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NPIPB6 nuclear pore complex interacting protein family member B6 [ Homo sapiens (human) ]

Gene ID: 728741, updated on 3-Apr-2024

Summary

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Official Symbol
NPIPB6provided by HGNC
Official Full Name
nuclear pore complex interacting protein family member B6provided by HGNC
Primary source
HGNC:HGNC:37454
See related
Ensembl:ENSG00000198156 AllianceGenome:HGNC:37454
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NPIPB
Summary
Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 11.9), skin (RPKM 4.0) and 22 other tissues See more
Orthologs
all
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Genomic context

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Location:
16p12.1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (28342517..28364780, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (28623033..28645151, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (28353838..28376101, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 35 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28271835-28272335 Neighboring gene Sharpr-MPRA regulatory region 11993 Neighboring gene SH3 domain binding kinase 1 Neighboring gene uncharacterized LOC124903670 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:28303338-28303509 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7307 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28341775-28342274 Neighboring gene MPRA-validated peak2550 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28347523-28348022 Neighboring gene eukaryotic translation initiation factor 3 subunit C like Neighboring gene microRNA 6862-1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:28414989-28415489 Neighboring gene cell division cycle 37 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer. Vichas A, et al. Nat Commun, 2021 Aug 9. PMID 34373451, Free PMC Article
  2. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. Capalbo L, et al. Nat Commun, 2019 Oct 4. PMID 31586073, Free PMC Article
  3. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

General protein information

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Preferred Names
nuclear pore complex-interacting protein family member B6
Names
nuclear pore complex-interacting protein B type

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282524.2 → NP_001269453.1  nuclear pore complex-interacting protein family member B6

    See identical proteins and their annotated locations for NP_001269453.1

    Status: VALIDATED

    Source sequence(s)
    AC138894, AC138904
    Consensus CDS
    CCDS61892.1
    UniProtKB/Swiss-Prot
    E9PJ23
    UniProtKB/TrEMBL
    B2RXF8
    Conserved Domains (2) summary
    pfam06409
    Location:48 → 301
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl17068
    Location:2 → 41
    AFD_class_I; Adenylate forming domain, Class I superfamily

  2. NM_001395275.1 → NP_001382204.1  nuclear pore complex-interacting protein family member B6

    Status: VALIDATED

    Source sequence(s)
    AC138894, AC138904
    Consensus CDS
    CCDS61892.1
    UniProtKB/Swiss-Prot
    E9PJ23
    UniProtKB/TrEMBL
    B2RXF8
    Related
    ENSP00000512020.1, ENST00000695563.1
    Conserved Domains (2) summary
    pfam06409
    Location:48 → 301
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl17068
    Location:2 → 41
    AFD_class_I; Adenylate forming domain, Class I superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    28342517..28364780 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023631.3 → XP_016879120.1  nuclear pore complex-interacting protein family member B6 isoform X3

    UniProtKB/TrEMBL
    O75199
    Conserved Domains (1) summary
    pfam06409
    Location:23 → 222
    NPIP; Nuclear pore complex interacting protein (NPIP)

  2. XM_005255741.5 → XP_005255798.1  nuclear pore complex-interacting protein family member B6 isoform X1

    See identical proteins and their annotated locations for XP_005255798.1

    UniProtKB/TrEMBL
    E9PS57, I3L0I5
    Related
    ENSP00000435924.1, ENST00000533640.5
    Conserved Domains (2) summary
    pfam06409
    Location:23 → 221
    NPIP; Nuclear pore complex interacting protein (NPIP)
    pfam10243
    Location:330 → 387
    MIP-T3; Microtubule-binding protein MIP-T3

  3. XM_011545931.3 → XP_011544233.1  nuclear pore complex-interacting protein family member B6 isoform X2

    UniProtKB/TrEMBL
    I3L0I5
    Conserved Domains (1) summary
    pfam06409
    Location:10 → 270
    NPIP; Nuclear pore complex interacting protein (NPIP)

  4. XM_047434574.1 → XP_047290530.1  nuclear pore complex-interacting protein family member B6 isoform X1

    UniProtKB/TrEMBL
    E9PS57

  5. XM_047434575.1 → XP_047290531.1  nuclear pore complex-interacting protein family member B6 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    28623033..28645151 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047446688.1 → XP_047302644.1  nuclear pore complex-interacting protein family member B6 isoform X9

  2. XM_047446687.1 → XP_047302643.1  nuclear pore complex-interacting protein family member B6 isoform X8

  3. XM_047446686.1 → XP_047302642.1  nuclear pore complex-interacting protein family member B6 isoform X7

  4. XM_047446683.1 → XP_047302639.1  nuclear pore complex-interacting protein family member B6 isoform X5

  5. XM_047446684.1 → XP_047302640.1  nuclear pore complex-interacting protein family member B6 isoform X6

  6. XM_047446690.1 → XP_047302646.1  nuclear pore complex-interacting protein family member B6 isoform X1

  7. XM_047446685.1 → XP_047302641.1  nuclear pore complex-interacting protein family member B6 isoform X6

  8. XM_047446689.1 → XP_047302645.1  nuclear pore complex-interacting protein family member B6 isoform X1

  9. XM_047446694.1 → XP_047302650.1  nuclear pore complex-interacting protein family member B6 isoform X12

  10. XM_047446692.1 → XP_047302648.1  nuclear pore complex-interacting protein family member B6 isoform X3

  11. XM_047446691.1 → XP_047302647.1  nuclear pore complex-interacting protein family member B6 isoform X10

  12. XM_047446695.1 → XP_047302651.1  nuclear pore complex-interacting protein family member B6 isoform X13

  13. XM_047446693.1 → XP_047302649.1  nuclear pore complex-interacting protein family member B6 isoform X11

  14. XM_047446696.1 → XP_047302652.1  nuclear pore complex-interacting protein family member B6 isoform X14

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9PJ23.1 GenPept UniProtKB/Swiss-Prot:E9PJ23

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