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FAM156B family with sequence similarity 156 member B [ Homo sapiens (human) ]

Gene ID: 727866, updated on 3-Apr-2024

Summary

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Official Symbol
FAM156Bprovided by HGNC
Official Full Name
family with sequence similarity 156 member Bprovided by HGNC
Primary source
HGNC:HGNC:31962
See related
Ensembl:ENSG00000179304 AllianceGenome:HGNC:31962
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TMEM29B
Summary
Predicted to enable methylated histone binding activity. Located in nuclear envelope. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in skin (RPKM 23.6), placenta (RPKM 20.7) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
Xp11.22
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (52891592..52908560)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (52176499..52193446)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (52920622..52937587)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4A2 pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29644 Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:52895119-52896318 Neighboring gene X antigen family member 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:52949629-52950232 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29646 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29647 Neighboring gene uncharacterized LOC124905190 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29648 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29649 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:52963212-52964184 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:52964185-52965156 Neighboring gene family with sequence similarity 156 member A Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:53018839-53019418

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Methylation of three genes encoded by X chromosome in blood leukocytes and colorectal cancer risk. Tian T, et al. Cancer Med, 2021 Jul. PMID 34145793, Free PMC Article
  2. Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome. Chen YT, et al. Genes Chromosomes Cancer, 2006 Apr. PMID 16382448
  3. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article
  4. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. Simpson JC, et al. EMBO Rep, 2000 Sep. PMID 11256614, Free PMC Article
  5. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Methylation of three genes encoded by X chromosome in blood leukocytes and colorectal cancer risk.
    Title: Methylation of three genes encoded by X chromosome in blood leukocytes and colorectal cancer risk.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ33130, FLJ34279, FLJ38843, DKFZp686H1294

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables methylated histone binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
protein FAM156A/FAM156B
Names
protein FAM156A
transmembrane protein 29
transmembrane protein 29/29B
transmembrane protein 29B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099684.2 → NP_001093154.1  protein FAM156A/FAM156B

    See identical proteins and their annotated locations for NP_001093154.1

    Status: VALIDATED

    Source sequence(s)
    AC234031
    Consensus CDS
    CCDS43957.1
    UniProtKB/Swiss-Prot
    B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
    UniProtKB/TrEMBL
    A0A087WVC8
    Related
    ENSP00000422411.1, ENST00000509613.1
    Conserved Domains (1) summary
    pfam15549
    Location:1 → 170
    PGC7_Stella; PGC7/Stella/Dppa3 domain

  2. NM_001321178.3 → NP_001308107.1  protein FAM156A/FAM156B

    Status: VALIDATED

    Source sequence(s)
    AC234031
    Consensus CDS
    CCDS43957.1
    UniProtKB/Swiss-Prot
    B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
    UniProtKB/TrEMBL
    A0A087WVC8
    Related
    ENSP00000424864.1, ENST00000416841.8
    Conserved Domains (1) summary
    pfam15549
    Location:1 → 170
    PGC7_Stella; PGC7/Stella/Dppa3 domain

  3. NM_001321179.2 → NP_001308108.1  protein FAM156A/FAM156B

    Status: VALIDATED

    Source sequence(s)
    AC234031
    Consensus CDS
    CCDS43957.1
    UniProtKB/Swiss-Prot
    B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
    UniProtKB/TrEMBL
    A0A087WVC8
    Related
    ENSP00000469248.1, ENST00000593751.7
    Conserved Domains (1) summary
    pfam15549
    Location:1 → 170
    PGC7_Stella; PGC7/Stella/Dppa3 domain

  4. NM_001321180.1 → NP_001308109.1  protein FAM156A/FAM156B

    Status: VALIDATED

    Source sequence(s)
    AC234031
    Consensus CDS
    CCDS43957.1
    UniProtKB/Swiss-Prot
    B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
    UniProtKB/TrEMBL
    A0A087WVC8
    Conserved Domains (1) summary
    pfam15549
    Location:1 → 170
    PGC7_Stella; PGC7/Stella/Dppa3 domain

  5. NM_001321181.2 → NP_001308110.1  protein FAM156A/FAM156B

    Status: VALIDATED

    Source sequence(s)
    AC234031
    Consensus CDS
    CCDS43957.1
    UniProtKB/Swiss-Prot
    B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
    UniProtKB/TrEMBL
    A0A087WVC8
    Conserved Domains (1) summary
    pfam15549
    Location:1 → 170
    PGC7_Stella; PGC7/Stella/Dppa3 domain

  6. NM_001321182.2 → NP_001308111.1  protein FAM156A/FAM156B

    Status: VALIDATED

    Source sequence(s)
    AC234031
    Consensus CDS
    CCDS43957.1
    UniProtKB/Swiss-Prot
    B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
    UniProtKB/TrEMBL
    A0A087WVC8
    Related
    ENSP00000483008.1, ENST00000616419.4
    Conserved Domains (1) summary
    pfam15549
    Location:1 → 170
    PGC7_Stella; PGC7/Stella/Dppa3 domain

  7. NM_001321183.1 → NP_001308112.1  protein FAM156A/FAM156B

    Status: VALIDATED

    Source sequence(s)
    AC234031
    Consensus CDS
    CCDS43957.1
    UniProtKB/Swiss-Prot
    B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
    UniProtKB/TrEMBL
    A0A087WVC8
    Conserved Domains (1) summary
    pfam15549
    Location:1 → 170
    PGC7_Stella; PGC7/Stella/Dppa3 domain

  8. NM_001321186.2 → NP_001308115.1  protein FAM156A/FAM156B

    Status: VALIDATED

    Source sequence(s)
    AC234031
    Consensus CDS
    CCDS43957.1
    UniProtKB/Swiss-Prot
    B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
    UniProtKB/TrEMBL
    A0A087WVC8
    Conserved Domains (1) summary
    pfam15549
    Location:1 → 170
    PGC7_Stella; PGC7/Stella/Dppa3 domain

  9. NM_001321187.2 → NP_001308116.1  protein FAM156A/FAM156B

    Status: VALIDATED

    Source sequence(s)
    AC234031
    Consensus CDS
    CCDS43957.1
    UniProtKB/Swiss-Prot
    B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
    UniProtKB/TrEMBL
    A0A087WVC8
    Conserved Domains (1) summary
    pfam15549
    Location:1 → 170
    PGC7_Stella; PGC7/Stella/Dppa3 domain

  10. NM_001321188.1 → NP_001308117.1  protein FAM156A/FAM156B

    Status: VALIDATED

    Source sequence(s)
    AC234031
    Consensus CDS
    CCDS43957.1
    UniProtKB/Swiss-Prot
    B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
    UniProtKB/TrEMBL
    A0A087WVC8
    Conserved Domains (1) summary
    pfam15549
    Location:1 → 170
    PGC7_Stella; PGC7/Stella/Dppa3 domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    52891592..52908560
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442415.1 → XP_047298371.1  protein FAM156A/FAM156B isoform X1

    UniProtKB/Swiss-Prot
    B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49

  2. XM_047442416.1 → XP_047298372.1  protein FAM156A/FAM156B isoform X1

    UniProtKB/Swiss-Prot
    B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49

  3. XM_011530817.2 → XP_011529119.1  protein FAM156A/FAM156B isoform X1

    See identical proteins and their annotated locations for XP_011529119.1

    UniProtKB/Swiss-Prot
    B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
    UniProtKB/TrEMBL
    A0A087WVC8
    Conserved Domains (1) summary
    pfam15549
    Location:1 → 170
    PGC7_Stella; PGC7/Stella/Dppa3 domain

  4. XM_047442417.1 → XP_047298373.1  protein FAM156A/FAM156B isoform X1

    UniProtKB/Swiss-Prot
    B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    52176499..52193446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054327677.1 → XP_054183652.1  protein FAM156A/FAM156B isoform X1

    UniProtKB/Swiss-Prot
    B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49

  2. XM_054327678.1 → XP_054183653.1  protein FAM156A/FAM156B isoform X1

    UniProtKB/Swiss-Prot
    B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49

  3. XM_054327676.1 → XP_054183651.1  protein FAM156A/FAM156B isoform X1

    UniProtKB/Swiss-Prot
    B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49

  4. XM_054327679.1 → XP_054183654.1  protein FAM156A/FAM156B isoform X1

    UniProtKB/Swiss-Prot
    B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NDB6.1 GenPept UniProtKB/Swiss-Prot:Q8NDB6

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