TGFB2-AS1 TGFB2 antisense RNA 1 (head to head) [Homo sapiens (human)] - Gene

Summary

Official Symbol: TGFB2-AS1provided by HGNC
Official Full Name: TGFB2 antisense RNA 1 (head to head)provided by HGNC
Primary source: HGNC:HGNC:50628
See related: AllianceGenome:HGNC:50628
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression: Broad expression in lung (RPKM 1.2), prostate (RPKM 1.2) and 22 other tissues See more
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Genomic context

Location:: 1q41

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (218344196..218345678, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (217578960..217580442, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (218517538..218519020, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TGFB2-AS1 inhibits triple-negative breast cancer progression via interaction with SMARCA4 and regulating its targets TGFB2 and SOX2.
Title: TGFB2-AS1 inhibits triple-negative breast cancer progression via interaction with SMARCA4 and regulating its targets TGFB2 and SOX2.
lncRNA TGFbeta2-AS1 promotes ECM production via TGF-beta2 in human trabecular meshwork cells.
Title: lncRNA TGFβ2-AS1 promotes ECM production via TGF-β2 in human trabecular meshwork cells.
The TGFB2-AS1 lncRNA Regulates TGF-beta Signaling by Modulating Corepressor Activity.
Title: The TGFB2-AS1 lncRNA Regulates TGF-β Signaling by Modulating Corepressor Activity.
This gene produces a long non-coding RNA (lncRNA), that is positively regulated by the transforming growth factor beta (TGFbeta) signaling pathway. This lncRNA mediates the epigenetic silencing of specific genes that belong to TGFbeta and bone morphogenetic protein (BMP) pathways, by promoting repressive histone marks at their promoters, through interaction with components of the polycomb repressive complex 2 (PRC2).
Title: The TGFB2-AS1 lncRNA Regulates TGF-β Signaling by Modulating Corepressor Activity.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

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General gene information

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NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.