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AKR1C3 aldo-keto reductase family 1 member C3 [ Sus scrofa (pig) ]

Gene ID: 733694, updated on 11-Apr-2024

Summary

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Gene symbol
AKR1C3
Gene description
aldo-keto reductase family 1 member C3
See related
Ensembl:ENSSSCG00000062058
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
AKR1C1
Expression
Biased expression in kidney (RPKM 111.2), mixtures (RPKM 27.8) and 2 other tissues See more
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Genomic context

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See AKR1C3 in Genome Data Viewer
Location:
chromosome: 10
Exon count:
14
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 10 NC_010452.4 (65650223..65679878)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 10 NC_010452.3 (71902088..71931228)

Chromosome 10 - NC_010452.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102167589 Neighboring gene aldo-keto reductase family 1, member C1 Neighboring gene putative aldo-keto reductase family 1 member C2 Neighboring gene aldo-keto reductase family 1 member E2 Neighboring gene malignant T-cell-amplified sequence 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Structural importance of the C-terminal region in pig aldo-keto reductase family 1 member C1 and their effects on enzymatic activity. Son M, et al. BMC Struct Biol, 2015 Jan 13. PMID 25583233, Free PMC Article
  2. Expression and localization of 20α-hydroxysteroid dehydrogenase (20α-HSD) in porcine reproductive tissues during pregnancy. Nanjidsuren T, et al. Anim Reprod Sci, 2014 Jul. PMID 24875897
  3. Flutamide influences placental aldo-keto reductase family 1 member C1 (AKR1C1) expression in pigs. Grzesiak M, et al. Reprod Domest Anim, 2014 Feb. PMID 24303814
  4. Expression of aldo-keto reductase family 1 member C1 (AKR1C1) gene in porcine ovary and uterine endometrium during the estrous cycle and pregnancy. Seo KS, et al. Reprod Biol Endocrinol, 2011 Oct 20. PMID 22014308, Free PMC Article
  5. Aldo-keto reductase 1C subfamily genes in skin are UV-inducible: possible role in keratinocytes survival. Marín YE, et al. Exp Dermatol, 2009 Jul. PMID 19320734

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Studied molecular modeling studies combined with kinetic experiments to examine structural difference between wild-type AKR1C1 (C-type) and C-terminal-truncated AKR1C1 (T-type) for 5alpha-DHT; findings provide structural insights into important role of C-terminal region of the enzyme.
    Title: Structural importance of the C-terminal region in pig aldo-keto reductase family 1 member C1 and their effects on enzymatic activity.
  2. This determined that 20alpha-HSD mRNA was demonstrated to have the highest expression in the placenta on day 30 of pregnancy and in the ovary during pre-parturition.
    Title: Expression and localization of 20α-hydroxysteroid dehydrogenase (20α-HSD) in porcine reproductive tissues during pregnancy.
  3. porcine placental Aldo-keto reductase family 1 member C1(AKR1C1) expression seems to be regulated by an androgen signalling pathway and may be involved in foetal survival by preventing the detrimental effect of progesterone
    Title: Flutamide influences placental aldo-keto reductase family 1 member C1 (AKR1C1) expression in pigs.
  4. Data indicate that AKR1C1 mRNA/protein coordinately expressed in luteal cells/ovary throughout estrous cycle and in endometrium on D30 of pregnancy. Here, cloned cDNA differs in C-terminus (stop codon; deletion = 4 amino acids) from previous report.
    Title: Expression of aldo-keto reductase family 1 member C1 (AKR1C1) gene in porcine ovary and uterine endometrium during the estrous cycle and pregnancy.
  5. AKR1C subfamily genes are stress-inducible and might function as survival factors in keratinocytes.
    Title: Aldo-keto reductase 1C subfamily genes in skin are UV-inducible: possible role in keratinocytes survival.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables aldose reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables androsterone dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables bile acid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ketosteroid monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in daunorubicin metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in doxorubicin metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in progesterone metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in prostaglandin metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
aldo-keto reductase family 1 member C1
Names
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
putative aldo-keto reductase family 1 member C3
NP_001038083.1
XP_005668287.1
XP_005668288.1
XP_005668289.1
XP_005668293.1
XP_013835808.1
XP_020919737.1
XP_020919738.1
XP_020919739.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044618.1 → NP_001038083.1  aldo-keto reductase family 1 member C1

    See identical proteins and their annotated locations for NP_001038083.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ474067
    UniProtKB/TrEMBL
    A0A4X1T4T7, Q1KLB2
    Related
    ENSSSCP00000042336.1, ENSSSCT00000057350.3
    Conserved Domains (2) summary
    COG0656
    Location:2 → 303
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:5 → 299
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010452.4 Reference Sscrofa11.1 Primary Assembly

    Range
    65650223..65679878
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005668230.2 → XP_005668287.1  aldo-keto reductase family 1 member C1 isoform X1

    See identical proteins and their annotated locations for XP_005668287.1

    UniProtKB/TrEMBL
    A0A480SLU2, A0A8D0Z8G0, A0A8D1ZRQ7, D0G0C4
    Conserved Domains (2) summary
    COG0656
    Location:2 → 303
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:5 → 299
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

  2. XM_021064079.1 → XP_020919738.1  aldo-keto reductase family 1 member C1 isoform X3

    Conserved Domains (1) summary
    COG0656
    Location:2 → 226
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]

  3. XM_021064080.1 → XP_020919739.1  aldo-keto reductase family 1 member C1 isoform X4

    Conserved Domains (1) summary
    COG0656
    Location:2 → 193
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]

  4. XM_021064078.1 → XP_020919737.1  aldo-keto reductase family 1 member C1 isoform X2

    UniProtKB/TrEMBL
    A0A8D1IC59, F1RYU4
    Conserved Domains (1) summary
    COG0656
    Location:2 → 284
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]

  5. XM_005668232.3 → XP_005668289.1  aldo-keto reductase family 1 member C1 isoform X1

    See identical proteins and their annotated locations for XP_005668289.1

    UniProtKB/TrEMBL
    A0A480SLU2, A0A8D0Z8G0, A0A8D1ZRQ7, D0G0C4
    Conserved Domains (2) summary
    COG0656
    Location:2 → 303
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:5 → 299
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

  6. XM_005668231.3 → XP_005668288.1  aldo-keto reductase family 1 member C1 isoform X1

    See identical proteins and their annotated locations for XP_005668288.1

    UniProtKB/TrEMBL
    A0A480SLU2, A0A8D0Z8G0, A0A8D1ZRQ7, D0G0C4
    Conserved Domains (2) summary
    COG0656
    Location:2 → 303
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:5 → 299
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

  7. XM_005668236.3 → XP_005668293.1  aldo-keto reductase family 1 member C1 isoform X1

    See identical proteins and their annotated locations for XP_005668293.1

    UniProtKB/TrEMBL
    A0A480SLU2, A0A8D0Z8G0, A0A8D1ZRQ7, D0G0C4
    Related
    ENSSSCP00000026498.2, ENSSSCT00000032108.4
    Conserved Domains (2) summary
    COG0656
    Location:2 → 303
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:5 → 299
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

  8. XM_013980354.2 → XP_013835808.1  aldo-keto reductase family 1 member C1 isoform X1

    UniProtKB/TrEMBL
    A0A480SLU2, A0A8D0Z8G0, A0A8D1ZRQ7, D0G0C4
    Conserved Domains (2) summary
    COG0656
    Location:2 → 303
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:5 → 299
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]
Nucleotide Protein
Heading Accession and Version

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