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Pebp4 phosphatidylethanolamine binding protein 4 [ Mus musculus (house mouse) ]

Gene ID: 73523, updated on 2-Nov-2024

Summary

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Official Symbol
Pebp4provided by MGI
Official Full Name
phosphatidylethanolamine binding protein 4provided by MGI
Primary source
MGI:MGI:1920773
See related
Ensembl:ENSMUSG00000022085 AllianceGenome:MGI:1920773
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PEBP-4
Summary
Predicted to be located in extracellular region. Is expressed in bone and rib. Orthologous to human PEBP4 (phosphatidylethanolamine binding protein 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 89.7) See more
Orthologs
human all
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Genomic context

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See Pebp4 in Genome Data Viewer
Location:
14 D2; 14 36.1 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (70077856..70297367)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (69840407..70059918)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37064 Neighboring gene tumor necrosis factor receptor superfamily, member 10b Neighboring gene STARR-positive B cell enhancer ABC_E10832 Neighboring gene STARR-positive B cell enhancer ABC_E7329 Neighboring gene Rho-related BTB domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E5452 Neighboring gene STARR-seq mESC enhancer starr_37068 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:70261408-70261517 Neighboring gene STARR-positive B cell enhancer ABC_E9049 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_37070 Neighboring gene ribosomal protein S11 pseudogene Neighboring gene STARR-seq mESC enhancer starr_37071 Neighboring gene predicted gene, 41198 Neighboring gene predicted gene, 33524 Neighboring gene STARR-seq mESC enhancer starr_37072 Neighboring gene STARR-positive B cell enhancer mm9_chr14:70468715-70469016 Neighboring gene STARR-positive B cell enhancer mm9_chr14:70469146-70469446 Neighboring gene STARR-positive B cell enhancer ABC_E8569 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:70499772-70499955 Neighboring gene early growth response 3 Neighboring gene bridging integrator 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Phosphatidylethanolamine-binding protein 4 deficiency exacerbates carbon tetrachloride-induced liver fibrosis by regulating the NF-κB signaling pathway. Luo Q, et al. Front Pharmacol, 2022. PMID 36120358, Free PMC Article
  2. Hepatocyte-Conditional Knockout of Phosphatidylethanolamine Binding Protein 4 Aggravated LPS/D-GalN-Induced Acute Liver Injury via the TLR4/NF-κB Pathway. Qu XQ, et al. Front Immunol, 2022. PMID 35874667, Free PMC Article
  3. Promotion of cellular migration and apoptosis resistance by a mouse eye-specific phosphatidylethanolamine-binding protein. Zhang Y, et al. Int J Mol Med, 2007 Jan. PMID 17143548
  4. PEBP4 deficiency aggravates LPS-induced acute lung injury and alveolar fluid clearance impairment via modulating PI3K/AKT signaling pathway. Shi QQ, et al. Cell Mol Life Sci, 2024 Mar 13. PMID 38472560, Free PMC Article
  5. Phosphatidylethanolamine binding protein 4 (PEBP4) is a secreted protein and has multiple functions. He H, et al. Biochim Biophys Acta, 2016 Jul. PMID 27033522, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PEBP4 deficiency aggravates LPS-induced acute lung injury and alveolar fluid clearance impairment via modulating PI3K/AKT signaling pathway.
    Title: PEBP4 deficiency aggravates LPS-induced acute lung injury and alveolar fluid clearance impairment via modulating PI3K/AKT signaling pathway.
  2. Hepatocyte-Conditional Knockout of Phosphatidylethanolamine Binding Protein 4 Aggravated LPS/D-GalN-Induced Acute Liver Injury via the TLR4/NF-kappaB Pathway.
    Title: Hepatocyte-Conditional Knockout of Phosphatidylethanolamine Binding Protein 4 Aggravated LPS/D-GalN-Induced Acute Liver Injury via the TLR4/NF-κB Pathway.
  3. PEBP4 is a secreted protein and has multiple functions, including a role in Akt phosphorylation.
    Title: Phosphatidylethanolamine binding protein 4 (PEBP4) is a secreted protein and has multiple functions.
  4. We describe the cloning and functional characterization of the mouse homolog of hPEBP4 (mPEBP4). We demonstrate that mPEBP4 promotes cellular migration and invasion by inhibiting ERK1/2 and JNK activation and up-regulating the expression of COX-2.
    Title: Promotion of cellular migration and apoptosis resistance by a mouse eye-specific phosphatidylethanolamine-binding protein.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1)  1 citation
  • Targeted (2) 

General gene information

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Markers

Homology

Clone Names

  • 1700051A02Rik, 1700081D17Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphatidylethanolamine-binding protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028526.4 → NP_082802.1  phosphatidylethanolamine-binding protein 4 isoform b precursor

    See identical proteins and their annotated locations for NP_082802.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons, and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK006750, BC048621
    UniProtKB/TrEMBL
    Q9D9L9

  2. NM_028560.4 → NP_082836.2  phosphatidylethanolamine-binding protein 4 isoform a precursor

    See identical proteins and their annotated locations for NP_082836.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC123867, AK006750, CF104379
    Consensus CDS
    CCDS27245.1
    UniProtKB/Swiss-Prot
    G3X8V3, Q9D9G2
    Related
    ENSMUSP00000022678.4, ENSMUST00000022678.5
    Conserved Domains (1) summary
    cd00866
    Location:95 → 219
    PEBP_euk; PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    70077856..70297367
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D9G2.2 GenPept UniProtKB/Swiss-Prot:Q9D9G2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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