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ccnd2.S cyclin D2 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 734882, updated on 4-Nov-2024

Summary

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Official Symbol
ccnd2.S
Official Full Name
cyclin D2 S homeolog
Primary source
Xenbase:XB-GENE-865455
Locus tag
XELAEV_18019930mg
See related
EnsemblRapid:ENSXLAG00005001045 AllianceGenome:Xenbase:XB-GENE-865455
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
ccnd2; ccnd2-a; ccnd2-b
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to act upstream of or within cell division; mitotic cell cycle phase transition; and regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to be located in cytoplasm and nuclear membrane. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); ductal carcinoma in situ; hepatitis B; and liver cancer (multiple). Orthologous to human CCND2 (cyclin D2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ccnd2.S in Genome Data Viewer
Location:
chromosome: 3S
Exon count:
7
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 3S NC_054376.1 (9502185..9629653)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 3S NC_030729.1 (9506525..9634449)

Chromosome 3S - NC_054376.1Genomic Context describing neighboring genes Neighboring gene poly(ADP-ribose) polymerase family member 11 S homeolog Neighboring gene uncharacterized LOC108712594 Neighboring gene TP53 induced glycolysis regulatory phosphatase S homeolog Neighboring gene fibroblast growth factor 23, gene 1 S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC132398

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mitotic cell cycle phase transition IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of cyclin-dependent protein kinase holoenzyme complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cyclin D2 S homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001096348.1 → NP_001089817.1  cyclin D2 S homeolog

    See identical proteins and their annotated locations for NP_001089817.1

    Status: PROVISIONAL

    Source sequence(s)
    BC106703
    UniProtKB/TrEMBL
    A0A974HQI4, Q3KPK0
    Related
    ENSXLAP00005003144.1, ENSXLAT00005003206.1
    Conserved Domains (2) summary
    pfam00134
    Location:26 → 152
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:154 → 257
    Cyclin_C; Cyclin, C-terminal domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054376.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    9502185..9629653
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018254469.2 → XP_018109958.1  cyclin D2 S homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J1MRK4
    Conserved Domains (1) summary
    cl40454
    Location:75 → 178
    CYCLIN_SF; Cyclin box fold superfamily

  2. XM_041587726.1 → XP_041443660.1  cyclin D2 S homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J1MRK4
    Conserved Domains (1) summary
    cl40454
    Location:75 → 178
    CYCLIN_SF; Cyclin box fold superfamily
Nucleotide Protein Strain
Heading Accession and Version

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