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ZNF878 zinc finger protein 878 [ Homo sapiens (human) ]

Gene ID: 729747, updated on 28-Oct-2024

Summary

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Official Symbol
ZNF878provided by HGNC
Official Full Name
zinc finger protein 878provided by HGNC
Primary source
HGNC:HGNC:37246
See related
Ensembl:ENSG00000257446 AllianceGenome:HGNC:37246
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Oct 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
all
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Genomic context

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See ZNF878 in Genome Data Viewer
Location:
19p13.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (12043602..12052961, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (12171809..12181178, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (12154620..12163776, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ZNF433 and ZNF878 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14042 Neighboring gene RNA, 5S ribosomal pseudogene 464 Neighboring gene zinc finger protein 433 Neighboring gene RNA, 5S ribosomal pseudogene 465 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10137 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10138 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10139 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10140 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:12163610-12164115 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14043 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10141 Neighboring gene zinc finger protein 844 Neighboring gene RNA, 5S ribosomal pseudogene 466 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10142 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10143 Neighboring gene zinc finger family member 788, pseudogene Neighboring gene ribosomal L24 domain containing 1 pseudogene 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. Chang YJ, et al. Int J Mol Sci, 2023 Jun 6. PMID 37372979, Free PMC Article
  2. Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets. Mihalič F, et al. Nat Commun, 2023 Sep 13. PMID 37704626, Free PMC Article
  3. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 878

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080404.3 → NP_001073873.2  zinc finger protein 878

    See identical proteins and their annotated locations for NP_001073873.2

    Status: VALIDATED

    Source sequence(s)
    AC022415, BQ222464, DA007842
    Consensus CDS
    CCDS45984.2
    UniProtKB/Swiss-Prot
    C9JN71
    Related
    ENSP00000447931.1, ENST00000547628.2
    Conserved Domains (6) summary
    smart00349
    Location:4 → 46
    KRAB; krueppel associated box
    COG5048
    Location:122 → 521
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:397 → 417
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    pfam13465
    Location:353 → 378
    zf-H2C2_2; Zinc-finger double domain
    cl19237
    Location:170 → 210
    DUF45; Protein of unknown function DUF45

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    12043602..12052961 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439308.1 → XP_047295264.1  zinc finger protein 878 isoform X3

  2. XM_017027196.2 → XP_016882685.1  zinc finger protein 878 isoform X2

  3. XM_017027195.2 → XP_016882684.1  zinc finger protein 878 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    12171809..12181178 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321927.1 → XP_054177902.1  zinc finger protein 878 isoform X3

  2. XM_054321926.1 → XP_054177901.1  zinc finger protein 878 isoform X2

  3. XM_054321925.1 → XP_054177900.1  zinc finger protein 878 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
C9JN71.2 GenPept UniProtKB/Swiss-Prot:C9JN71

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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