fmr1.S fragile X messenger ribonucleoprotein 1 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: fmr1.S
Official Full Name: fragile X messenger ribonucleoprotein 1 S homeolog
Primary source: Xenbase:XB-GENE-977118
Locus tag: XELAEV_18042175mg
See related: EnsemblRapid:ENSXLAG00005014388 AllianceGenome:Xenbase:XB-GENE-977118
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: fmr1; fmrp; fmr-1; fmr1-a; fmr1-b
Summary: Predicted to enable several functions, including N6-methyladenosine-containing RNA reader activity; RNA binding activity; and protein dimerization activity. Predicted to act upstream of or within with a positive effect on miRNA-mediated post-transcriptional gene silencing. Predicted to act upstream of or within several processes, including modulation of chemical synaptic transmission; positive regulation of cellular component organization; and regulation of gene expression. Predicted to be located in several cellular components, including filopodium; nuclear lumen; and perikaryon. Predicted to be part of SMN complex. Predicted to be active in cytoplasmic stress granule and neuronal ribonucleoprotein granule. Human ortholog(s) of this gene implicated in fragile X syndrome; fragile X-associated tremor/ataxia syndrome; and primary ovarian insufficiency 1. Orthologous to human FMR1 (fragile X messenger ribonucleoprotein 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 8S

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	8S	NC_054386.1 (65308762..65345151)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	8S	NC_030739.1 (63018508..63054797)

Chromosome 8S - NC_054386.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data provide the first lines of evidence that FMRP binds mRNA in the nucleus.
Title: Fragile X mental retardation protein FMRP binds mRNAs in the nucleus.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables G-quadruplex RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables N6-methyladenosine-containing RNA reader activity	ISS Inferred from Sequence or Structural Similarity more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA stem-loop binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA strand annealing activity	ISS Inferred from Sequence or Structural Similarity more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables dynein complex binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA 3'-UTR binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA 5'-UTR binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables methylated histone binding	ISS Inferred from Sequence or Structural Similarity more info
enables miRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info
enables molecular condensate scaffold activity	ISS Inferred from Sequence or Structural Similarity more info
enables poly(G) binding	ISS Inferred from Sequence or Structural Similarity more info
enables poly(U) RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables sequence-specific mRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables siRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables translation regulator activity	IEA Inferred from Electronic Annotation more info
enables translation repressor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA repair	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within RNA splicing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glutamate receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mRNA export from nucleus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within_positive_effect miRNA-mediated post-transcriptional gene silencing	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of cytoplasmic translation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of long-term synaptic depression	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of miRNA-mediated gene silencing	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of synaptic vesicle exocytosis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of translation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of translational initiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of voltage-gated calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within non-membrane-bounded organelle assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of dendritic spine development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of filopodium assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of miRNA-mediated gene silencing	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of proteasomal protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of receptor internalization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of translation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of alternative mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of alternative mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of dendritic spine development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of filopodium assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of filopodium assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of mRNA stability	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of mRNA stability	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of neuronal action potential	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of neurotransmitter secretion	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal muscle organ development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within stress granule assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of SMN complex	ISS Inferred from Sequence or Structural Similarity more info
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon	ISS Inferred from Sequence or Structural Similarity more info
located_in axon terminus	ISS Inferred from Sequence or Structural Similarity more info
located_in cell projection	ISS Inferred from Sequence or Structural Similarity more info
located_in chromocenter	ISS Inferred from Sequence or Structural Similarity more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome	ISS Inferred from Sequence or Structural Similarity more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic ribonucleoprotein granule	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic ribonucleoprotein granule	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic stress granule	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasmic stress granule	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
located_in dendritic filopodium	IEA Inferred from Electronic Annotation more info
located_in dendritic filopodium	ISS Inferred from Sequence or Structural Similarity more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in dendritic spine	ISS Inferred from Sequence or Structural Similarity more info
located_in dendritic spine neck	IEA Inferred from Electronic Annotation more info
located_in filopodium tip	IEA Inferred from Electronic Annotation more info
located_in filopodium tip	ISS Inferred from Sequence or Structural Similarity more info
located_in glial cell projection	ISS Inferred from Sequence or Structural Similarity more info
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in growth cone	ISS Inferred from Sequence or Structural Similarity more info
located_in growth cone filopodium	ISS Inferred from Sequence or Structural Similarity more info
is_active_in intracellular non-membrane-bounded organelle	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in neuron projection	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
is_active_in neuronal ribonucleoprotein granule	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal ribonucleoprotein granule	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in perikaryon	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in postsynapse	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in presynapse	IEA Inferred from Electronic Annotation more info
located_in presynapse	ISS Inferred from Sequence or Structural Similarity more info
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synapse	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: fragile X messenger ribonucleoprotein 1 homolog B

Names: FMRP translational regulator 1 S homeolog; FMRP-B; protein FMR-1-B; synaptic functional regulator FMR1; xFMR1-B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001096495.1 → NP_001089964.1 fragile X messenger ribonucleoprotein 1 homolog B

See identical proteins and their annotated locations for NP_001089964.1

Status: PROVISIONAL

Source sequence(s)

BC112952

UniProtKB/Swiss-Prot

Q2KHP9

UniProtKB/TrEMBL

A0A974C3K8, A0A974H7P1, B7ZRL0

Related

ENSXLAP00005042157.1, ENSXLAT00005043223.1

Conserved Domains (4) summary

smart00322
Location:221 → 280

KH; K homology RNA-binding domain

pfam00013
Location:283 → 351

KH_1; KH domain

pfam12235
Location:354 → 454

FXMRP1_C_core; Fragile X-related 1 protein core C terminal

pfam16098
Location:482 → 564

FXMR_C2; Fragile X-related mental retardation protein C-terminal region 2