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OSGIN2 oxidative stress induced growth inhibitor family member 2 [ Homo sapiens (human) ]

Gene ID: 734, updated on 5-Mar-2024

Summary

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Official Symbol
OSGIN2provided by HGNC
Official Full Name
oxidative stress induced growth inhibitor family member 2provided by HGNC
Primary source
HGNC:HGNC:1355
See related
Ensembl:ENSG00000164823 MIM:604598; AllianceGenome:HGNC:1355
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
hT41; C8orf1
Summary
Predicted to enable growth factor activity. Predicted to be involved in negative regulation of cell growth. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in fat (RPKM 10.6), brain (RPKM 9.0) and 25 other tissues See more
Orthologs
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Genomic context

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See OSGIN2 in Genome Data Viewer
Location:
8q21.3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (89901868..89927888)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (91025051..91051069)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (90914096..90940116)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27606 Neighboring gene cytochrome c oxidase subunit 6B1 pseudogene 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27607 Neighboring gene MPRA-validated peak7104 silencer Neighboring gene Sharpr-MPRA regulatory region 7187 Neighboring gene uncharacterized LOC124901974 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:90912677-90913442 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:90913443-90914208 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19347 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:90914502-90914800 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19348 Neighboring gene RNA, U6 small nuclear 925, pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:90959982-90961181 Neighboring gene nibrin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27608 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:90996459-90997255 Neighboring gene Sharpr-MPRA regulatory region 13813 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19350 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27609 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27610 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27611 Neighboring gene 2,4-dienoyl-CoA reductase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Sequence analysis of an 800-kb genomic DNA region on chromosome 8q21 that contains the Nijmegen breakage syndrome gene, NBS1. Tauchi H, et al. Genomics, 1999 Jan 15. PMID 9933573
  2. Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint. Bailey ML, et al. Genetics, 2015 Nov. PMID 26354767, Free PMC Article
  3. Transcriptome analysis of human gastric cancer. Oh JH, et al. Mamm Genome, 2005 Dec. PMID 16341674
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. Abdelmohsen K, et al. EMBO J, 2009 May 6. PMID 19322201, Free PMC Article
  5. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. Capalbo L, et al. Nat Commun, 2019 Oct 4. PMID 31586073, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell growth IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
oxidative stress-induced growth inhibitor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001126111.3 → NP_001119583.1  oxidative stress-induced growth inhibitor 2 isoform 1

    See identical proteins and their annotated locations for NP_001119583.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate 5'UTR that includes a translation start site that is upstream and in-frame with that used for variant 2. The resulting protein (isoform 1) is longer and has a distinct N-terminus compared to isoform 2.
    Source sequence(s)
    AF061326, BC031054, BM764021, BU739360
    Consensus CDS
    CCDS47888.1
    UniProtKB/Swiss-Prot
    Q9Y236
    Related
    ENSP00000396445.2, ENST00000451899.7
    Conserved Domains (1) summary
    cl21454
    Location:217 → 363
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. NM_004337.2 → NP_004328.1  oxidative stress-induced growth inhibitor 2 isoform 2

    See identical proteins and their annotated locations for NP_004328.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5'UTR resulting in translation initiation from an internal AUG site compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
    Source sequence(s)
    AF061326, BC031054, BU688773
    Consensus CDS
    CCDS6248.1
    UniProtKB/Swiss-Prot
    Q9Y236
    Related
    ENSP00000297438.2, ENST00000297438.6
    Conserved Domains (1) summary
    cl21454
    Location:173 → 319
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    89901868..89927888
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517287.4 → XP_011515589.1  oxidative stress-induced growth inhibitor 2 isoform X1

    See identical proteins and their annotated locations for XP_011515589.1

    UniProtKB/Swiss-Prot
    Q9Y236
    Conserved Domains (1) summary
    cl21454
    Location:173 → 319
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. XM_011517288.4 → XP_011515590.1  oxidative stress-induced growth inhibitor 2 isoform X2

    Conserved Domains (1) summary
    cl21454
    Location:40 → 186
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    91025051..91051069
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361178.1 → XP_054217153.1  oxidative stress-induced growth inhibitor 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9Y236

  2. XM_054361179.1 → XP_054217154.1  oxidative stress-induced growth inhibitor 2 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y236.1 GenPept UniProtKB/Swiss-Prot:Q9Y236

Gene LinkOut

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