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TYK2 tyrosine kinase 2 [ Homo sapiens (human) ]

Gene ID: 7297, updated on 11-Apr-2024

Summary

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Official Symbol
TYK2provided by HGNC
Official Full Name
tyrosine kinase 2provided by HGNC
Primary source
HGNC:HGNC:12440
See related
Ensembl:ENSG00000105397 MIM:176941; AllianceGenome:HGNC:12440
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JTK1; IMD35
Summary
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with Immunodeficiency 35. [provided by RefSeq, Sep 2020]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression
Ubiquitous expression in spleen (RPKM 21.6), bone marrow (RPKM 20.9) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See TYK2 in Genome Data Viewer
Location:
19p13.2
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (10350533..10380572, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (10476657..10506988, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (10461209..10491248, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr19:10427579-10427770 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:10430834-10431047 Neighboring gene ribonucleoprotein, PTB binding 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10442682-10443598 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10443599-10444515 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10445230-10445848 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10448906-10449654 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13959 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10450403-10451150 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13960 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10451151-10451898 Neighboring gene intercellular adhesion molecule 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10463923-10464686 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10474734-10475234 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:10491214-10491877 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13962 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13963 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10499431-10499931 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10066 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13965 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10067 Neighboring gene cell division cycle 37, HSP90 cochaperone Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13966 Neighboring gene microRNA 1181 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10068 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13967 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10527911-10528462 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10528463-10529013 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10530007-10530886 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10069 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13968 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10070 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13969 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10071 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10072 Neighboring gene phosphodiesterase 4A Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10542553-10543236 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10543237-10543919 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10546465-10546964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13970 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13971 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10075 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10076 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10572008-10572732

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. TYK2 single-nucleotide variants associated with the severity of COVID-19 disease. Zabihi Rizi F, et al. Arch Virol, 2023 Mar 23. PMID 36959416, Free PMC Article
  2. Tyk2 Targeting in Immune-Mediated Inflammatory Diseases. Rusiñol L, et al. Int J Mol Sci, 2023 Feb 8. PMID 36834806, Free PMC Article
  3. Clinical Implications of Targeting the JAK-STAT Pathway in Psoriatic Disease: Emphasis on the TYK2 Pathway. Loo WJ, et al. J Cutan Med Surg, 2023 Jan-Feb. PMID 36519621
  4. The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α. Chandra V, et al. Nat Commun, 2022 Oct 26. PMID 36289205, Free PMC Article
  5. Association of germline TYK2 variation with lung cancer and non-Hodgkin lymphoma risk. Yarmolinsky J, et al. Int J Cancer, 2022 Dec 15. PMID 35747941, Free PMC Article

See all (238) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Community analysis of large-scale molecular dynamics simulations elucidated dynamics-driven allostery in tyrosine kinase 2.
    Title: Community analysis of large-scale molecular dynamics simulations elucidated dynamics-driven allostery in tyrosine kinase 2.
  2. Direct and biologically significant interactions of human herpesvirus 8 interferon regulatory factor 1 with STAT3 and Janus kinase TYK2.
    Title: Direct and biologically significant interactions of human herpesvirus 8 interferon regulatory factor 1 with STAT3 and Janus kinase TYK2.
  3. Tick-borne flavivirus NS5 antagonizes interferon signaling by inhibiting the catalytic activity of TYK2.
    Title: Tick-borne flavivirus NS5 antagonizes interferon signaling by inhibiting the catalytic activity of TYK2.
  4. The positive feedback loop of MAD2L1/TYK2/STAT3 induces progression in B-cell acute lymphoblastic leukaemia.
    Title: The positive feedback loop of MAD2L1/TYK2/STAT3 induces progression in B-cell acute lymphoblastic leukaemia.
  5. TYK2 single-nucleotide variants associated with the severity of COVID-19 disease.
    Title: TYK2 single-nucleotide variants associated with the severity of COVID-19 disease.
  6. Tyk2 Targeting in Immune-Mediated Inflammatory Diseases.
    Title: Tyk2 Targeting in Immune-Mediated Inflammatory Diseases.
  7. Polymorphisms in ACE1, TMPRSS2, IFIH1, IFNAR2, and TYK2 Genes Are Associated with Worse Clinical Outcomes in COVID-19.
    Title: Polymorphisms in ACE1, TMPRSS2, IFIH1, IFNAR2, and TYK2 Genes Are Associated with Worse Clinical Outcomes in COVID-19.
  8. Clinical Implications of Targeting the JAK-STAT Pathway in Psoriatic Disease: Emphasis on the TYK2 Pathway.
    Title: Clinical Implications of Targeting the JAK-STAT Pathway in Psoriatic Disease: Emphasis on the TYK2 Pathway.
  9. The type 1 diabetes gene TYK2 regulates beta-cell development and its responses to interferon-alpha.
    Title: The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α.
  10. Association of germline TYK2 variation with lung cancer and non-Hodgkin lymphoma risk.
    Title: Association of germline TYK2 variation with lung cancer and non-Hodgkin lymphoma risk.
Submit: New GeneRIF Correction See all GeneRIFs (111)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Immunodeficiency 35
MedGen: C1969086 OMIM: 611521 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.
EBI GWAS Catalog
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
EBI GWAS Catalog
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
EBI GWAS Catalog
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
EBI GWAS Catalog
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog
The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables growth hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables growth hormone receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables non-membrane spanning protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine kinase activity EXP
Inferred from Experiment
more info
 PubMed 
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine kinase activity TAS
Traceable Author Statement
more info
  
enables type 1 angiotensin receptor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway via JAK-STAT IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell surface receptor signaling pathway via JAK-STAT TAS
Traceable Author Statement
more info
 PubMed 
involved_in cellular response to virus NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
  
involved_in growth hormone receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in interleukin-12-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of NK T cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of NK T cell proliferation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of T cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of T-helper 17 type immune response NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of interleukin-17 production NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of natural killer cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein localization to nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of receptor signaling pathway via JAK-STAT IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of type II interferon production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in type I interferon-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in type I interferon-mediated signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in type I interferon-mediated signaling pathway TAS
Traceable Author Statement
more info
  
involved_in type II interferon-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in type III interferon-mediated signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasmic side of plasma membrane IC
Inferred by Curator
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
is_active_in extrinsic component of plasma membrane TAS
Traceable Author Statement
more info
 PubMed 
part_of interleukin-12 receptor complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of interleukin-23 receptor complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
non-receptor tyrosine-protein kinase TYK2
NP_001372126.1
NP_001372127.1
NP_001372128.1
NP_001372129.1
NP_001372130.1
NP_001372131.1
NP_001372132.1
NP_001372133.1
NP_001372134.1
NP_001372135.1
NP_001372136.1
NP_001393390.1
NP_003322.3
XP_011526548.1
XP_011526549.1
XP_011526551.1
XP_047295260.1
XP_047295261.1
XP_047295262.1
XP_047295263.1
XP_054177893.1
XP_054177894.1
XP_054177895.1
XP_054177896.1
XP_054177897.1
XP_054177898.1
XP_054177899.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007872.1 RefSeqGene

    Range
    5001..35045
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_121

mRNA and Protein(s)

  1. NM_001385197.1 → NP_001372126.1  non-receptor tyrosine-protein kinase TYK2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC011557
    Consensus CDS
    CCDS92513.1
    UniProtKB/TrEMBL
    A0A8E7DA23, H0YE24
    Related
    ENSP00000434831.2, ENST00000525976.6
    Conserved Domains (6) summary
    cd05076
    Location:589 → 867
    PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    pfam17887
    Location:285 → 432
    Jak1_Phl; Jak1 pleckstrin homology-like domain
    pfam18377
    Location:143 → 266
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:28 → 125
    FERM_F1; FERM F1 ubiquitin-like domain
    cl15255
    Location:437 → 534
    SH2; Src homology 2 (SH2) domain
    cl21453
    Location:892 → 1137
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001385198.1 → NP_001372127.1  non-receptor tyrosine-protein kinase TYK2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC011557
    UniProtKB/TrEMBL
    A0A8V8TPJ0
    Conserved Domains (6) summary
    cd05076
    Location:589 → 867
    PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    pfam17887
    Location:285 → 432
    Jak1_Phl; Jak1 pleckstrin homology-like domain
    pfam18377
    Location:143 → 266
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:28 → 125
    FERM_F1; FERM F1 ubiquitin-like domain
    cl15255
    Location:437 → 534
    SH2; Src homology 2 (SH2) domain
    cl21453
    Location:892 → 1124
    PKc_like; Protein Kinases, catalytic domain

  3. NM_001385199.1 → NP_001372128.1  non-receptor tyrosine-protein kinase TYK2 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC011557
    UniProtKB/TrEMBL
    A0A8E7DA23
    Conserved Domains (6) summary
    cd05080
    Location:830 → 1112
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    pfam17887
    Location:285 → 432
    Jak1_Phl; Jak1 pleckstrin homology-like domain
    pfam18377
    Location:143 → 266
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:28 → 125
    FERM_F1; FERM F1 ubiquitin-like domain
    cl15255
    Location:437 → 534
    SH2; Src homology 2 (SH2) domain
    cl21453
    Location:586 → 805
    PKc_like; Protein Kinases, catalytic domain

  4. NM_001385200.1 → NP_001372129.1  non-receptor tyrosine-protein kinase TYK2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC011557
    UniProtKB/TrEMBL
    A0A8E7DA23
    Conserved Domains (6) summary
    cd05076
    Location:589 → 866
    PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    cd05080
    Location:891 → 1173
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    pfam17887
    Location:285 → 432
    Jak1_Phl; Jak1 pleckstrin homology-like domain
    pfam18377
    Location:143 → 266
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:28 → 125
    FERM_F1; FERM F1 ubiquitin-like domain
    cl15255
    Location:437 → 534
    SH2; Src homology 2 (SH2) domain

  5. NM_001385201.1 → NP_001372130.1  non-receptor tyrosine-protein kinase TYK2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC011557
    UniProtKB/TrEMBL
    A0A8E7DA23
    Conserved Domains (6) summary
    cd05076
    Location:523 → 801
    PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    cd05080
    Location:826 → 1108
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    pfam18377
    Location:143 → 266
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:28 → 125
    FERM_F1; FERM F1 ubiquitin-like domain
    cl15255
    Location:371 → 468
    SH2; Src homology 2 (SH2) domain
    cl17171
    Location:270 → 371
    PH-like; Pleckstrin homology-like domain

  6. NM_001385202.1 → NP_001372131.1  non-receptor tyrosine-protein kinase TYK2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC011557
    UniProtKB/TrEMBL
    A0A8E7DA23
    Conserved Domains (6) summary
    cd05080
    Location:864 → 1146
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    pfam17887
    Location:285 → 432
    Jak1_Phl; Jak1 pleckstrin homology-like domain
    pfam18377
    Location:143 → 266
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:28 → 125
    FERM_F1; FERM F1 ubiquitin-like domain
    cl15255
    Location:437 → 534
    SH2; Src homology 2 (SH2) domain
    cl21453
    Location:589 → 839
    PKc_like; Protein Kinases, catalytic domain

  7. NM_001385203.1 → NP_001372132.1  non-receptor tyrosine-protein kinase TYK2 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC011557
    UniProtKB/TrEMBL
    A0A8E7DA23
    Conserved Domains (6) summary
    cd05076
    Location:589 → 867
    PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    cd05080
    Location:919 → 1201
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    pfam17887
    Location:285 → 432
    Jak1_Phl; Jak1 pleckstrin homology-like domain
    pfam18377
    Location:143 → 266
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:28 → 125
    FERM_F1; FERM F1 ubiquitin-like domain
    cl15255
    Location:437 → 534
    SH2; Src homology 2 (SH2) domain

  8. NM_001385204.1 → NP_001372133.1  non-receptor tyrosine-protein kinase TYK2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC011557
    UniProtKB/TrEMBL
    A0A8E7DA23
    Related
    ENST00000529370.6
    Conserved Domains (6) summary
    cd05080
    Location:962 → 1244
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    pfam17887
    Location:285 → 432
    Jak1_Phl; Jak1 pleckstrin homology-like domain
    pfam18377
    Location:143 → 266
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:28 → 125
    FERM_F1; FERM F1 ubiquitin-like domain
    cl15255
    Location:437 → 534
    SH2; Src homology 2 (SH2) domain
    cl21453
    Location:589 → 937
    PKc_like; Protein Kinases, catalytic domain

  9. NM_001385205.1 → NP_001372134.1  non-receptor tyrosine-protein kinase TYK2 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC011557
    UniProtKB/TrEMBL
    A0A8E7DA23
    Conserved Domains (6) summary
    cd05076
    Location:559 → 837
    PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    cd05080
    Location:862 → 1144
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    pfam17887
    Location:255 → 402
    Jak1_Phl; Jak1 pleckstrin homology-like domain
    pfam18377
    Location:143 → 236
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:28 → 125
    FERM_F1; FERM F1 ubiquitin-like domain
    cl15255
    Location:407 → 504
    SH2; Src homology 2 (SH2) domain

  10. NM_001385206.1 → NP_001372135.1  non-receptor tyrosine-protein kinase TYK2 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC011557
    UniProtKB/TrEMBL
    A0A8E7DA23
    Conserved Domains (6) summary
    cd05076
    Location:547 → 825
    PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    cd05080
    Location:850 → 1132
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    pfam17887
    Location:285 → 432
    Jak1_Phl; Jak1 pleckstrin homology-like domain
    pfam18377
    Location:143 → 266
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:28 → 125
    FERM_F1; FERM F1 ubiquitin-like domain
    cl15255
    Location:437 → 490
    SH2; Src homology 2 (SH2) domain

  11. NM_001385207.1 → NP_001372136.1  non-receptor tyrosine-protein kinase TYK2 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC011557
    UniProtKB/TrEMBL
    A0A8E7DA23
    Conserved Domains (6) summary
    cd05080
    Location:886 → 1168
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    pfam17887
    Location:285 → 432
    Jak1_Phl; Jak1 pleckstrin homology-like domain
    pfam18377
    Location:143 → 266
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:28 → 125
    FERM_F1; FERM F1 ubiquitin-like domain
    cl15255
    Location:437 → 534
    SH2; Src homology 2 (SH2) domain
    cl21453
    Location:584 → 861
    PKc_like; Protein Kinases, catalytic domain

  12. NM_001406461.1 → NP_001393390.1  non-receptor tyrosine-protein kinase TYK2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC011557
    Consensus CDS
    CCDS12236.1
    UniProtKB/Swiss-Prot
    P29597, Q6QB10, Q96CH0
    Related
    ENSP00000436175.2, ENST00000531836.6

  13. NM_003331.5 → NP_003322.3  non-receptor tyrosine-protein kinase TYK2 isoform 2

    See identical proteins and their annotated locations for NP_003322.3

    Status: REVIEWED

    Source sequence(s)
    AK308360, BC014243, DA864169
    Consensus CDS
    CCDS12236.1
    UniProtKB/Swiss-Prot
    P29597, Q6QB10, Q96CH0
    UniProtKB/TrEMBL
    A0A8E7DA23
    Related
    ENSP00000431885.1, ENST00000525621.6
    Conserved Domains (7) summary
    smart00219
    Location:897 → 1169
    TyrKc; Tyrosine kinase, catalytic domain
    smart00295
    Location:28 → 273
    B41; Band 4.1 homologues
    cd05076
    Location:589 → 867
    PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    cd05080
    Location:892 → 1174
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    pfam07714
    Location:589 → 866
    Pkinase_Tyr; Protein tyrosine kinase
    cl15255
    Location:437 → 534
    SH2; Src homology 2 (SH2) domain
    cl17171
    Location:270 → 437
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    10350533..10380572 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528246.4 → XP_011526548.1  non-receptor tyrosine-protein kinase TYK2 isoform X2

    See identical proteins and their annotated locations for XP_011526548.1

    UniProtKB/TrEMBL
    E9PM19
    Conserved Domains (7) summary
    smart00219
    Location:798 → 1070
    TyrKc; Tyrosine kinase, catalytic domain
    smart00295
    Location:2 → 174
    B41; Band 4.1 homologues
    cd05076
    Location:490 → 768
    PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    cd05080
    Location:793 → 1075
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    pfam07714
    Location:490 → 767
    Pkinase_Tyr; Protein tyrosine kinase
    cl15255
    Location:338 → 435
    SH2; Src homology 2 (SH2) domain
    cl17171
    Location:171 → 338
    PH-like; Pleckstrin homology-like domain

  2. XM_011528247.2 → XP_011526549.1  non-receptor tyrosine-protein kinase TYK2 isoform X2

    See identical proteins and their annotated locations for XP_011526549.1

    UniProtKB/TrEMBL
    E9PM19
    Related
    ENSP00000433203.1, ENST00000524462.5
    Conserved Domains (7) summary
    smart00219
    Location:798 → 1070
    TyrKc; Tyrosine kinase, catalytic domain
    smart00295
    Location:2 → 174
    B41; Band 4.1 homologues
    cd05076
    Location:490 → 768
    PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    cd05080
    Location:793 → 1075
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    pfam07714
    Location:490 → 767
    Pkinase_Tyr; Protein tyrosine kinase
    cl15255
    Location:338 → 435
    SH2; Src homology 2 (SH2) domain
    cl17171
    Location:171 → 338
    PH-like; Pleckstrin homology-like domain

  3. XM_011528249.3 → XP_011526551.1  non-receptor tyrosine-protein kinase TYK2 isoform X4

    Conserved Domains (5) summary
    smart00219
    Location:455 → 727
    TyrKc; Tyrosine kinase, catalytic domain
    cd05076
    Location:147 → 425
    PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    cd05080
    Location:450 → 732
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    pfam07714
    Location:147 → 424
    Pkinase_Tyr; Protein tyrosine kinase
    cl15255
    Location:15 → 92
    SH2; Src homology 2 (SH2) domain

  4. XM_047439304.1 → XP_047295260.1  non-receptor tyrosine-protein kinase TYK2 isoform X1

  5. XM_047439305.1 → XP_047295261.1  non-receptor tyrosine-protein kinase TYK2 isoform X3

    UniProtKB/TrEMBL
    A0A8V8TN50
    Related
    ENSP00000514329.1, ENST00000699358.1

  6. XM_047439306.1 → XP_047295262.1  non-receptor tyrosine-protein kinase TYK2 isoform X5

    UniProtKB/TrEMBL
    H0YCT7
    Related
    ENSP00000432320.2, ENST00000533334.2

  7. XM_047439307.1 → XP_047295263.1  non-receptor tyrosine-protein kinase TYK2 isoform X6

    UniProtKB/TrEMBL
    A0A8V8TPX5
    Related
    ENSP00000514328.1, ENST00000699355.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    10476657..10506988 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321919.1 → XP_054177894.1  non-receptor tyrosine-protein kinase TYK2 isoform X2

  2. XM_054321920.1 → XP_054177895.1  non-receptor tyrosine-protein kinase TYK2 isoform X2

  3. XM_054321922.1 → XP_054177897.1  non-receptor tyrosine-protein kinase TYK2 isoform X4

  4. XM_054321918.1 → XP_054177893.1  non-receptor tyrosine-protein kinase TYK2 isoform X1

  5. XM_054321921.1 → XP_054177896.1  non-receptor tyrosine-protein kinase TYK2 isoform X3

  6. XM_054321923.1 → XP_054177898.1  non-receptor tyrosine-protein kinase TYK2 isoform X5

  7. XM_054321924.1 → XP_054177899.1  non-receptor tyrosine-protein kinase TYK2 isoform X6

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P29597.3 GenPept UniProtKB/Swiss-Prot:P29597

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