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tpte2.L transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 735146, updated on 4-Nov-2024

Summary

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Official Symbol
tpte2.L
Official Full Name
transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 L homeolog
Primary source
Xenbase:XB-GENE-1015887
Locus tag
XELAEV_18013678mg
See related
EnsemblRapid:ENSXLAG00005034659 AllianceGenome:Xenbase:XB-GENE-1015887
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
tpte2
Summary
Predicted to enable monoatomic ion channel activity; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; and protein tyrosine phosphatase activity. Predicted to act upstream of or within several processes, including dephosphorylation; negative regulation of cell population proliferation; and regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be located in several cellular components, including cytosol; nucleus; and plasma membrane. Orthologous to human TPTE2 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tpte2.L in Genome Data Viewer
Location:
chromosome: 2L
Exon count:
21
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 2L NC_054373.1 (158773991..158809135)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 2L NC_030726.1 (152875627..152905921)

Chromosome 2L - NC_054373.1Genomic Context describing neighboring genes Neighboring gene vacuolar protein sorting 36 homolog L homeolog Neighboring gene thrombospondin type 1 domain containing 1 L homeolog Neighboring gene fibrinogen like 1B L homeolog Neighboring gene solute carrier family 25 member 15, gene 2 L homeolog Neighboring gene mitochondrial ornithine transporter 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC115740

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell motility IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphatidylinositol dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001096603.1 → NP_001090072.1  transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 L homeolog

    See identical proteins and their annotated locations for NP_001090072.1

    Status: PROVISIONAL

    Source sequence(s)
    BC099069
    UniProtKB/TrEMBL
    F6LWC2, Q4KLP3
    Related
    ENSXLAP00005103948.1, ENSXLAT00005105967.1
    Conserved Domains (4) summary
    smart00404
    Location:269 → 363
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    pfam00520
    Location:76 → 174
    Ion_trans; Ion transport protein
    pfam10409
    Location:372 → 509
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein
    cl19167
    Location:81 → 141
    Bac_export_2; FlhB HrpN YscU SpaS Family

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054373.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    158773991..158809135
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041581128.1 → XP_041437062.1  transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 L homeolog isoform X2

    UniProtKB/TrEMBL
    A0A1L8HIT6, A0A974HZV1, F6LWC2
    Related
    ENSXLAP00005104050.1, ENSXLAT00005106069.1
    Conserved Domains (3) summary
    cd14510
    Location:187 → 363
    PTP_VSP_TPTE; protein tyrosine phosphatase-like catalytic domain of voltage-sensitive phosphatase/transmembrane phosphatase with tensin homology
    pfam00520
    Location:54 → 174
    Ion_trans; Ion transport protein
    pfam10409
    Location:372 → 509
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein

  2. XM_018245357.1 → XP_018100846.1  transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J0UBD8, F6LWC2
    Related
    ENSXLAP00005103998.1, ENSXLAT00005106017.1
Nucleotide Protein Strain
Heading Accession and Version

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