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ngly1.S N-glycanase 1 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 733299, updated on 4-Nov-2024

Summary

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Official Symbol
ngly1.S
Official Full Name
N-glycanase 1 S homeolog
Primary source
Xenbase:XB-GENE-963944
Locus tag
XELAEV_18033126mg
See related
EnsemblRapid:ENSXLAG00005003856 AllianceGenome:Xenbase:XB-GENE-963944
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
ngly1
Summary
Predicted to enable metal ion binding activity and peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity. Predicted to act upstream of or within glycoprotein catabolic process; protein deglycosylation; and protein quality control for misfolded or incompletely synthesized proteins. Predicted to be located in cytosol and nucleus. Human ortholog(s) of this gene implicated in congenital disorder of deglycosylation 1. Orthologous to human NGLY1 (N-glycanase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ngly1.S in Genome Data Viewer
Location:
chromosome: 6S
Exon count:
12
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 6S NC_054382.1 (40275881..40295491, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 6S NC_030735.1 (39213860..39233601, complement)

Chromosome 6S - NC_054382.1Genomic Context describing neighboring genes Neighboring gene retinoic acid receptor beta S homeolog Neighboring gene DNA topoisomerase II beta S homeolog Neighboring gene 3-oxoacyl-ACP synthase, mitochondrial S homeolog Neighboring gene leucine rich repeat containing 3B S homeolog Neighboring gene solute carrier family 4, sodium bicarbonate cotransporter, member 7 S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within glycoprotein catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein deglycosylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein quality control for misfolded or incompletely synthesized proteins IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
N-glycanase 1 S homeolog
NP_001116357.1
XP_018124280.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122885.1 → NP_001116357.1  N-glycanase 1 S homeolog

    See identical proteins and their annotated locations for NP_001116357.1

    Status: PROVISIONAL

    Source sequence(s)
    BC124906
    UniProtKB/TrEMBL
    A0A974CL30, Q08B23
    Related
    ENSXLAP00005011517.1, ENSXLAT00005011691.1
    Conserved Domains (6) summary
    cd10459
    Location:9 → 101
    PUB_PNGase; PNGase/UBA or UBX (PUB) domain of the P97 adaptor protein Peptide:N-glycanase (PNGase)
    COG1305
    Location:274 → 351
    YebA; Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones]
    pfam01841
    Location:256 → 335
    Transglut_core; Transglutaminase-like superfamily
    pfam03835
    Location:319 → 415
    Rad4; Rad4 transglutaminase-like domain
    pfam04721
    Location:438 → 632
    PAW; PNGase C-terminal domain, mannose-binding module PAW
    pfam16643
    Location:88 → 140
    cNMPbd_u2; Unstructured region on cNMP-binding protein

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054382.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    40275881..40295491 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018268791.2 → XP_018124280.1  N-glycanase 1 S homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J0VPX6
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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