ncf4.L neutrophil cytosolic factor 4 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: ncf4.L
Official Full Name: neutrophil cytosolic factor 4 L homeolog
Primary source: Xenbase:XB-GENE-6255292
Locus tag: XELAEV_18023735mg
See related: EnsemblRapid:ENSXLAG00005028402 AllianceGenome:Xenbase:XB-GENE-6255292
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: ncf4
Summary: Predicted to enable phosphatidylinositol binding activity and superoxide-generating NADPH oxidase activator activity. Predicted to act upstream of or within phagocytosis; respiratory burst; and superoxide anion generation. Predicted to be located in cytoplasm. Predicted to be part of NADPH oxidase complex. Human ortholog(s) of this gene implicated in autosomal recessive chronic granulomatous disease 3 and rheumatoid arthritis. Orthologous to human NCF4 (neutrophil cytosolic factor 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 4L

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	4L	NC_054377.1 (121620876..121664113, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	4L	NC_030730.1 (116298520..116319988, complement)

Chromosome 4L - NC_054377.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables superoxide-generating NADPH oxidase activator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within phagocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within respiratory burst	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within superoxide anion generation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of NADPH oxidase complex	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neutrophil cytosolic factor 4 L homeolog

Names: neutrophil cytosolic factor 4, 40kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001096201.1 → NP_001089670.1 neutrophil cytosolic factor 4 L homeolog

See identical proteins and their annotated locations for NP_001089670.1

Status: PROVISIONAL

Source sequence(s)

BC103734

UniProtKB/TrEMBL

A0A974D791, Q3SYN3

Related

ENSXLAP00005084645.1, ENSXLAT00005086298.1

Conserved Domains (3) summary

cd06882
Location:19 → 141

PX_p40phox; The phosphoinositide binding Phox Homology domain of the p40phox subunit of NADPH oxidase

cd11869
Location:171 → 224

SH3_p40phox; Src Homology 3 domain of the p40phox subunit of NADPH oxidase

cl02720
Location:235 → 326

PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054377.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

121620876..121664113 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041589430.1 → XP_041445364.1 neutrophil cytosolic factor 4 L homeolog isoform X1

UniProtKB/TrEMBL

A0A974D791, Q3SYN3

Conserved Domains (3) summary

cd06882
Location:19 → 141

PX_p40phox; The phosphoinositide binding Phox Homology domain of the p40phox subunit of NADPH oxidase

cd11869
Location:171 → 224

SH3_p40phox; Src Homology 3 domain of the p40phox subunit of NADPH oxidase

cl02720
Location:235 → 326

PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...