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dppa2.L developmental pluripotency associated 2 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 734624, updated on 4-Nov-2024

Summary

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Official Symbol
dppa2.L
Official Full Name
developmental pluripotency associated 2 L homeolog
Primary source
Xenbase:XB-GENE-22065085
Locus tag
XELAEV_18001483mg
See related
EnsemblRapid:ENSXLAG00005020321 AllianceGenome:Xenbase:XB-GENE-22065085
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
dppa2; Dppa2/4
Summary
Predicted to enable chromatin binding activity. Predicted to act upstream of or within system development. Predicted to be located in nucleus. Orthologous to human DPPA2 (developmental pluripotency associated 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dppa2.L in Genome Data Viewer
Location:
chromosome: 9_10L
Exon count:
9
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 9_10L NC_054387.1 (133476875..133484443, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) Unplaced Scaffold NW_016694813.1 (2662948..2670615)

Chromosome 9_10L - NC_054387.1Genomic Context describing neighboring genes Neighboring gene provisional ortholog of nuclear FMR1 interacting protein 2 L homeolog Neighboring gene NME/NM23 nucleoside diphosphate kinase 2 L homeolog Neighboring gene seizure related 6 homolog like 2 L homeolog Neighboring gene dual specificity phosphatase 14 L homeolog Neighboring gene HIRA interacting protein 3 L homeolog Neighboring gene INO80 complex subunit E L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Chromatin-bound Xenopus Dppa2 shapes the nucleus by locally inhibiting microtubule assembly. Xue JZ, et al. Dev Cell, 2013 Oct 14. PMID 24075807, Free PMC Article
  2. Functional dissection of XDppa2/4 structural domains in Xenopus development. Siegel D, et al. Mech Dev, 2009 Dec. PMID 19772919
  3. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dppa2 directly inhibits microtubule polymerization.
    Title: Chromatin-bound Xenopus Dppa2 shapes the nucleus by locally inhibiting microtubule assembly.
  2. Overexpression and antisense morpholino-mediated knockdown experiments show that XDppa2/4 is required for embryogenesis in Xenopus.
    Title: Functional dissection of XDppa2/4 structural domains in Xenopus development.
  3. Immunodepletion experiments in Xenopus egg extracts show that Xenopus Dppa2 inhibits microtubule assembly and is required for nuclear formation.
    Title: Chromatin-bound Xenopus Dppa2 shapes the nucleus by locally inhibiting microtubule assembly.
Submit: New GeneRIF Correction

General gene information

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Homology

Clone Names

  • MGC115729

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within system development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
developmental pluripotency associated 2 L homeolog
Names
developmental pluripotency-associated 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001096099.1 → NP_001089568.1  developmental pluripotency associated 2 L homeolog

    See identical proteins and their annotated locations for NP_001089568.1

    Status: PROVISIONAL

    Source sequence(s)
    BC097923
    UniProtKB/TrEMBL
    Q4V7G6
    Conserved Domains (2) summary
    pfam02037
    Location:22 → 53
    SAP; SAP domain
    pfam14047
    Location:84 → 147
    DCR; Dppa2/4 conserved region

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054387.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    133476875..133484443 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018240006.2 → XP_018095495.1  developmental pluripotency associated 2 L homeolog isoform X3

    UniProtKB/TrEMBL
    A0A8J0U315
    Related
    ENSXLAP00005059517.1, ENSXLAT00005060966.1

  2. XM_018240005.2 → XP_018095494.1  developmental pluripotency associated 2 L homeolog isoform X2

    UniProtKB/TrEMBL
    A0A8J0U5U9

  3. XM_018240004.2 → XP_018095493.1  developmental pluripotency associated 2 L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J0U3V4
    Related
    ENSXLAP00005059531.1, ENSXLAT00005060979.1
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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