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nfkbia.S NFKB inhibitor alpha S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 734297, updated on 4-Nov-2024

Summary

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Official Symbol
nfkbia.S
Official Full Name
NFKB inhibitor alpha S homeolog
Primary source
Xenbase:XB-GENE-17331094
Locus tag
XELAEV_18041036mg
See related
EnsemblRapid:ENSXLAG00005022712 AllianceGenome:Xenbase:XB-GENE-17331094
Gene type
protein coding
RefSeq status
PREDICTED
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Summary
Predicted to enable NF-kappaB binding activity. Predicted to act upstream of or within cellular response to tumor necrosis factor; cytoplasmic sequestering of NF-kappaB; and toll-like receptor 4 signaling pathway. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in several diseases, including childhood-onset asthma; ectodermal dysplasia and immunodeficiency 2; hematologic cancer (multiple); hepatitis B; and lung disease (multiple). Orthologous to human NFKBIA (NFKB inhibitor alpha). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: partial on reference assembly
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Genomic context

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See nfkbia.S in Genome Data Viewer
Location:
chromosome: 8S
Exon count:
6
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8S NC_054386.1 (2870106..2877366)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 8S NC_030739.1 (2857712..2864986)

Chromosome 8S - NC_054386.1Genomic Context describing neighboring genes Neighboring gene actinin alpha 1 S homeolog Neighboring gene serine/arginine-rich splicing factor 5 alpha S homeolog Neighboring gene proteasome subunit alpha 6 S homeolog Neighboring gene family with sequence similarity 177 member A1 S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC84886

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables NF-kappaB binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to tumor necrosis factor IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cytoplasmic sequestering of NF-kappaB IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within toll-like receptor 4 signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein LOC734297
Names
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha S homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001095781.1 → NP_001089250.1  uncharacterized protein LOC734297

    See identical proteins and their annotated locations for NP_001089250.1

    Status: PREDICTED

    Source sequence(s)
    BC089274
    UniProtKB/TrEMBL
    A0A974C1R8, Q5FWN1
    Related
    ENSXLAP00005066913.1, ENSXLAT00005068443.1
    Conserved Domains (4) summary
    cd00204
    Location:105 → 236
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:115 → 211
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:201 → 255
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:143 → 179
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054386.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    2870106..2877366
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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