cenpa.L centromere protein A L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: cenpa.L
Official Full Name: centromere protein A L homeolog
Primary source: Xenbase:XB-GENE-865062
Locus tag: XELAEV_18039158mg
See related: EnsemblRapid:ENSXLAG00005024440
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: cenpa; 2p23.3
Annotation information: Annotation category: partial on reference assembly
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Genomic context

Location:: chromosome: 8L

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	8L	NC_054385.1 (65251553..65256528)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	8L	NC_030738.1 (51754277..51759252)

Chromosome 8L - NC_054385.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Repression of CENP-A assembly in metaphase requires HJURP phosphorylation and inhibition by M18BP1.
Title: Repression of CENP-A assembly in metaphase requires HJURP phosphorylation and inhibition by M18BP1.
CENP-C and M18BP1 recruit HJURP to centromeres for new CENP-A assembly.
Title: Xenopus laevis M18BP1 Directly Binds Existing CENP-A Nucleosomes to Promote Centromeric Chromatin Assembly.
CENP-A assembly into chromatin requires unidentified deoxycytidine deaminase and UNG2, a uracil DNA glycosylase.
Title: Xenopus CENP-A assembly into chromatin requires base excision repair proteins.
CENP-A deposition at the centromeres is dependent on HJURP.
Title: Xenopus HJURP and condensin II are required for CENP-A assembly.
XCENP-A associates with frog centromeric repeat 1.
Title: Identification of xenopus CENP-A and an associated centromeric DNA repeat.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables structural constituent of chromatin	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
part_of nucleosome	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: histone H3-like centromeric protein A

Names: CENP-A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.