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MORN2 MORN repeat containing 2 [ Homo sapiens (human) ]

Gene ID: 729967, updated on 2-Nov-2024

Summary

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Official Symbol
MORN2provided by HGNC
Official Full Name
MORN repeat containing 2provided by HGNC
Primary source
HGNC:HGNC:30166
See related
Ensembl:ENSG00000188010 AllianceGenome:HGNC:30166
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MOPT; BLOCK27
Summary
Predicted to be involved in cell differentiation and spermatogenesis. Predicted to be located in acrosomal vesicle and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis (RPKM 66.4), kidney (RPKM 22.6) and 16 other tissues See more
Orthologs
mouse all
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Genomic context

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See MORN2 in Genome Data Viewer
Location:
2p22.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (38875976..38882709)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (38884462..38891196)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (39103117..39109850)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene DExH-box helicase 57 Neighboring gene argininosuccinate synthetase 1 pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 4728 Neighboring gene uncharacterized LOC105374470 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15611 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:39102285-39103268 Neighboring gene RNA, U6 small nuclear 851, pseudogene Neighboring gene Rho guanine nucleotide exchange factor 33 Neighboring gene uncharacterized LOC105374471 Neighboring gene RNA, 7SL, cytoplasmic 96, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Screening in planarians identifies MORN2 as a key component in LC3-associated phagocytosis and resistance to bacterial infection. Abnave P, et al. Cell Host Microbe, 2014 Sep 10. PMID 25211076
  2. Identification and characterization of a novel mouse and human MOPT gene containing MORN-motif protein in testis. Choi YJ, et al. Theriogenology, 2010 Feb. PMID 19913896
  3. Characterization of MORN2 stability and regulatory function in LC3-associated phagocytosis in macrophages. Morita M, et al. Biol Open, 2020 Jun 23. PMID 32414768, Free PMC Article
  4. Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra. Yu LR, et al. J Proteome Res, 2007 Nov. PMID 17924679
  5. Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. Landers JE, et al. Proc Natl Acad Sci U S A, 2009 Jun 2. PMID 19451621, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MOPT is associated with dynamic regulation of acrosome biogenesis during late spermiogenesis.
    Title: Identification and characterization of a novel mouse and human MOPT gene containing MORN-motif protein in testis.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog
Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC111382, MGC126130, MGC126131, MGC126132

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
MORN repeat-containing protein 2
Names
MORN motif protein in testis
protein containing single MORN motif in testis

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145450.3 → NP_001138922.2  MORN repeat-containing protein 2

    Status: VALIDATED

    Source sequence(s)
    AC018693, KF510812
    Consensus CDS
    CCDS46262.2
    UniProtKB/TrEMBL
    A0A2R8YE86
    Related
    ENSP00000494143.2, ENST00000644631.4
    Conserved Domains (1) summary
    COG4642
    Location:51 → 139
    COG4642; Uncharacterized conserved protein [Function unknown]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    38875976..38882709
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    38884462..38891196
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_194270.1: Suppressed sequence

    Description
    NM_194270.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q502X0.2 GenPept UniProtKB/Swiss-Prot:Q502X0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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