abcg2a ATP-binding cassette, sub-family G (WHITE), member 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: abcg2aprovided by ZNC
Official Full Name: ATP-binding cassette, sub-family G (WHITE), member 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050517-35
See related: Ensembl:ENSDARG00000100075 AllianceGenome:ZFIN:ZDB-GENE-050517-35
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fd59c01; wu:fd59c01
Summary: Predicted to enable ATPase-coupled transmembrane transporter activity; efflux transmembrane transporter activity; and riboflavin transmembrane transporter activity. Predicted to be involved in transmembrane transport. Part of ATP-binding activity cassette (ABC) transporter complex. Is expressed in hematopoietic stem cell; intestine; and kidney. Human ortholog(s) of this gene implicated in gout; hematologic cancer (multiple); renal cell carcinoma; and toxic encephalopathy. Orthologous to human ABCG2 (ATP binding cassette subfamily G member 2 (JR blood group)). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 23

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (45910018..45936777)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (46065242..46091925)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Abcg2a is the functional homolog of human ABCG2 expressed at the zebrafish blood-brain barrier.
Title: Abcg2a is the functional homolog of human ABCG2 expressed at the zebrafish blood-brain barrier.

Submit: New GeneRIF Correction

General gene information

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Markers

AI497110 (e-PCR)
- UniSTS:206368

fb60c04.y1 (e-PCR)
- UniSTS:190849

fd59c01.x1 (e-PCR)
- UniSTS:195748

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables efflux transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables riboflavin transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of ATP-binding cassette (ABC) transporter complex	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: broad substrate specificity ATP-binding cassette transporter ABCG2

Names: ATP-binding cassette transporter sub-family G member 2a

NP_001036240.1

EC 7.6.2.2

XP_021325521.1

EC 7.6.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001042775.1 → NP_001036240.1 broad substrate specificity ATP-binding cassette transporter ABCG2

See identical proteins and their annotated locations for NP_001036240.1

Status: PROVISIONAL

Source sequence(s)

DQ223858

UniProtKB/TrEMBL

Q2Q447

Related

ENSDARP00000140421.2, ENSDART00000165025.2

Conserved Domains (3) summary

cd03213
Location:30 → 263

ABCG_EPDR; Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily

TIGR00955
Location:43 → 637

3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein

pfam01061
Location:373 → 577

ABC2_membrane; ABC-2 type transporter

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007134.7 Reference GRCz11 Primary Assembly

Range

45910018..45936777

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021469846.2 → XP_021325521.1 broad substrate specificity ATP-binding cassette transporter ABCG2 isoform X1

UniProtKB/TrEMBL

A0A8M9PT70

Conserved Domains (1) summary

cl28180
Location:43 → 638

PRK10535; macrolide transporter ATP-binding /permease protein; Provisional