    Location:2 → 30
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:4 → 85
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VD46.2 GenPept UniProtKB/Swiss-Prot:Q8VD46

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