cadm1.L cell adhesion molecule 1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: cadm1.L
Official Full Name: cell adhesion molecule 1 L homeolog
Primary source: Xenbase:XB-GENE-6254081
Locus tag: XELAEV_18035475mg
See related: EnsemblRapid:ENSXLAG00005012421 AllianceGenome:Xenbase:XB-GENE-6254081
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: bl2; st17; cadm1; igsf4; necl2; ra175; tslc1; igsf4a; necl-2; sgigsf; syncam; xnecl2; stslc-1; syncam1
Summary: Predicted to enable signaling receptor binding activity. Predicted to act upstream of or within cell recognition; detection of stimulus; and susceptibility to natural killer cell mediated cytotoxicity. Predicted to be located in neuron projection; plasma membrane; and synapse. Human ortholog(s) of this gene implicated in breast carcinoma and prostate cancer. Orthologous to human CADM1 (cell adhesion molecule 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 7L

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	7L	NC_054383.1 (84773943..84900376)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	7L	NC_030736.1 (76184746..76311292)

Chromosome 7L - NC_054383.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell recognition	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within detection of stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within susceptibility to natural killer cell mediated cytotoxicity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cell adhesion molecule 1 L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001096683.1 → NP_001090152.1 cell adhesion molecule 1 L homeolog precursor

See identical proteins and their annotated locations for NP_001090152.1

Status: PROVISIONAL

Source sequence(s)

BC108832

UniProtKB/TrEMBL

A0A974CH37, Q5FWW6

Related

ENSXLAP00005036463.1, ENSXLAT00005037372.1

Conserved Domains (4) summary

cd05881
Location:30 → 124

Ig1_Necl-2; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1))

cd05883
Location:145 → 227

Ig2_Necl-2; Second immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1))

smart00408
Location:243 → 304

IGc2; Immunoglobulin C-2 Type

smart00410
Location:34 → 124

IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054383.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

84773943..84900376

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_018224647.2 → XP_018080136.1 cell adhesion molecule 1 L homeolog isoform X1

UniProtKB/TrEMBL

A0A1L8FLM5, A0A974CFK6, A0A974CH37

Related

ENSXLAP00005036451.1, ENSXLAT00005037360.1
XM_018224648.2 → XP_018080137.1 cell adhesion molecule 1 L homeolog isoform X2

UniProtKB/TrEMBL

A0A8J0T8P9, A0A974CH37

Related

ENSXLAP00005036454.1, ENSXLAT00005037363.1
XM_041568597.1 → XP_041424531.1 cell adhesion molecule 1 L homeolog isoform X3

UniProtKB/TrEMBL

A0A8J1L4Q4, A0A974CH37

Related

ENSXLAP00005036467.1, ENSXLAT00005037376.1

Conserved Domains (4) summary

smart00294
Location:384 → 402

4.1m; putative band 4.1 homologues' binding motif

smart00408
Location:266 → 327

IGc2; Immunoglobulin C-2 Type

cd00096
Location:67 → 71

Ig; Ig strand B [structural motif]

cl11960
Location:55 → 147

Ig; Immunoglobulin domain
XM_018224649.2 → XP_018080138.1 cell adhesion molecule 1 L homeolog isoform X4

UniProtKB/TrEMBL

A0A8J0T8S6, A0A974CH37

Related

ENSXLAP00005036472.1, ENSXLAT00005037381.1