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GOLGA8O golgin A8 family member O [ Homo sapiens (human) ]

Gene ID: 728047, updated on 3-Apr-2024

Summary

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Official Symbol
GOLGA8Oprovided by HGNC
Official Full Name
golgin A8 family member Oprovided by HGNC
Primary source
HGNC:HGNC:44406
See related
Ensembl:ENSG00000206127 AllianceGenome:HGNC:44406
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be involved in Golgi organization. Predicted to be located in Golgi apparatus. Predicted to be active in Golgi cis cisterna; Golgi cisterna membrane; and cis-Golgi network. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thyroid (RPKM 29.8), testis (RPKM 14.9) and 23 other tissues See more
Orthologs
all
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Genomic context

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Location:
15q13.3
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (32441914..32461984, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (30238452..30258301, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (32734115..32747835, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene 15q13.2-13.3 gamma inversion distal recombination region Neighboring gene ULK4 pseudogene 1 Neighboring gene U8 small nucleolar RNA Neighboring gene dynamin 1 pseudogene 32 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:32738857-32739358 Neighboring gene RNA, 7SL, cytoplasmic 539, pseudogene Neighboring gene uncharacterized LOC100289543 Neighboring gene uncharacterized LOC124903456 Neighboring gene uncharacterized LOC105376710 Neighboring gene golgin subfamily A member 6-like protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Golgins in the structure and dynamics of the Golgi apparatus. Barr FA, et al. Curr Opin Cell Biol, 2003 Aug. PMID 12892780
  2. The golgin coiled-coil proteins of the Golgi apparatus. Munro S. Cold Spring Harb Perspect Biol, 2011 Jun 1. PMID 21436057, Free PMC Article
  3. A physical interaction network of dengue virus and human proteins. Khadka S, et al. Mol Cell Proteomics, 2011 Dec. PMID 21911577, Free PMC Article
  4. Analysis of the DNA sequence and duplication history of human chromosome 15. Zody MC, et al. Nature, 2006 Mar 30. PMID 16572171
  5. The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch. Kawashima AT, et al. Mol Cell Biol, 2021 Feb 23. PMID 33397691, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi cis cisterna IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in Golgi cisterna membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cis-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
golgin subfamily A member 8O
Names
Golgin subfamily A member 6-like protein 11
Golgin subfamily A member 8O

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277308.1 → NP_001264237.1  golgin subfamily A member 8O

    See identical proteins and their annotated locations for NP_001264237.1

    Status: VALIDATED

    Source sequence(s)
    AC135983, BQ477899, DB068178
    Consensus CDS
    CCDS59252.1
    UniProtKB/Swiss-Prot
    A6NCC3, A6NHZ1, E7ENU5
    UniProtKB/TrEMBL
    A0A0J9YX86
    Related
    ENSP00000423159.2, ENST00000509311.7
    Conserved Domains (1) summary
    pfam15070
    Location:226 → 622
    GOLGA2L5; Putative golgin subfamily A member 2-like protein 5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    32441914..32461984 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450042.2 → XP_024305810.1  golgin subfamily A member 8O isoform X3

    Conserved Domains (1) summary
    pfam15070
    Location:75 → 471
    GOLGA2L5; Putative golgin subfamily A member 2-like protein 5

  2. XM_011521988.4 → XP_011520290.1  golgin subfamily A member 8O isoform X2

    UniProtKB/TrEMBL
    A0A0J9YX86
    Conserved Domains (1) summary
    pfam15070
    Location:226 → 599
    GOLGA2L5; Putative golgin subfamily A member 2-like protein 5

  3. XM_047433006.1 → XP_047288962.1  golgin subfamily A member 8O isoform X1

  4. XM_011521989.4 → XP_011520291.1  golgin subfamily A member 8O isoform X4

    Conserved Domains (1) summary
    pfam01496
    Location:272 → 362
    V_ATPase_I; V-type ATPase 116kDa subunit family

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_012132920.1 Reference GRCh38.p14 PATCHES

    Range
    1960410..1980238 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331873.1 → XP_054187848.1  golgin subfamily A member 8O isoform X3

  2. XM_054331871.1 → XP_054187846.1  golgin subfamily A member 8O isoform X2

  3. XM_054331870.1 → XP_054187845.1  golgin subfamily A member 8O isoform X1

  4. XM_054331872.1 → XP_054187847.1  golgin subfamily A member 8O isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    30238452..30258301 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054378743.1 → XP_054234718.1  golgin subfamily A member 8O isoform X3

  2. XM_054378742.1 → XP_054234717.1  golgin subfamily A member 8O isoform X2

  3. XM_054378741.1 → XP_054234716.1  golgin subfamily A member 8O isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NCC3.3 GenPept UniProtKB/Swiss-Prot:A6NCC3

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