pepd.L peptidase D L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: pepd.L
Official Full Name: peptidase D L homeolog
Primary source: Xenbase:XB-GENE-944086
Locus tag: XELAEV_18022731mg
See related: EnsemblRapid:ENSXLAG00005015572 AllianceGenome:Xenbase:XB-GENE-944086
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: pepd
Summary: Predicted to enable manganese ion binding activity and metalloaminopeptidase activity. Human ortholog(s) of this gene implicated in prolidase deficiency. Orthologous to human PEPD (peptidase D). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 4L

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	4L	NC_054377.1 (62499717..62634850)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	4L	NC_030730.1 (57284397..57419832)

Chromosome 4L - NC_054377.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables manganese ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloaminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: peptidase D L homeolog

NP_001089413.1

EC 3.4.13.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001095944.1 → NP_001089413.1 peptidase D L homeolog

See identical proteins and their annotated locations for NP_001089413.1

Status: PROVISIONAL

Source sequence(s)

BC094190

UniProtKB/TrEMBL

A0A974D2U2, Q52KU0

Related

ENSXLAP00005045785.1, ENSXLAT00005046884.1

Conserved Domains (3) summary

smart01011
Location:18 → 155

AMP_N; Aminopeptidase P, N-terminal domain

COG0006
Location:60 → 476

PepP; Xaa-Pro aminopeptidase [Amino acid transport and metabolism]

cd01087
Location:192 → 467

Prolidase; Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on ...