mkrn2.L makorin ring finger protein 2 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: mkrn2.L
Official Full Name: makorin ring finger protein 2 L homeolog
Primary source: Xenbase:XB-GENE-6079172
Locus tag: XELAEV_18001869mg
See related: EnsemblRapid:ENSXLAG00005006273 AllianceGenome:Xenbase:XB-GENE-6079172
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: mkrn2; rnf62
Summary: Predicted to enable metal ion binding activity and ubiquitin protein ligase activity. Predicted to act upstream of or within cell differentiation and protein polyubiquitination. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 4L

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	4L	NC_054377.1 (154646873..154653645, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	Unplaced Scaffold	NW_016694815.1 (4565550..4573615, complement)

Chromosome 4L - NC_054377.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results collectively suggest that the third C(3)H zinc finger, Cys-His motif and C(3)HC(4) RING zinc finger are indispensable for the anti-neurogenic activity of mkrn2.
Title: Identification of protein domains required for makorin-2-mediated neurogenesis inhibition in Xenopus embryos.
mkrn2 acts downstream of PI3K and Akt and upstream of GSK-3beta
Title: Makorin-2 is a neurogenesis inhibitor downstream of phosphatidylinositol 3-kinase/Akt (PI3K/Akt) signal.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein polyubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase makorin-2

Names: RING-type E3 ubiquitin transferase makorin-2; makorin-2; probable E3 ubiquitin-protein ligase makorin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001096637.2 → NP_001090106.2 E3 ubiquitin-protein ligase makorin-2

Status: VALIDATED

Source sequence(s)

JAGEVR010000047

Related

ENSXLAP00005018663.1, ENSXLAT00005018998.1

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054377.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

154646873..154653645 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)