UCN urocortin [Homo sapiens (human)] - Gene

Summary

Official Symbol: UCNprovided by HGNC
Official Full Name: urocortinprovided by HGNC
Primary source: HGNC:HGNC:12516
See related: Ensembl:ENSG00000163794 MIM:600945; AllianceGenome:HGNC:12516
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: UI; UCN1; UROC
Summary: This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family. The encoded preproprotein is proteolytically processed to generate the mature peptide, an endogenous ligand for both corticotropin-releasing factor receptor 1 and corticotropin-releasing factor receptor 2. In the brain this peptide may be responsible for the effects of stress on appetite. This peptide may also play a role in mood disorders, neurodegeneration, and skeletal system disorders. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin-2. [provided by RefSeq, Feb 2016]
Expression: Low expression observed in reference dataset See more
Orthologs: mouse all
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Genomic context

Location:: 2p23.3

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (27307400..27308445, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (27349815..27350860, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (27530268..27531313, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Urocortin Neuropeptide Levels Are Impaired in the PBMCs of Overweight Children.
Title: Urocortin Neuropeptide Levels Are Impaired in the PBMCs of Overweight Children.
Identification of a four immune-related genes signature based on an immunogenomic landscape analysis of clear cell renal cell carcinoma.
Title: Identification of a four immune-related genes signature based on an immunogenomic landscape analysis of clear cell renal cell carcinoma.
Data report that Ucn1 is expressed in human articular chondrocytes (AC) and confirm that Ucn1 is essential for the survival of AC cells in the absence of pro-apoptotic stimuli.
Title: Chondroprotection by urocortin involves blockade of the mechanosensitive ion channel Piezo1.
REVIEW: Cardioprotective Utility of Urocortin in Myocardial Ischemia- Reperfusion Injury: Where do We Stand?
Title: Cardioprotective Utility of Urocortin in Myocardial Ischemia- Reperfusion Injury: Where do We Stand?
In women with chronic pelvic pain, infertility, or both symptoms, the probability of endometriosis (positive predictive value) increased consistently with the increase of plasma Ucn1 levels.
Title: Plasma urocortin-1 as a preoperative marker of endometriosis in symptomatic women.
Study found reduced miR-326 levels concomitant with elevated Ucn1 levels in Edinger-Westphal nucleus (EWcp) of depressed suicide completers and in the EWcp of depressed rats. In fully recovered rats, both serum and EWcp miR-326 levels rebounded to nonstressed levels. While downregulation of miR-326 levels in primary midbrain neurons enhanced Ucn1 expression levels, miR-326 overexpression selectively reduced its levels.
Title: MicroRNA-326 acts as a molecular switch in the regulation of midbrain urocortin 1 expression.
In deep infiltrating endometriotic lesions, CRH, Ucn and CRH-R2 mRNA levels were significantly higher than in ovarian endometrioma.
Title: Urocortin and corticotrophin-releasing hormone receptor type 2 mRNA are highly expressed in deep infiltrating endometriotic lesions.
UCN I is secreted from human glioblastoma cells by exocytosis through constitutive secretory granules.
Title: Secretion of urocortin I by human glioblastoma cell lines, possibly via the constitutive pathway.
Findings identify Ucn as a potential mediator that inhibits TGFbeta1 oncogenic signaling in breast neoplasm.
Title: Urocortin attenuates TGFβ1-induced Snail1 and slug expressions: inhibitory role of Smad7 in Smad2/3 signaling in breast cancer cells.
In women with adnexal endometrioma versus teratoma, the medians were 105.31 pg/mL versus 120.84 pg/mL for urocortin, 7.16 pg/mL versus 9.13 pg/mL for leptin and 584.33 pg/mL versus 657.82 pg/mL for ghrelin (p > 0.05), respectively.
Title: Novel markers in the diagnostics of endometriomas: Urocortin, ghrelin, and leptin or leukocytes, fibrinogen, and CA-125?

Submit: New GeneRIF Correction See all GeneRIFs (55)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G19419 (e-PCR)
- UniSTS:46666

RH103047 (e-PCR)
- UniSTS:97381

NoName (e-PCR)
- UniSTS:482408

STS-X76538 (e-PCR)
- UniSTS:8310

RH70909 (e-PCR)
- UniSTS:3196

RNF30_1941 (e-PCR)
- UniSTS:280972

NoName (e-PCR)
- UniSTS:486845

WI-18702 (e-PCR)
- UniSTS:76794

NoName (e-PCR)
- UniSTS:480764

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables corticotropin-releasing hormone receptor 1 binding	IEA Inferred from Electronic Annotation more info
enables corticotropin-releasing hormone receptor 2 binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide hormone activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in aerobic respiration	IEA Inferred from Electronic Annotation more info
involved_in associative learning	IEA Inferred from Electronic Annotation more info
involved_in drinking behavior	IEA Inferred from Electronic Annotation more info
involved_in female pregnancy	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of appetite	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of blood pressure	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell size	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of feeding behavior	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of hormone secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA replication	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of behavioral fear response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cAMP-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of calcium ion import	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cardiac muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell growth	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of collagen biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of corticotropin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptidyl-serine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular permeability	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic transmission, glutamatergic	IEA Inferred from Electronic Annotation more info
involved_in response to auditory stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to estradiol	IEA Inferred from Electronic Annotation more info
involved_in response to glucocorticoid	IEA Inferred from Electronic Annotation more info
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in response to pain	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of sound	IEA Inferred from Electronic Annotation more info
involved_in social behavior	IEA Inferred from Electronic Annotation more info
involved_in startle response	IEA Inferred from Electronic Annotation more info
involved_in vasodilation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon terminus	IEA Inferred from Electronic Annotation more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in varicosity	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: urocortin

Names: prepro-urocortin; urocortin, preproprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.