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NPIPB2 nuclear pore complex interacting protein family member B2 [ Homo sapiens (human) ]

Gene ID: 729978, updated on 3-Apr-2024

Summary

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Official Symbol
NPIPB2provided by HGNC
Official Full Name
nuclear pore complex interacting protein family member B2provided by HGNC
Primary source
HGNC:HGNC:37451
See related
Ensembl:ENSG00000234719 AllianceGenome:HGNC:37451
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See NPIPB2 in Genome Data Viewer
Location:
16p13.13
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (11927263..11976643, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (11963311..12012756, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (12021120..12070500, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr16:11932294-11932479 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:11944561-11945760 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:11946068-11946601 Neighboring gene ribosomal L1 domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7211 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7212 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:12009257-12010194 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:12011253-12011753 Neighboring gene G1 to S phase transition 1 Neighboring gene cytochrome c oxidase subunit 6C pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7215 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10461 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10462 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:12066613-12067113 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:12069255-12069906 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7216 Neighboring gene TNF receptor superfamily member 17 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10463 Neighboring gene ubiquitin like 5 pseudogene 4 Neighboring gene sorting nexin 29 Neighboring gene Sharpr-MPRA regulatory region 15429 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:12169236-12169786 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10465 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7217 Neighboring gene uncharacterized LOC642696 Neighboring gene ribosomal protein S23 pseudogene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Group X secretory phospholipase A2 can induce arachidonic acid release and eicosanoid production without activation of cytosolic phospholipase A2 alpha. Saiga A, et al. Prostaglandins Other Lipid Mediat, 2005 Jan. PMID 15789617
  2. The sequence and analysis of duplication-rich human chromosome 16. Martin J, et al. Nature, 2004 Dec 23. PMID 15616553
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. sPLA2-X induces potent arachidonic acid release without activation of cytosolic phospholipase A2 alpha.
    Title: Group X secretory phospholipase A2 can induce arachidonic acid release and eicosanoid production without activation of cytosolic phospholipase A2 alpha.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative nuclear pore complex-interacting protein family member B2
Names
putative NPIP-like protein LOC729978

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355514.1 → NP_001342443.1  putative nuclear pore complex-interacting protein family member B2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC007216
    Conserved Domains (1) summary
    pfam06409
    Location:1 → 125
    NPIP; Nuclear pore complex interacting protein (NPIP)

  2. NM_001395852.1 → NP_001382781.1  putative nuclear pore complex-interacting protein family member B2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC007216
    Conserved Domains (1) summary
    pfam06409
    Location:1 → 125
    NPIP; Nuclear pore complex interacting protein (NPIP)

  3. NM_001395853.1 → NP_001382782.1  putative nuclear pore complex-interacting protein family member B2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC007216
    Conserved Domains (1) summary
    pfam06409
    Location:1 → 125
    NPIP; Nuclear pore complex interacting protein (NPIP)

  4. NM_001395854.1 → NP_001382783.1  putative nuclear pore complex-interacting protein family member B2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC007216
    Consensus CDS
    CCDS92109.1
    UniProtKB/TrEMBL
    A0A5F9ZI19
    Related
    ENSP00000500799.1, ENST00000673243.1

  5. NM_001395855.1 → NP_001382784.1  putative nuclear pore complex-interacting protein family member B2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC007216
    Consensus CDS
    CCDS92109.1
    UniProtKB/TrEMBL
    A0A5F9ZI19

  6. NM_001396485.1 → NP_001383414.1  putative nuclear pore complex-interacting protein family member B2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC007216
    Consensus CDS
    CCDS92110.1
    UniProtKB/Swiss-Prot
    A0A0A6YYH2, A6NJ64, J3KPX4
    UniProtKB/TrEMBL
    F8VY45
    Related
    ENSP00000382101.4, ENST00000399147.8
    Conserved Domains (2) summary
    PTZ00449
    Location:290 → 389
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam06409
    Location:27 → 299
    NPIP; Nuclear pore complex interacting protein (NPIP)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    11927263..11976643 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434580.1 → XP_047290536.1  putative nuclear pore complex-interacting protein family member B2 isoform X2

  2. XM_047434579.1 → XP_047290535.1  putative nuclear pore complex-interacting protein family member B2 isoform X1

  3. XM_047434581.1 → XP_047290537.1  putative nuclear pore complex-interacting protein family member B2 isoform X5

  4. XM_024450431.1 → XP_024306199.1  putative nuclear pore complex-interacting protein family member B2 isoform X4

    Conserved Domains (1) summary
    pfam06409
    Location:1 → 125
    NPIP; Nuclear pore complex interacting protein (NPIP)

  5. XM_024450429.2 → XP_024306197.1  putative nuclear pore complex-interacting protein family member B2 isoform X3

    Conserved Domains (1) summary
    pfam06409
    Location:1 → 101
    NPIP; Nuclear pore complex interacting protein (NPIP)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    11963311..12012756 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_012736.2: Suppressed sequence

    Description
    NG_012736.2: This RefSeq was removed because it is now thought that this locus encodes a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NJ64.4 GenPept UniProtKB/Swiss-Prot:A6NJ64

Gene LinkOut

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Molecular Biology Databases
Research Materials