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LOC728743 zinc finger domain-containing protein LOC728743 [ Homo sapiens (human) ]

Gene ID: 728743, updated on 5-Mar-2024

Summary

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Gene symbol
LOC728743
Gene description
zinc finger domain-containing protein LOC728743
See related
Ensembl:ENSG00000284691
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in lymph node (RPKM 5.1), spleen (RPKM 4.4) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See LOC728743 in Genome Data Viewer
Location:
7q36.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (150400702..150412470)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (151579025..151590794)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (150097790..150109558)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene REPIN1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26823 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150065484-150066288 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150066289-150067094 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150067095-150067899 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26824 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26825 Neighboring gene replication initiator 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26826 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18778 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26827 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150078931-150079888 Neighboring gene ZNF775 antisense RNA 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150080845-150081800 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150083270-150083842 Neighboring gene zinc finger protein 775 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150083843-150084413 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150085648-150086246 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150096281-150096868 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150096869-150097456 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150097787-150098311 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150098312-150098835 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:150098842-150099517 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150099518-150100192 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150100193-150100867 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18779 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150103235-150103743 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26828 Neighboring gene uncharacterized LOC124901773 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18780 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26829 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26830 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26831 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26832 Neighboring gene long intergenic non-protein coding RNA 996

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. N(6)-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation. Cheng Y, et al. Cancer Cell, 2021 Jul 12. PMID 34048709, Free PMC Article
  2. Human chromosome 7: DNA sequence and biology. Scherer SW, et al. Science, 2003 May 2. PMID 12690205, Free PMC Article
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ12702, FLJ12789

General protein information

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Preferred Names
zinc finger protein LOC728743

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395974.1 → NP_001382903.1  zinc finger protein LOC728743 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC073111
    Consensus CDS
    CCDS94231.1
    UniProtKB/TrEMBL
    B7ZLF3
    Related
    ENSP00000492887.1, ENST00000498682.3
    Conserved Domains (2) summary
    COG5048
    Location:36 → 188
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:70 → 90
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001395975.1 → NP_001382904.1  zinc finger protein LOC728743 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC073111
    Consensus CDS
    CCDS94231.1
    UniProtKB/TrEMBL
    B7ZLF3
    Conserved Domains (2) summary
    COG5048
    Location:36 → 188
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:70 → 90
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001395976.1 → NP_001382905.1  zinc finger protein LOC728743 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC073111
    Consensus CDS
    CCDS94231.1
    UniProtKB/TrEMBL
    B7ZLF3
    Related
    ENSP00000493097.1, ENST00000642087.2
    Conserved Domains (2) summary
    COG5048
    Location:36 → 188
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:70 → 90
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_001395977.1 → NP_001382906.1  zinc finger protein LOC728743 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC073111
    Consensus CDS
    CCDS94230.1
    UniProtKB/TrEMBL
    A0A286YF50
    Related
    ENSP00000493012.1, ENST00000641717.1
    Conserved Domains (2) summary
    PHA00733
    Location:36 → 77
    PHA00733; hypothetical protein
    sd00017
    Location:39 → 56
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. NR_173085.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC073111
    Related
    ENST00000641330.1

  2. NR_173086.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC073111

  3. NR_173087.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC073111

  4. NR_173088.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC073111

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    150400702..150412470
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420792.1 → XP_047276748.1  zinc finger protein LOC728743 isoform X3

    UniProtKB/TrEMBL
    A0A286YF50

  2. XM_047420787.1 → XP_047276743.1  zinc finger protein LOC728743 isoform X1

    UniProtKB/TrEMBL
    B7ZLF3

  3. XM_047420786.1 → XP_047276742.1  zinc finger protein LOC728743 isoform X1

    UniProtKB/TrEMBL
    B7ZLF3

  4. XM_047420785.1 → XP_047276741.1  zinc finger protein LOC728743 isoform X1

    UniProtKB/TrEMBL
    B7ZLF3

  5. XM_047420788.1 → XP_047276744.1  zinc finger protein LOC728743 isoform X1

    UniProtKB/TrEMBL
    B7ZLF3

  6. XM_047420791.1 → XP_047276747.1  zinc finger protein LOC728743 isoform X3

    UniProtKB/TrEMBL
    A0A286YF50

  7. XM_047420789.1 → XP_047276745.1  zinc finger protein LOC728743 isoform X1

    UniProtKB/TrEMBL
    B7ZLF3

  8. XM_047420790.1 → XP_047276746.1  zinc finger protein LOC728743 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    151579025..151590794
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358925.1 → XP_054214900.1  zinc finger protein LOC728743 isoform X3

    UniProtKB/TrEMBL
    A0A286YF50

  2. XM_054358920.1 → XP_054214895.1  zinc finger protein LOC728743 isoform X1

    UniProtKB/TrEMBL
    B7ZLF3

  3. XM_054358919.1 → XP_054214894.1  zinc finger protein LOC728743 isoform X1

    UniProtKB/TrEMBL
    B7ZLF3

  4. XM_054358918.1 → XP_054214893.1  zinc finger protein LOC728743 isoform X1

    UniProtKB/TrEMBL
    B7ZLF3

  5. XM_054358921.1 → XP_054214896.1  zinc finger protein LOC728743 isoform X1

    UniProtKB/TrEMBL
    B7ZLF3

  6. XM_054358924.1 → XP_054214899.1  zinc finger protein LOC728743 isoform X3

    UniProtKB/TrEMBL
    A0A286YF50

  7. XM_054358917.1 → XP_054214892.1  zinc finger protein LOC728743 isoform X1

    UniProtKB/TrEMBL
    B7ZLF3

  8. XM_054358922.1 → XP_054214897.1  zinc finger protein LOC728743 isoform X1

    UniProtKB/TrEMBL
    B7ZLF3

  9. XM_054358923.1 → XP_054214898.1  zinc finger protein LOC728743 isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001080852.1: Suppressed sequence

    Description
    NM_001080852.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

  2. NR_027237.1: Suppressed sequence

    Description
    NR_027237.1: This RefSeq was removed because it is now thought that this gene does encode a protein.
Nucleotide Protein
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