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plcd4.L phospholipase C delta 4 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 735225, updated on 4-Nov-2024

Summary

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Official Symbol
plcd4.L
Official Full Name
phospholipase C delta 4 L homeolog
Primary source
Xenbase:XB-GENE-965139
Locus tag
XELAEV_18044519mg
See related
EnsemblRapid:ENSXLAG00005028156 AllianceGenome:Xenbase:XB-GENE-965139
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
plcd4
Summary
Predicted to enable calcium ion binding activity and phosphatidylinositol phospholipase C activity. Predicted to act upstream of or within lipid catabolic process; phosphatidylinositol-mediated signaling; and release of sequestered calcium ion into cytosol. Predicted to be located in endoplasmic reticulum; membrane; and nucleus. Orthologous to human PLCD4 (phospholipase C delta 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See plcd4.L in Genome Data Viewer
Location:
chromosome: 9_10L
Exon count:
21
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 9_10L NC_054387.1 (63299011..63326689, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 9_10L NC_030740.1 (52771421..52785518, complement)

Chromosome 9_10L - NC_054387.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121398284 Neighboring gene uncharacterized LOC121398283 Neighboring gene cytochrome P450, family 27, subfamily A, polypeptide 1 Neighboring gene BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone L homeolog Neighboring gene zinc finger protein 142 L homeolog Neighboring gene CCR4-NOT transcription complex subunit 9L homeolog Neighboring gene ubiquitin specific peptidase 37 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC131193

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within release of sequestered calcium ion into cytosol IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
Names
PLC-delta-4
phosphoinositide phospholipase C delta-4
phospholipase C-delta-4
NP_001090146.1
XP_041431701.1
XP_041431702.1
XP_041431703.1
XP_041431704.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001096677.1 → NP_001090146.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4

    See identical proteins and their annotated locations for NP_001090146.1

    Status: PROVISIONAL

    Source sequence(s)
    BC108618
    UniProtKB/Swiss-Prot
    Q32NH8
    UniProtKB/TrEMBL
    A0A1L8EVR6, A0A974H3F7
    Related
    ENSXLAP00005083881.1, ENSXLAT00005085519.1
    Conserved Domains (4) summary
    cd00275
    Location:621 → 749
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08631
    Location:289 → 589
    PI-PLCc_delta4; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta4
    cd13363
    Location:18 → 133
    PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
    cd16219
    Location:138 → 277
    EFh_PI-PLCdelta4; EF-hand motif found in phosphoinositide phospholipase C delta 4 (PI-PLC-delta4)

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054387.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    63299011..63326689 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041575769.1 → XP_041431703.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1

    UniProtKB/Swiss-Prot
    Q32NH8
    UniProtKB/TrEMBL
    A0A1L8EVR6, A0A974H3F7
    Conserved Domains (4) summary
    cd00275
    Location:621 → 749
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08631
    Location:289 → 589
    PI-PLCc_delta4; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta4
    cd13363
    Location:18 → 133
    PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
    cd16219
    Location:138 → 277
    EFh_PI-PLCdelta4; EF-hand motif found in phosphoinositide phospholipase C delta 4 (PI-PLC-delta4)

  2. XM_041575768.1 → XP_041431702.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1

    UniProtKB/Swiss-Prot
    Q32NH8
    UniProtKB/TrEMBL
    A0A1L8EVR6, A0A974H3F7
    Conserved Domains (4) summary
    cd00275
    Location:621 → 749
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08631
    Location:289 → 589
    PI-PLCc_delta4; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta4
    cd13363
    Location:18 → 133
    PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
    cd16219
    Location:138 → 277
    EFh_PI-PLCdelta4; EF-hand motif found in phosphoinositide phospholipase C delta 4 (PI-PLC-delta4)

  3. XM_041575767.1 → XP_041431701.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1

    UniProtKB/Swiss-Prot
    Q32NH8
    UniProtKB/TrEMBL
    A0A1L8EVR6, A0A974H3F7
    Conserved Domains (4) summary
    cd00275
    Location:621 → 749
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08631
    Location:289 → 589
    PI-PLCc_delta4; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta4
    cd13363
    Location:18 → 133
    PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
    cd16219
    Location:138 → 277
    EFh_PI-PLCdelta4; EF-hand motif found in phosphoinositide phospholipase C delta 4 (PI-PLC-delta4)

  4. XM_041575770.1 → XP_041431704.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1

    UniProtKB/Swiss-Prot
    Q32NH8
    UniProtKB/TrEMBL
    A0A1L8EVR6, A0A974H3F7
    Conserved Domains (4) summary
    cd00275
    Location:621 → 749
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08631
    Location:289 → 589
    PI-PLCc_delta4; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta4
    cd13363
    Location:18 → 133
    PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
    cd16219
    Location:138 → 277
    EFh_PI-PLCdelta4; EF-hand motif found in phosphoinositide phospholipase C delta 4 (PI-PLC-delta4)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q32NH8.1 GenPept UniProtKB/Swiss-Prot:Q32NH8

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