commd1.L copper metabolism domain containing 1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: commd1.L
Official Full Name: copper metabolism domain containing 1 L homeolog
Primary source: Xenbase:XB-GENE-961924
Locus tag: XELAEV_18026519mg
See related: EnsemblRapid:ENSXLAG00005013345 AllianceGenome:Xenbase:XB-GENE-961924
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: murr1; commd1
Summary: Predicted to act upstream of or within several processes, including negative regulation of protein localization to cell surface; negative regulation of sodium ion transmembrane transport; and regulation of protein metabolic process. Predicted to be located in endosome. Orthologous to human COMMD1 (copper metabolism domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 5L

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	5L	NC_054379.1 (32221663..32271605, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	5L	NC_030732.1 (31461619..31512152, complement)

Chromosome 5L - NC_054379.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Process	Evidence Code	Pubs
acts_upstream_of_or_within copper ion homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of protein localization to cell surface	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: copper metabolism domain containing 1 L homeolog

Names: copper metabolism (Murr1) domain containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001095984.1 → NP_001089453.1 copper metabolism domain containing 1 L homeolog

See identical proteins and their annotated locations for NP_001089453.1

Status: PROVISIONAL

Source sequence(s)

BC097550

UniProtKB/TrEMBL

Q4V846

Related

ENSXLAP00005039383.1, ENSXLAT00005040305.1

Conserved Domains (1) summary

cd04749
Location:10 → 183

Commd1_MURR1; COMM_Domain containing protein 1, also called Murr1. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. The COMM Domain is found at the C-terminus of a ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054379.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

32221663..32271605 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_018262087.2 → XP_018117576.1 copper metabolism domain containing 1 L homeolog isoform X1

UniProtKB/TrEMBL

A0A1L8G7A6, A0A974CVS3
XM_018262085.2 → XP_018117574.1 copper metabolism domain containing 1 L homeolog isoform X1

UniProtKB/TrEMBL

A0A1L8G7A6, A0A974CVS3
XM_041562314.1 → XP_041418248.1 copper metabolism domain containing 1 L homeolog isoform X2

UniProtKB/TrEMBL

A0A8J1KNE2

Conserved Domains (1) summary

cd04749
Location:10 → 152

Commd1_MURR1; COMM_Domain containing protein 1, also called Murr1. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. The COMM Domain is found at the C-terminus of a ...
XM_041562315.1 → XP_041418249.1 copper metabolism domain containing 1 L homeolog isoform X3

UniProtKB/TrEMBL

A0A8J1KPU1

Conserved Domains (1) summary

cd04749
Location:10 → 152

Commd1_MURR1; COMM_Domain containing protein 1, also called Murr1. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. The COMM Domain is found at the C-terminus of a ...