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aspa aspartoacylase [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 733935, updated on 4-Nov-2024

Summary

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Official Symbol
aspaprovided by Xenbase
Official Full Name
aspartoacylaseprovided by Xenbase
Primary source
Xenbase:XB-GENE-1016250
See related
Ensembl:ENSXETG00000005789 AllianceGenome:Xenbase:XB-GENE-1016250
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as
asp; acy2; ACY-2
Summary
Predicted to enable hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Canavan disease. Orthologous to human ASPA (aspartoacylase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See aspa in Genome Data Viewer
Location:
chromosome: 2
Exon count:
8
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 2 NC_030678.2 (30549756..30559087)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 2 NC_030678.1 (31985129..31994457, complement)

Chromosome 2 - NC_030678.2Genomic Context describing neighboring genes Neighboring gene transmembrane protein 211-like Neighboring gene spermatogenesis associated 22 Neighboring gene transient receptor potential cation channel, subfamily V, member 3 Neighboring gene transient receptor potential cation channel, subfamily V, member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
aspartoacylase
Names
Aminoacylase-2
aspartoacylase (Canavan disease)
aspartoacylase (aminoacylase 2, Canavan disease)
NP_001039114.1
XP_012812617.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045649.1 → NP_001039114.1  aspartoacylase

    See identical proteins and their annotated locations for NP_001039114.1

    Status: PROVISIONAL

    Source sequence(s)
    CR942438
    UniProtKB/Swiss-Prot
    B0JZ84, Q28C61
    Related
    ENSXETP00000012735.4, ENSXETT00000012735.5
    Conserved Domains (2) summary
    cd06909
    Location:11 → 299
    M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily
    pfam04952
    Location:9 → 294
    AstE_AspA; Succinylglutamate desuccinylase / Aspartoacylase family

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030678.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    30549756..30559087
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012957163.3 → XP_012812617.2  aspartoacylase isoform X1

    UniProtKB/Swiss-Prot
    B0JZ84, Q28C61
    UniProtKB/TrEMBL
    A0A8J0S7X8
    Conserved Domains (1) summary
    cd06909
    Location:44 → 238
    M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q28C61.2 GenPept UniProtKB/Swiss-Prot:Q28C61

Gene LinkOut

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