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Fam118a family with sequence similarity 118, member A [ Mus musculus (house mouse) ]

Gene ID: 73225, updated on 28-Oct-2024

Summary

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Official Symbol
Fam118aprovided by MGI
Official Full Name
family with sequence similarity 118, member Aprovided by MGI
Primary source
MGI:MGI:1920475
See related
Ensembl:ENSMUSG00000022434 AllianceGenome:MGI:1920475
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable identical protein binding activity. Predicted to be located in membrane. Is expressed in cerebral cortex and cerebral cortex marginal layer. Orthologous to human FAM118A (family with sequence similarity 118 member A). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in testis adult (RPKM 12.6), bladder adult (RPKM 8.8) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Fam118a in Genome Data Viewer
Location:
15 E2; 15 40.25 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (84921263..85001781)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (85037062..85117580)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene SET translocation pseudogene Neighboring gene predicted gene, 52194 Neighboring gene uroplakin 3A Neighboring gene STARR-seq mESC enhancer starr_39377 Neighboring gene structural maintenance of chromosomes 1B Neighboring gene ribosomal protein L23A pseudogene Neighboring gene RIB43A domain with coiled-coils 2 Neighboring gene predicted gene, 19277

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  2. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Homology

Clone Names

  • 3110048E14Rik, C230014M12Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein FAM118A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356616.1 → NP_001343545.1  protein FAM118A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL772308
    Consensus CDS
    CCDS27717.1
    UniProtKB/Swiss-Prot
    Q3UP97, Q8C4H6, Q8C5E1, Q91YN1
    Related
    ENSMUSP00000154985.2, ENSMUST00000229203.2
    Conserved Domains (1) summary
    pfam13289
    Location:142 → 247
    SIR2_2; SIR2-like domain

  2. NM_001356617.1 → NP_001343546.1  protein FAM118A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL772308
    Conserved Domains (1) summary
    pfam13289
    Location:142 → 247
    SIR2_2; SIR2-like domain

  3. NM_001356618.1 → NP_001343547.1  protein FAM118A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL772308
    Conserved Domains (1) summary
    pfam13289
    Location:142 → 247
    SIR2_2; SIR2-like domain

  4. NM_001378838.1 → NP_001365767.1  protein FAM118A isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL772308
    Conserved Domains (1) summary
    pfam13289
    Location:142 → 247
    SIR2_2; SIR2-like domain

  5. NM_001378839.1 → NP_001365768.1  protein FAM118A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL772308
    Conserved Domains (1) summary
    pfam13289
    Location:142 → 247
    SIR2_2; SIR2-like domain

  6. NM_001378840.1 → NP_001365769.1  protein FAM118A isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL772308
    Conserved Domains (1) summary
    pfam13289
    Location:149 → 254
    SIR2_2; SIR2-like domain

  7. NM_001378841.1 → NP_001365770.1  protein FAM118A isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL772308
    Conserved Domains (1) summary
    pfam13289
    Location:149 → 254
    SIR2_2; SIR2-like domain

  8. NM_001378842.1 → NP_001365771.1  protein FAM118A isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL772308
    Conserved Domains (1) summary
    pfam13289
    Location:142 → 247
    SIR2_2; SIR2-like domain

  9. NM_001378843.1 → NP_001365772.1  protein FAM118A isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL772308
    Conserved Domains (1) summary
    pfam13289
    Location:44 → 149
    SIR2_2; SIR2-like domain

  10. NM_133750.4 → NP_598511.1  protein FAM118A isoform 2

    See identical proteins and their annotated locations for NP_598511.1

    Status: VALIDATED

    Source sequence(s)
    BC066174, CJ084461
    Consensus CDS
    CCDS27717.1
    UniProtKB/Swiss-Prot
    Q3UP97, Q8C4H6, Q8C5E1, Q91YN1
    Related
    ENSMUSP00000023069.8, ENSMUST00000023069.9
    Conserved Domains (1) summary
    pfam13289
    Location:142 → 247
    SIR2_2; SIR2-like domain

RNA

  1. NR_166139.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL772308

  2. NR_166140.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL772308

  3. NR_166141.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL772308

  4. NR_166142.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL772308

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    84921263..85001781
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177067.3: Suppressed sequence

    Description
    NM_177067.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91YN1.1 GenPept UniProtKB/Swiss-Prot:Q91YN1

Gene LinkOut

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