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mutL DNA mismatch repair endonuclease MutL [ Halorubrum lacusprofundi ATCC 49239 ]

Gene ID: 7401764, updated on 22-Oct-2024

Summary

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Gene symbol
mutL
Gene description
DNA mismatch repair endonuclease MutL
Locus tag
HLAC_RS03120
Gene type
protein coding
Organism
Halorubrum lacusprofundi ATCC 49239 (strain: ATCC 49239, culture-collection: ATCC:49239, type-material: type strain of Halorubrum lacusprofundi)
Lineage
Archaea; Methanobacteriati; Methanobacteriota; Stenosarchaea group; Halobacteria; Halobacteriales; Haloferacaceae; Halorubrum
Old locus tag
Hlac_0629
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Genomic context

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Location:
chromosome: 1
Sequence:
Chromosome: 1; NC_012029.1 (646790..649093, complement)

Chromosome 1 - NC_012029.1Genomic Context describing neighboring genes Neighboring gene putative phosphothreonine lyase domain-containg protein Neighboring gene hypothetical protein Neighboring gene 3-ketoacyl-CoA thiolase Neighboring gene sugar ABC transporter permease Neighboring gene carbohydrate ABC transporter permease Neighboring gene extracellular solute-binding protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_012029.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. MutL traps MutS at a DNA mismatch. Qiu R, et al. Proc Natl Acad Sci U S A, 2015 Sep 1. PMID 26283381, Free PMC Article
  2. Extremophilic models for astrobiology: haloarchaeal survival strategies and pigments for remote sensing. DasSarma S, et al. Extremophiles, 2020 Jan. PMID 31463573, Free PMC Article
  3. An Antarctic Extreme Halophile and Its Polyextremophilic Enzyme: Effects of Perchlorate Salts. Laye VJ, et al. Astrobiology, 2018 Apr. PMID 29189043, Free PMC Article
  4. Key amino acid residues conferring enhanced enzyme activity at cold temperatures in an Antarctic polyextremophilic β-galactosidase. Laye VJ, et al. Proc Natl Acad Sci U S A, 2017 Nov 21. PMID 29109294, Free PMC Article
  5. Amino acid substitutions in cold-adapted proteins from Halorubrum lacusprofundi, an extremely halophilic microbe from antarctica. Dassarma S, et al. PLoS One, 2013. PMID 23536799, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General protein information

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Preferred Names
DNA mismatch repair endonuclease MutL

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_012029.1 Reference assembly

    Range
    646790..649093 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. WP_012659864.1 DNA mismatch repair endonuclease MutL [Halorubrum lacusprofundi]

    See identical proteins and their annotated locations for WP_012659864.1

    UniProtKB/TrEMBL
    B9LTU7
    Conserved Domains (5) summary
    pfam11714
    Location:470 → 542
    Inhibitor_I53; Thrombin inhibitor Madanin
    COG0323
    Location:4 → 757
    MutL; DNA mismatch repair ATPase MutL [Replication, recombination and repair]
    cd00075
    Location:26 → 130
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
    pfam01119
    Location:214 → 322
    DNA_mis_repair; DNA mismatch repair protein, C-terminal domain
    pfam08676
    Location:571 → 714
    MutL_C; MutL C terminal dimerization domain
Nucleotide Protein
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