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fbln1.L fibulin 1 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 734480, updated on 4-Nov-2024

Summary

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Official Symbol
fbln1.L
Official Full Name
fibulin 1 L homeolog
Primary source
Xenbase:XB-GENE-5761829
Locus tag
XELAEV_18016663mg
See related
EnsemblRapid:ENSXLAG00005009175 AllianceGenome:Xenbase:XB-GENE-5761829
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
fbln1; cnpr03
Summary
Predicted to enable calcium ion binding activity and peptidase activator activity. Predicted to act upstream of or within extracellular matrix organization. Predicted to be located in extracellular region. Is expressed in endoderm. Orthologous to human FBLN1 (fibulin 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See fbln1.L in Genome Data Viewer
Location:
chromosome: 3L
Exon count:
18
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 3L NC_054375.1 (3023617..3052754, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 3L NC_030728.1 (2764476..2794009, complement)

Chromosome 3L - NC_054375.1Genomic Context describing neighboring genes Neighboring gene Wnt family member 7B L homeolog Neighboring gene ataxin 10 L homeolog Neighboring gene uncharacterized LOC121401353 Neighboring gene RIB43A domain with coiled-coils 2 L homeolog Neighboring gene structural maintenance of chromosomes 1B L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An atlas of differential gene expression during early Xenopus embryogenesis. Pollet N, et al. Mech Dev, 2005 Mar. PMID 15763213
  2. Axeldb: a Xenopus laevis database focusing on gene expression. Pollet N, et al. Nucleic Acids Res, 2000 Jan 1. PMID 10592204, Free PMC Article
  3. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC115035

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
fibulin 1 L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001095961.1 → NP_001089430.1  fibulin 1 L homeolog precursor

    See identical proteins and their annotated locations for NP_001089430.1

    Status: PROVISIONAL

    Source sequence(s)
    BC094478
    UniProtKB/TrEMBL
    Q505M8
    Related
    ENSXLAP00005026842.1, ENSXLAT00005027574.1
    Conserved Domains (7) summary
    smart00179
    Location:299 → 346
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:347 → 379
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07645
    Location:516 → 556
    EGF_CA; Calcium-binding EGF domain
    pfam12662
    Location:495 → 519
    cEGF; Complement Clr-like EGF-like
    cl00032
    Location:86 → 141
    ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
    cl00057
    Location:205 → 249
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    cl21504
    Location:253 → 289
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054375.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    3023617..3052754 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041585249.1 → XP_041441183.1  fibulin 1 L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J1MI53
    Conserved Domains (6) summary
    smart00179
    Location:300 → 347
    EGF_CA; Calcium-binding EGF-like domain
    cd00017
    Location:86 → 142
    ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
    cd00054
    Location:348 → 380
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07645
    Location:517 → 557
    EGF_CA; Calcium-binding EGF domain
    cl00057
    Location:206 → 250
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    cl21504
    Location:254 → 297
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

  2. XM_041585251.1 → XP_041441185.1  fibulin 1 L homeolog isoform X3

    UniProtKB/TrEMBL
    A0A8J1MJG9
    Related
    ENSXLAP00005026826.1, ENSXLAT00005027558.1
    Conserved Domains (6) summary
    smart00179
    Location:299 → 346
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:347 → 379
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07645
    Location:516 → 559
    EGF_CA; Calcium-binding EGF domain
    cl00032
    Location:86 → 141
    ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
    cl00057
    Location:205 → 249
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    cl21504
    Location:253 → 296
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

  3. XM_041585250.1 → XP_041441184.1  fibulin 1 L homeolog isoform X2

    UniProtKB/TrEMBL
    A0A8J1MHI4
    Conserved Domains (6) summary
    smart00179
    Location:300 → 347
    EGF_CA; Calcium-binding EGF-like domain
    cd00017
    Location:86 → 142
    ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
    cd00054
    Location:348 → 380
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07645
    Location:517 → 560
    EGF_CA; Calcium-binding EGF domain
    cl00057
    Location:206 → 250
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    cl21504
    Location:254 → 297
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
Nucleotide Protein Strain
Heading Accession and Version

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