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Mir12 microRNA mir-12 [ Apis mellifera (honey bee) ]

Gene ID: 732492, updated on 22-Apr-2023

Summary

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Gene symbol
Mir12
Gene description
microRNA mir-12
See related
miRBase:MI0001576
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Apis mellifera
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea; Anthophila; Apidae; Apis
Also known as
Mirn12; ame-mir-12
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

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See Mir12 in Genome Data Viewer
Location:
chromosome: LG2
Exon count:
1
Annotation release Status Assembly LG Location
104 current Amel_HAv3.1 (GCF_003254395.2) LG2 NC_037639.1 (4840914..4840996, complement)
103 previous assembly Amel_4.5 (GCF_000002195.4) LG2 NC_007071.3 (3362974..3363056, complement)

Linkage Group LG2 - NC_037639.1Genomic Context describing neighboring genes Neighboring gene protein lethal(2)essential for life Neighboring gene protein lethal(2)essential for life Neighboring gene thyroid receptor-interacting protein 11 Neighboring gene microRNA mir-3477 Neighboring gene microRNA mir-283

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. miR-12 and miR-124 contribute to defined early phases of long-lasting and transient memory. Michely J, et al. Sci Rep, 2017 Aug 11. PMID 28801686, Free PMC Article
  2. Correlated expression patterns of microRNA genes with age-dependent behavioural changes in honeybee. Behura SK, et al. Insect Mol Biol, 2010 Aug. PMID 20491979
  3. Behavioral plasticity in honey bees is associated with differences in brain microRNA transcriptome. Greenberg JK, et al. Genes Brain Behav, 2012 Aug. PMID 22409512, Free PMC Article
  4. ProtoBee: hierarchical classification and annotation of the honey bee proteome. Kaplan N, et al. Genome Res, 2006 Nov. PMID 17065614, Free PMC Article
  5. miRBase: microRNA sequences, targets and gene nomenclature. Griffiths-Jones S, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381832, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Other Names

  • microRNA 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_031509.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    QIUM02000011

RefSeqs of Annotated Genomes: Apis mellifera Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Amel_HAv3.1 Primary Assembly

Genomic

  1. NC_037639.1 Reference Amel_HAv3.1 Primary Assembly

    Range
    4840914..4840996 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.