fbn3.L fibrillin 3 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: fbn3.L
Official Full Name: fibrillin 3 L homeolog
Primary source: Xenbase:XB-GENE-1217680
Locus tag: XELAEV_18006064mg
See related: EnsemblRapid:ENSXLAG00005023911 AllianceGenome:Xenbase:XB-GENE-1217680
Gene type: protein coding
RefSeq status: MODEL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: fbn3
Summary: Predicted to enable calcium ion binding activity. Predicted to be located in extracellular region and microfibril. Is expressed in anatomical system; mesenchyme; and primary germ layer. Orthologous to human FBN3 (fibrillin 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 1L

Exon count:: 66

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	1L	NC_054371.1 (99251870..99385699, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	1L	NC_030724.1 (87797852..87932245, complement)

Chromosome 1L - NC_054371.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

suggested that one role for XF is to serve as a mechanical element in the embryo prior to bone deposition
Title: Xenopus fibrillin is expressed in the organizer and is the earliest component of matrix at the developing notochord-somite boundary.
native Xenopus fibrillin is essential for the process of directed convergent extension in presumptive notochord at gastrulation
Title: Xenopus fibrillin regulates directed convergence and extension.

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General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in microfibril	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: fibrillin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054371.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

99251870..99385699 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041560951.1 → XP_041416885.1 fibrillin-2 isoform X2

UniProtKB/TrEMBL

A0A8J1KHP0, A0A974DTX7

Related

ENSXLAP00005071270.1, ENSXLAT00005072816.1

Conserved Domains (5) summary

smart00179
Location:528 → 569

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:2189 → 2221

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam07645
Location:291 → 331

EGF_CA; Calcium-binding EGF domain

cl00057
Location:1176 → 1216

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

cl21504
Location:891 → 931

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
XM_041560952.1 → XP_041416886.1 fibrillin-2 isoform X3

UniProtKB/TrEMBL

A0A8J1KHR7, A0A974DTX7

Conserved Domains (5) summary

smart00179
Location:528 → 569

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:2163 → 2195

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam07645
Location:291 → 331

EGF_CA; Calcium-binding EGF domain

cl00057
Location:1193 → 1233

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

cl21504
Location:908 → 948

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
XM_018253947.2 → XP_018109436.1 fibrillin-2 isoform X1

UniProtKB/TrEMBL

A0A1L8HW58, A0A974DTX7, A0A974I3S6

Related

ENSXLAP00005071037.1, ENSXLAT00005072584.1
XM_018253949.2 → XP_018109438.1 fibrillin-2 isoform X4

UniProtKB/TrEMBL

A0A8J0UX98, A0A974DTX7