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dnajb6.L DnaJ heat shock protein family (Hsp40) member B6 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 734291, updated on 4-Nov-2024

Summary

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Official Symbol
dnajb6.L
Official Full Name
DnaJ heat shock protein family (Hsp40) member B6 L homeolog
Primary source
Xenbase:XB-GENE-954099
Locus tag
XELAEV_18030684mg
See related
EnsemblRapid:ENSXLAG00005023113 AllianceGenome:Xenbase:XB-GENE-954099
Gene type
protein coding
RefSeq status
MODEL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
DnaJ; hsj2; dnajb6-a; dnajb6-b
Summary
Predicted to enable Hsp70 protein binding activity and unfolded protein binding activity. Predicted to act upstream of or within chaperone-mediated protein folding. Predicted to be located in nucleus and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy type 1. Orthologous to human DNAJB6 (DnaJ heat shock protein family (Hsp40) member B6). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dnajb6.L in Genome Data Viewer
Location:
chromosome: 6L
Exon count:
10
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 6L NC_054381.1 (16242861..16302365)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 6L NC_030734.1 (13791760..13830934)

Chromosome 6L - NC_054381.1Genomic Context describing neighboring genes Neighboring gene ubiquitin protein ligase E3C L homeolog Neighboring gene uncharacterized LOC121394852 Neighboring gene protein tyrosine phosphatase receptor type N2 L homeolog Neighboring gene non-SMC condensin II complex subunit G2 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DnaJB6 is a RanGTP-regulated protein required for microtubule organization during mitosis. Rosas-Salvans M, et al. J Cell Sci, 2019 Jun 3. PMID 31064815, Free PMC Article
  2. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. Kırlı K, et al. Elife, 2015 Dec 17. PMID 26673895, Free PMC Article
  3. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC85133

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables Hsp70 protein binding IEA
Inferred from Electronic Annotation
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chaperone-mediated protein folding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dnaJ homolog subfamily B member 6-A
Names
DnaJ heat shock protein family member B6 long isoform

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054381.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    16242861..16302365
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041565800.1 → XP_041421734.1  dnaJ homolog subfamily B member 6-A isoform X1

    UniProtKB/TrEMBL
    A0A8J1KYC6
    Conserved Domains (1) summary
    PRK10767
    Location:4 → 133
    PRK10767; chaperone protein DnaJ; Provisional

  2. XM_041565799.1 → XP_041421733.1  dnaJ homolog subfamily B member 6-A isoform X1

    UniProtKB/TrEMBL
    A0A8J1KYC6
    Related
    ENSXLAP00005068181.1, ENSXLAT00005069715.1
    Conserved Domains (1) summary
    PRK10767
    Location:4 → 133
    PRK10767; chaperone protein DnaJ; Provisional

  3. XM_041565801.1 → XP_041421735.1  dnaJ homolog subfamily B member 6-A isoform X2

    UniProtKB/TrEMBL
    A0A1L8FVA1, A0A974CLD7
    Related
    ENSXLAP00005068281.1, ENSXLAT00005069814.1
    Conserved Domains (1) summary
    PRK10767
    Location:4 → 133
    PRK10767; chaperone protein DnaJ; Provisional

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001095775.1: Suppressed sequence

    Description
    NM_001095775.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5FWN8.1 GenPept UniProtKB/Swiss-Prot:Q5FWN8

Gene LinkOut

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